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Production of a standard closed fracture in laboratory animal bone
Abstract
To develop a technique for the production of a standard closed experimental fracture, a new apparatus was designed and tested on 40 male Sprague‐Dawley rats. First, the femur was treated with an intramedullary Steinmann pin. The femoral diaphysis was then fractured by means of a blunt guillotine driven by a dropped weight. Radiographically, this technique resulted in a highly reproducible transverse fracture. There was minimal comminution and minimal angulation of the intramedullary pin. Histologically, there was minimal soft tissue damage. Mechanical testing showed that all fractures healed. Pin removal was accomplished with ease and without disturbance of the healed fracture site. The apparatus is simple to use and inexpensive to build. Through its use, a highly reproducible closed fracture model is established.
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Citations
Cited by
The biology of fracture healing
Marsell, R., & Einhorn, T. A. (2011) · Injury · doi:10.1016/j.injury.2011.03.031 · Cited by 1,824
Self-citationKon, T., Cho, T.-J., Aizawa, T., Yamazaki, M., Nooh, N., Graves, D., Gerstenfeld, L. C., & Einhorn, T. A. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1004 · Cited by 552
Self-citationAngiogenesis in Fracture Repair
Glowacki, J. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00010 · Cited by 386
Prevention of fracture healing in rats by an inhibitor of angiogenesis
Hausman, M. R., Schaffler, M. B., & Majeska, R. J. (2001) · Bone · doi:10.1016/s8756-3282(01)00608-1 · Cited by 384
Fracture healing is accelerated in the absence of the adaptive immune system
Toben, D., Schroeder, I., El Khassawna, T., Mehta, M., Hoffmann, J.-E., Frisch, J.-T., Schell, H., Lienau, J., Serra, A., Radbruch, A., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.185 · Cited by 236
Metadata
- Authors
- Bonnarens, F., & Einhorn, T. A.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 1984-01
- Volume
- 2
- Issue
- 1
- Pages
- 97-101
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W1979242330
- Cited by
- 888
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bonnarens, F., & Einhorn, T. A. (1984). Production of a standard closed fracture in laboratory animal bone. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.1100020115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.