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Cited by 209Nerve Injury and RehabilitationElasticity and Material ModelingNerve injury and regeneration

The DOI matches its Crossref record; 29 of the 32 references it cites were found in a registry or an index.

An in vitro mechanical and histological study of acute stretching on rabbit tibial nerve

Rydevik, Björn L., Kwan, Michael K., Myers, Robert R., Brown, Richard A., Triggs, Kevin J., Woo, Savio L‐Y., Garfin, Steven R.·1990·Journal of Orthopaedic Research®
DOI 10.1002/jor.1100080511
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Abstract

Peripheral nerves are often mechanically stretched in association with trauma to extremities, resulting in varying degrees of impairment of nerve function. However, little is known about the biomechanical properties of peripheral nerves and limits of stretching that the nerve may undergo before structural changes occur. Also, the injury pattern of nerves under stretching is poorly understood. In the present study, fresh rabbit tibial nerves (n = 18) were harvested. Nine nerves were stretched to failure in an INSTRON materials testing machine at a rate of 1 cm/min (strain rate of 0.5%/s). Load-deformation and stress-strain curves were determined. Histological examination by light microscopy of the stretched nerves as well as six normal control nerves and three clamped nonstretched control nerves was performed. The results show that the rabbit tibial nerves have an in situ strain of 11.0 +/- 1.5% and exhibit a nonlinear stress-strain relationship. After 20% strain, the curve becomes linear up to failure. The ultimate strain and tensile strength of the nerves were 38.5 +/- 2.0% and 11.7 +/- 0.7 MPa, respectively. At failure, the load dropped suddenly, but the specimens remained grossly intact. Histological analysis of the stretched nerves showed multiple ruptures of perineurial sheaths when compared to controls.

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Crossref · 10.1002/jor.1100080511

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Citations

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Show all 32 references

Research works printed but not linked: 4

  1. Kwan MK, 1989, Biomechanical and histological assessment of human lumbosacral spinal nerve roots, Trans Orthop Res Soc, 14, 348
  2. Kwan MK, 1989, Analysis of rabbit peripheral nerve: in situ stresses and strains, Biom Symp ASME/AMD, 98, 109
  3. Olsson Y, 1969, Inaccessibility of the endoneurium of mouse sciatic nerve to exogenous proteins, Anat Rec, 63, 722
  4. Yoshimura M, 1989, Experimental studies in the traction injury of peripheral nerves, Neuro Orthopedics, 7, 1

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Metadata

Authors
Rydevik, B. L., Kwan, M. K., Myers, R. R., Brown, R. A., Triggs, K. J., Woo, S. L., & Garfin, S. R.
Affiliations
University of California San Diego (US)
ORCID
Brown, Richard A.
Venue
Journal of Orthopaedic Research®
Publisher
Wiley
Published
1990-09
Volume
8
Issue
5
Pages
694-701
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.1100080511
OpenAlex
W2046660728
Cited by
209
References
32
Citations by year
2026: 1 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 14 · 2018: 8 · 2017: 12 · 2016: 5 · 2015: 13 · 2014: 10 · 2013: 8 · 2012: 7
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5284 d)
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS018715, NS 18715)
Topics
  • Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
nerve stretching, tibial nerve, tensile strength, stress-strain behavior, ultimate strain, nerve injury, rabbits
MeSH terms
Animals, Biomechanical Phenomena, Nerve Fibers, Rabbits, Stress, Mechanical, Tibial Nerve

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