The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Morphological basis for back pain: The demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum
Abstract
The innervation of lumbar facet capsule and ligamentum flavum was investigated using antisera to a general neuronal marker protein gene product (PGP) 9.5 and to peptide markers of sensory nerves (calcitonin generelated peptide [CGRP] and substance P) and autonomic nerves (vasoactive intestinal polypeptide [VIP] and C‐flanking peptide of neuropeptide Y [CPON]). In the facet capsule (n = 14), PGP 9.5 and CGRP‐immunoreactive nerves occurred in 12 and five specimens, respectively, both around blood vessels and as free fibers in the stroma. Free fibers immunoreactive for substance P or VIP were noted in three and five specimens, whereas in nine specimens there were CPON‐immunoreactive nerves located perivascularly. There was no immunoreactivity in the ligamentum flavum. This study provides further evidence that the facet capsule but not the ligamentum flavum has substantial innervation by sensory and autonomic nerve fibers and has a structural basis for pain perception.
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Cites
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302
Cited by
Innervation of "Painful" Lumbar Discs
Coppes, M. H., Marani, E., Thomeer, R. T. W. M., & Groen, G. J. (1997) · Spine · doi:10.1097/00007632-199710150-00005 · Cited by 502
Indahl, A., Kaigle, A. M., Reikerås, O., & Holm, S. H. (1997) · Spine · doi:10.1097/00007632-199712150-00006 · Cited by 310
Ohtori, S., Inoue, G., Ito, T., Koshi, T., Ozawa, T., Doya, H., Saito, T., Moriya, H., & Takahashi, K. (2006) · Spine · doi:10.1097/01.brs.0000215027.87102.7c · Cited by 277
Metadata
- Authors
- Ashton, I. K., Ashton, B. A., Gibson, S. J., Polak, J. M., Jaffray, D. C., & Eisenstein, S. M.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 1992-01
- Volume
- 10
- Issue
- 1
- Pages
- 72-78
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2064907293
- Cited by
- 168
- References
- 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Morphological basis for back pain: The demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum. https://app.cochat.ai/papers/10.1002/jor.1100100109
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- Ashton, I. K., Ashton, B. A., Gibson, S. J., Polak, J. M., Jaffray, D. C., & Eisenstein, S. M. (1992). Morphological basis for back pain: The demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.1100100109
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
