Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404
Otvos, L., Feiner, L., Lang, E., Szendrei, G. I., Goedert, M., Lee, V. M‐Y.·1994·Journal of Neuroscience Research
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- High–Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in VivoEmilie Audouard, Sarah Houben, Caterina Masaracchia, Zehra Yilmaz, Valérie Suain, Michèle Authelet, Robert De Decker, Luc Buée, Alain Boom, Karelle Leroy et al. · 2016 · American Journal Of Pathology
- Rapamycin Ester Analog CCI-779/Temsirolimus Alleviates Tau Pathology and Improves Motor Deficit in Mutant Tau Transgenic MiceChristelle Frédérick, Kunié Ando, Karelle Leroy, Céline Héraud, Valérie Suain, Luc Buée, Jean‐Pierre Brion · 2015 · Journal of Alzheimer s Disease
- Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.R. Shiurba, K. Ishiguro, Miho Takahashi, Kazuki Sato, E. T. Spooner, M. Mercken, Rie Yoshida, T. R. Wheelock, H. Yanagawa, K. Imahori et al. · 1996 · Brain Research
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- Postmortem changes in the phosphorylation state of tau-protein in the rat brainUlrich Gärtner, Carsten Janke, Max Holzer, Eugeen Vanmechelen, Thomas Arendt · 1998 · Neurobiology of Aging
- Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brainsXinwen Zhou, Xu Li, Cecilia Björkdahl, Magnus J.C. Sjögren, Irina I. Alafuzoff, Hilkka S. Soininen, Inge Grundke, Khalid Iqbal, Bengt G. Winblad, Jin-Jing Pei · 2006 · Neurobiology of Disease
- Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's diseaseUte Preuß, Eva‐Maria Mandelkow · 1998 · European Journal of Cell Biology
- The interrelationship between selective tau phosphorylation and microtubule associationHan‐qing Xie, Joel M. Litersky, Judith A. Hartigan, Richard Scott Jope, Gail V.W. Johnson · 1998 · Brain Research
- Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cellsAlain Boom, Michèle Authelet, Robert Dedecker, Christelle Frédérick, Roxane Van Heurck, Valéry Daubie, Karelle Leroy, Roland Pochet, Jean‐Pierre Brion · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Semi-Automated Digital Image Analysis of Pick’s Disease and TDP-43 ProteinopathyDavid John Irwin, Matthew D. Byrne, Corey T. McMillan, Felicia Ilyssa Cooper, Steven Edward Arnold, Edward B. Lee, Vivianna M. Van Deerlin, Sharon Xiangwen Xie, Virginia M.‐Y. Lee, Murray Grossman et al. · 2015 · Journal of Histochemistry & Cytochemistry
- β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic TerminalsHsin‐Yi Wu, Po-Cheng Kuo, Yi-Ting Wang, Hao-Tai Lin, Allyson D. Roe, Bo Y. Wang, Chia‐Li Han, Bradley T. Hyman, Yu‐Ju Chen, Hwan‐Ching Tai · 2018 · Journal of Neuropathology & Experimental Neurology
- Modulation of tau phosphorylation and intracellular localization by cellular stressScott M. Jenkins, Marcus ZINNERMAN, Craig Curtis Garner, Gail V.W. Johnson · 2000 · Biochemical Journal
- Microtubule‐associated protein tau in human prostate cancer cells: Isoforms, phosphorylation, and interactionsSkye Souter, Gloria S. Lee · 2009 · Journal of Cellular Biochemistry
- Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3β activation and caspase 3 cleavageWanjoo Chun, G. S. Waldo, Gail V.W. Johnson · 2007 · Journal of Neurochemistry
- Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalusSunil V. Patel, Edward B. Lee, Sharon Xiangwen Xie, Anica C. Law, Eric M. Jackson, Steven Edward Arnold, Christopher M. Clark, Leslie M. J. Shaw, Michael Sean Grady, John Q. Trojanowski et al. · 2012 · Fluids and Barriers of the CNS
- Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau’s interaction with microtubules in axon-like processesBenedikt Niewidok, Maxim Igaev, Frederik Sündermann, Dennis Janning, Lidia Bakota, Roland Brandt · 2016 · Molecular Biology of the Cell
- Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tanglesJane Lauckner, Peter Frey, Changiz Geula · 2003 · Neurobiology of Aging
- Progressive Reduction of Synaptophysin Message in Single Neurons in Alzheimer DiseaseLinda M. Callahan, William A. Vaules, Paul D. Coleman · 2002 · Journal of Neuropathology & Experimental Neurology
- Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathyHenika Patel, Pablo Martínez, Abigail Perkins, Xavier Taylor, Nur Jury, David L. McKinzie, Cristian A. Lasagna‐Reeves · 2021 · Neurobiology of Aging
- Cellular factors modulating the mechanism of tau protein aggregationSarah N. Fontaine, Jonathan J. Sabbagh, Jeremy D. Baker, Carlos R. Martinez Licha, April L. Darling, Chad A. Dickey · 2015 · Cellular and Molecular Life Sciences
- Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathologyLiu, Shan, Breitbart, Ariel, Sun, Yanjie, Mehta, Pankaj D., Boutajangout, Allal, Scholtzova, Henrieta, Wisniewski, Thomas · 2014 · Journal of Neurochemistry
- Sensitive quantitative assays for tau and phospho-tau in transgenic mouse modelsChristopher M. Acker, Stefanie K. Forest, Ray Zinkowski, Peter Davies, Cristina d’Abramo · 2012 · Neurobiology of Aging
- Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseasesSteven Edward Arnold, Jon B. Toledo, Dina H. Appleby, Sharon Xiangwen Xie, Weixin Wang, Young Baek, David A. Wolk, Edward B. Lee, Bruce L. Miller, Virginia M.‐Y. Lee et al. · 2013 · The Journal of Comparative Neurology
- In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing MiceJosé Morales‐Corraliza, Matthew J. Mazzella, Jason D. Berger, Nicole S. Diaz, Jennifer H. K. Choi, Efrat Levy, Yasuji Matsuoka, Emmanuel Planel, Paul M. Mathews · 2009 · PLoS ONE
- Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation.T. Miyasaka, M. Morishima-kawashima, R. Ravid, P. Heutink, J. V. van Swieten, Kazuo Nagashima, Yasuo Ihara · 2001 · American Journal of Pathology
- Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathologySiddhartha Mondragón‐Rodríguez, R. Mena, Lester I. Binder, Mark A. Smith, George L. Perry, Francisco García‐Sierra · 2007 · Neuropathology and Applied Neurobiology
- HIV-1 Tat contributes to Alzheimer's disease-like pathology in PSAPP mice.Brian N. Giunta, Houyan Hou, Yuyan Zhu, Elona Rrapo, Jun Tian, Takashi Mori, Deborah Commins, Elyse J. Singer, Johnny J. He, Francisco Fernandez et al. · 2009 · PubMed Central
- Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s diseaseVanesa R. Hyde, Chaoming Zhou, J R Muñóz y Fernández, Krishnashis Chatterjee, Pururav Ramakrishna, Amanda Lin, Gregory W. Fisher, Orhan T. Celiker, Jill Caldwell, Omer Bender et al. · 2025 · Cell Reports
- The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron modelDaisuke Tanokashira, Naomi Mamada, Fumiko Yamamoto, Kaori Taniguchi, Akira Tamaoka, Madepalli Krishnappa Lakshmana, Wataru Araki · 2017 · Molecular Brain
- Morphological and Biochemical Correlations of Abnormal Tau Filaments in Progressive Supranuclear PalsyTakahashi, Makio, Weidenheim, Karen M., Dickson, Dennis W., Ksiezak-Reding, Hanna · 2002 · Journal of Neuropathology & Experimental Neurology
- Luminescent Conjugated Oligothiophenes for Sensitive Fluorescent Assignment of Protein Inclusion BodiesTherése Klingstedt, Cristiane Blechschmidt, Anna Nogalska, Stefan Prokop, Bo Häggqvist, Olof Danielsson, W. King Engel, Valerie Askanas, Frank L. Heppner, K. Peter R. Nilsson · 2013 · ChemBioChem
- The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodiesDiane P. Hanger, Graham Gibb, Rohan de Silva, Allal Boutajangout, Jean‐Pierre Brion, Tamás Révész, Andrew J. Lees, Brian H. Anderton · 2002 · FEBS Letters
- Spinal Cord Neurofibrillary Pathology in Alzheimer Disease and Guam Parkinsonism-Dementia ComplexMarie Luise Schmidt, Victoria A. Zhukareva, Daniel P. Perl, Shelley K. Sheridan, Theresa Schuck, Virginia M.‐Y. Lee, John Q. Trojanowski · 2001 · Journal of Neuropathology & Experimental Neurology
- Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degenerationTetsuaki Arai, Kenji Ikeda, Haruhiko Akiyama, Kuniaki Tsuchiya, Shuji Iritani, Koichi Ishiguro, Saburo Yagishita, Tatsuro Oda, Toshinari Odawara, Eizo Iseki · 2003 · Acta Neuropathologica
- Extracellular Vesicles Isolated from Familial Alzheimer’s Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse BrainBrent D. Aulston, Qing Liu, Michael Mante, Jazmin B. Florio, Robert A. Rissman, Shauna H. Yuan · 2019 · Journal of Alzheimer s Disease
- Tau phosphorylation in a mouse model of temporal lobe epilepsy.Alves, Marianna, Kenny, Aidan, de Leo, Gioacchino, Beamer, Edward H., Engel, Tobias · 2019 · Frontiers in Aging Neuroscience
- A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modificationsFriedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan, Helmut E. Meyer, Eva‐Maria Mandelkow, Bettina Warscheid, Eckhard Mandelkow� · 2020 · Journal of Biological Chemistry
- Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tauKevin H. Strang, Marshall S. Goodwin, Cara J. Riffe, Brenda D. Moore, Paramita Chakrabarty, Yona Levites, Todd Eliot Golde, Benoit I. Giasson · 2017 · Acta Neuropathologica Communications
- Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy.Hanna Ksiȩżak-Reding, Elzbieta Tracz, Lixin Yang, Dennis W. Dickson, Martha N. Simon, J.S. Wall · 1996 · Europe PMC (PubMed Central)
- PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosisRavi Shankar Akundi, Lianteng Zhi, Hansruedi Büeler · 2011 · Neurobiology of Disease
- Mutant (R406W) Human Tau Is Hyperphosphorylated and Does Not Efficiently Bind Microtubules in a Neuronal Cortical Cell ModelPavan Krishnamurthy, Gail V.W. Johnson · 2004 · Journal of Biological Chemistry
- Multifunctional Effect of Human Serum Albumin Reduces Alzheimer’s Disease Related Pathologies in the 3xTg Mouse ModelAssaf Ezra, Inna Rabinovich-Nikitin, Polina Rabinovich‐Toidman, Beka Solomon · 2016 · Journal of Alzheimer s Disease
- Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's DiseaseFernando Goñi, Frances Prelli, Yong Ji, Henrieta Scholtzova, Jing Yang, Yanjie Sun, Feng‐Xia Liang, Regina Kascsak, Richard J. Kascsak, Pankaj D Mehta et al. · 2010 · PLoS ONE
- Genetic and neuroanatomic associations in sporadic frontotemporal lobar degenerationCorey T. McMillan, Jon B. Toledo, Brian Avants, Philip A. Cook, Elisabeth McCarty Wood, EunRan R. Suh, David John Irwin, John Powers, Christopher A. Olm, Lauren B. Elman et al. · 2013 · Neurobiology of Aging
- Tau Protein Is Hyperphosphorylated in a Site‐Specific Manner in Apoptotic Neuronal PC12 CellsJianwen Zhang, Gail V. W. Johnson · 2000 · Journal of Neurochemistry
- Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregationNadia El Mammeri, Aurelio James Dregni, Pu Duan, Mei Hong · 2024 · Proceedings of the National Academy of Sciences
- 4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsyOmi Katsuse, Eizo Iseki, Tetsuaki Arai, Haruhiko Akiyama, Takashi Togo, Hirotake Uchikado, Masanori Kato, Rohan de Silva, Andrew John Lees, Kenji Kosaka · 2003 · Acta Neuropathologica
- Glycogen synthase kinase-3β and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neuronsMorel, M., Authelet, M., Dedecker, R., Brion, J.P. · 2010 · Neuroscience
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- Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models*Xuemei Zhang, Israel Hernández, Damien Rei, Waltraud Mair, Joydev K. Laha, Madison E. Cornwell, Gregory D. Cuny, Li‐Huei Tsai, Judith A. J. Steen, Kenneth S. Kosik · 2013 · Journal of Biological Chemistry
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- Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bison⋆W Härtig · 2001 · Neurobiology of Aging
- Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusionsNicola J. Rutherford, Jada M. Lewis, Amy K. Clippinger, Michael A. Thomas, Jennifer L. Adamson, Pedro E. Cruz, Ashley D. Cannon, Guilian M. Xu, Todd Eliot Golde, Gerry Shaw et al. · 2013 · Brain Research
- Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)Garrett S. Gibbons, Soojung Kim, John L. Robinson, Lakshmi N. Changolkar, David John Irwin, Leslie M. J. Shaw, Virginia M.‐Y. Lee, John Q. Trojanowski · 2019 · Acta Neuropathologica Communications
- Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative PhenotypesMarshall S. Goodwin, Olga Sinyavskaya, Franklin Burg, Veronica O’Neal, Carolina Ceballos‐Diaz, Pedro E. Cruz, Jada M. Lewis, Benoit I. Giasson, Peter Davies, Todd Eliot Golde et al. · 2020 · Molecular Therapy
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- Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer’s disease: implications for axoplasmic transportMarina Morel, Céline Héraud, Charles Nicaise, Valérie Suain, Jean‐Pierre Brion · 2011 · Acta Neuropathologica
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- Staging of Alzheimer's Pathology in Triple Transgenic Mice: A Light and Electron Microscopic AnalysisOh, Kwang-Jin, Perez, Sylvia E., Lagalwar, Sarita, Vana, Laurel, Binder, Lester, Mufson, Elliott J. · 2010 · International Journal of Alzheimer's Disease
- Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25Ko Sato, Seiji Minegishi, Jiro Takano, Florian Plattner, Taro Saito, Akiko Asada, Hiroyuki Kawahara, Nobuhisa Iwata, Takaomi C. Saido, Shin‐ichi Hisanaga · 2011 · Journal of Neurochemistry
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- Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in cultureMaría Teresa Moreno-Flores, Ester Martı́n-Aparicio, María Jesús Martín‐Bermejo, Marta Agudo‐Barriuso, Stephen Brendan McMahon, Jesús Ávila, Javier Díaz‐Nido, Francisco G. Wandosell · 2003 · Journal of Neurochemistry
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- GSK-3 dependent phosphoepitopes recognized by PHF-1 and AT-8 antibodies are present in different tau isoformsHERNANDEZ, F · 2003 · Neurobiology of Aging
- α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathiesFrancisco Javier Padilla-Godínez, Eunice Ruth Vázquez-García, María Isabel Trujillo-Villagrán, Luis Oskar Soto-Rojas, Marcela Palomero‐Rivero, Omar Hernández-González, Francisco Pérez-Eugenio, Omar Collazo-Navarrete, Óscar Arias-Carrión, Magdalena Guerra‐Crespo · 2025 · Frontiers in Neuroscience
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- Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western dietMaud Gratuze, Jacinthe Julien, Françoise Morin, André Marette, Emmanuel Planel · 2017 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
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- Ubiquitin is Associated with Early Truncation of Tau Protein at Aspartic Acid421 during the Maturation of Neurofibrillary Tangles in Alzheimer's DiseaseFrancisco García‐Sierra, José Jaime Jarero-Basulto, Zdena Krištofíková, Emerich Majer, Lester I. Binder, Daniela Řı́pová · 2011 · Brain Pathology
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- Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent DeficitsYoungnam N. Jin, Ping‐Chung Chen, Jennifer A. Watson, Brandon J. Walters, Scott E. Phillips, Karen Green, Robert E. Schmidt, Julie A. Wilson, Gail V.W. Johnson, Erik D. Roberson et al. · 2012 · PLoS ONE
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- c‐jun N‐terminal kinase hyperphosphorylates R406W tau at the PHF‐1 site during mitosisYoshitaka Tatebayashi, Emmanuel Planel, Dehua Chui, Shinji Sato, Tomohiro Miyasaka, Naruhiko Sahara, Miyuki Murayama, Naomi Kikuchi, Katsuji Yoshioka, Ravid Rivka et al. · 2006 · The FASEB Journal
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- Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRIAnne Bertrand, Umer Khan, Dung Minh Hoang, Dmitry S. Novikov, Pavan Krishnamurthy, Hameetha Banu Rajamohamed Sait, Benjamin W. Little, Einar M. Sigurdsson, Youssef Zaim Wadghiri · 2012 · NeuroImage
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- Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of TauopathyAndrew J. Trease, Joseph W. George, Nashanthea J. Roland, Eliezer Z. Lichter, Katy M. Emanuel, Steven Totusek, Howard S. Fox, Kelly L. Stauch · 2022 · Frontiers in Molecular Neuroscience
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