Cited by 389Periodontal Regeneration and TreatmentsTendon Structure and TreatmentOrthopedic Surgery and Rehabilitation

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression

Open access

McCarrel, Taralyn, Fortier, Lisa·2009·Journal of Orthopaedic Research

DOI 10.1002/jor.20853

Open this paper in CoChat — free account Open PDF

Abstract

Platelet‐rich plasma (PRP) has generated substantial interest for tendon and ligament regeneration because of the high concentrations of growth factors in platelet α‐granules. This study compared the temporal release of growth factors from bone marrow aspirate (BMA), PRP, and lyophilized platelet product (PP), and measured their effects on tendon and ligament gene expression. Blood and BMA were collected and processed to yield PRP and plasma. Flexor digitorum superficialis tendon (FDS) and suspensory ligament (SL) explants were cultured in 10% plasma in DMEM (control), BMA, PRP, or PP. TGF‐β1 and PDGF‐BB concentrations were determined at 0, 24, and 96 h of culture using ELISA. Quantitative RT‐PCR for collagen types I and III (COL1A1, COL3A1), cartilage oligomeric matrix protein (COMP), decorin, and matrix metalloproteinases‐3 and 13 (MMP‐3, MMP‐13) was performed. TGF‐β1 and PDGF‐BB concentrations were highest in PRP and PP. Growth factor quantity was unchanged in BMA, increased in PRP, and decreased in PP over 4 days. TGF‐β1 and platelet concentrations were positively correlated. Lyophilized PP and PRP resulted in increased COL1A1:COL3A1 ratio, increased COMP, and decreased MMP‐13 expression. BMA resulted in decreased COMP and increased MMP‐3 and MMP‐13 gene expression. Platelet concentration was positively correlated with COL1A1, ratio of COL1A1:COL3A1, and COMP, and negatively correlated with COL3A1, MMP‐13, and MMP‐3. White blood cell concentration was positively correlated with COL3A1, MMP3, and MMP13, and negatively correlated with a ratio of COL1A1:COL3A1, COMP, and decorin. These findings support further in vivo investigation of PRP and PP for treatment of tendonitis and desmitis. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 1033–1042, 2009

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jor.20853

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Granules of the Human Neutrophilic Polymorphonuclear Leukocyte
Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,554
Autologous platelets as a source of proteins for healing and tissue regeneration
Anitua, E., Andı́a, I., Ardanza, B., Nurden, P., & Nurden, A. T. (2003) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0440 · Cited by 1,496
The Roles of Growth Factors in Tendon and Ligament Healing
Molloy, T. J., Wang, Y., & Murrell, G. A. C. (2003) · Sports Medicine · doi:10.2165/00007256-200333050-00004 · Cited by 948
Treatment of Chronic Elbow Tendinosis with Buffered Platelet-Rich Plasma
Mishra, A. K., & Pavelko, T. (2006) · The American Journal of Sports Medicine · doi:10.1177/0363546506288850 · Cited by 918
Growth factors and wound healing: Biochemical properties of growth factors and their receptors
Bennett, N. T., & Schultz, G. S. (1993) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80797-4 · Cited by 658
Comparison of Surgically Repaired Achilles Tendon Tears Using Platelet-Rich Fibrin Matrices
Sánchez, M., Anitua, E., Azofra, J., Andı́a, I., Padilla, S., & Mujika, I. (2006) · The American Journal of Sports Medicine · doi:10.1177/0363546506294078 · Cited by 653
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture
Anitua, E., Andı́a, I., Sánchez, M., Azofra, J., Zalduendo, M., de la Fuente, M., Nurden, P., & Nurden, A. T. (2004) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2004.08.015 · Cited by 505
Platelet Rich Plasma: Biology and New Technology
Pietrzak, W. S., & Eppley, B. L. (2005) · Journal of Craniofacial Surgery · doi:10.1097/01.scs.0000186454.07097.bf · Cited by 408
Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons
Schnabel, L. V., Mohammed, H. O., Miller, B. J., McDermott, W. G., Jacobson, M. S., Santangelo, K. S., & Fortier, L. A. (2007) · Journal of Orthopaedic Research · doi:10.1002/jor.20278 · Cited by 403
Self-citation

Flagged first, then by citations

Show all 61 references

Research works printed but not linked: 1

10.1046/j.1423-0410.1998.7520115.x · DOI

Sorted by citations

Items 301–388 of 388

Platelet-rich plasma in osteoporotic fractures: A review of literature
Singh, A. K., Ali, S., & Srivastava, R. (2014) · Journal of Orthopedics Traumatology and Rehabilitation · doi:10.4103/0975-7341.165250 · Cited by 2
Magnetic resonance imaging‐guided injection of platelet‐rich plasma for treatment of an insertional core lesion of the deep digital flexor tendon within the foot of a horse
Marcatili, M., Marshall, J. F., & Voute, L. C. (2016) · Equine Veterinary Education · doi:10.1111/eve.12697 · Cited by 2
Current Concepts With Video Illustrations Platelet-Rich Plasma: A Milieu of Bioactive Factors
Boswell, S. G., Cole, B. J., Sundman, E. A., Karas, V., & Fortier, L. A. (2012) · Cited by 2
Self-citation
Combining Platelet Rich Plasma and Concentrated Bone Marrow with a Demineralized Bone Matrix Scaffold Enhances Growth Factor Release Over Time
Brewer, J. M., McCarthy, M. B., Pauzenburger, L., Cote, M. P., & Mazzocca, A. D. (2021) · Muscles Ligaments and Tendons Journal · doi:10.32098/mltj.03.2021.13 · Cited by 2
Efficiency of local injections of platelet-rich plasma in shoulder impingement syndrome
Nesterenko, V. А., Karateev, A. E., Byalik, E. I., Макаров, М. А., Makarov, S. A., Bialik, V., Nurmukhametov, M. R., & Fedotov, I. A. (2019) · Modern Rheumatology Journal · doi:10.14412/1996-7012-2019-4-61-65 · Cited by 2
Use of Biologics for Knee Collateral Ligament Injuries. Can We Heal Them Faster?
Dean, R. S., DePhillipo, N. N., & LaPrade, R. F. (2020) · Operative Techniques in Sports Medicine · doi:10.1016/j.otsm.2020.150760 · Cited by 2
Stem Cells in Veterinary Medicine: A Conceptual Approach
Peroni, J. F., & Boone, L. (2015) · doi:10.1002/9781118846193.ch13 · Cited by 2
Principles of Therapy for Lameness
Koch, D. W., Goodrich, L. R., Smanik, L. E., Steward, S. K. T., Ernst, N. S., Trumble, T. N., Parks, A. H., Haussler, K. K., King, M. R., Ellis, K., et al. (2020) · doi:10.1002/9781119276715.ch8 · Cited by 2
The Effect of Platelet Rich Plasma Frequency On Early Stage Knee Osteoarthritis
Atik, A. (2020) · Ege Tıp Bilimleri Dergisi · doi:10.33713/egetbd.674135 · Cited by 1
Dickkopf-1 is present in equine platelet-rich plasma and correlates to platelet concentration
Boger, B. L., Kinsley, M. A., Yob, C. J., Knott, L. E., & Manfredi, J. M. (2025) · American Journal of Veterinary Research · doi:10.2460/ajvr.24.11.0335 · Cited by 1
Analyzing Disparities in Platelet-Rich Plasma Preinjection Protocols for Musculoskeletal Injuries
Barr, J., Stern, M., Hunter, K., Gentile, P. M., & Clinton, C. (2025) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000001384 · Cited by 1
Role of Platelet-rich Plasma in Foot and Ankle Surgery
Mehta, S. K., Sood, A., & Lin, S. S. (2012) · Techniques in Foot & Ankle Surgery · doi:10.1097/btf.0b013e3182463a3d · Cited by 1
[Progress on treatment of tendinopathy with platelet-enriched plasma].
Zheng, Z., Le, H., Chen, W., Shen, W., & Ouyang, H. (2016) · PubMed Central · doi:10.3785/j.issn.1008-9292.2016.03.11 · Cited by 1
Clinical Orthobiological Approach to Acute Cartilage Injury: Pros and Cons
Nakasa, T., Adachi, N., & Ochi, M. (2017) · Springer eBooks · doi:10.1007/978-3-662-54181-4_40 · Cited by 1
Plasma rico em plaquetas: estudo comparativo entre a dupla centrifugação e o filtro E-PET (Equine Platelet Enhancement Therapy)
da Conceição, M. L., Alvarenga, M. L., de Souza, J. B., de Mattos, L. H. L., Rodrigues, C. A., Watanabe, M. J., Hussni, C. A., & Alves, A. L. G. (2017) · Pesquisa Veterinária Brasileira · doi:10.1590/s0100-736x2017000300003 · Cited by 1
Systematic Review The Role of Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: A Systematic Review With Quantitative Synthesis
Chahal, J., Thiel, G. S. V., Heard, W. M. R., Bach, B. R., Cole, B. J., Nicholson, G. P., Verma, N. N., Whelan, D. B., & Romeo, A. A. (2012) · Cited by 1
PLATELETS: BIOLOGICAL PROPERTIES AND CLINICAL POTENTIAL
Холодкова, О. Л. (2018) · Bulletin of Problems Biology and Medicine · doi:10.29254/2077-4214-2018-2-144-73-78 · Cited by 1
Comparative Histopathological Evaluation of Platelet-Rich Plasma Injection and Autologous Blood Injection to Temporomandibular Joint: A Pilot Experimental Study
Gülşen, U., Şentürk, M. F., Yurttutan, M. E., GÜLŞEN, E. A., Bayram, P., Özdemir, D. T., & Erdemlı, E. (2019) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.91535 · Cited by 1
Will Platelet Rich Plasma Open New Era for Treatment of Rotator Cuff Tear?
Choi, S. W. (2018) · Clinics in Shoulder and Elbow · doi:10.5397/cise.2018.21.1.1 · Cited by 1
Regenerative Medicine
Ricco, S., Boone, L., & Peroni, J. F. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0867-7.00008-9 · Cited by 1
Leukocyte-Rich Platelet-Rich Plasma Application in Post-Traumatic Osteoarthritis with Popliteal Cyst: A Case Report
Song, B., Yeh, P. C., & Jayaram, P. (2020) · Regenerative Medicine · doi:10.2217/rme-2020-0021 · Cited by 1
Platelet-rich Plasma in Patients with Symptomatic Osteoarthritis Knee: An Evidence- and Consensus-based 2023 International Society for Musculoskeletal Ultrasound in Pain Medicine Guidelines
Sharma, K., Das, G., Das, S., Jadon, A., Natarajan, K. B., Moorthi, G., Sardar, K., Gadir, E., Novy, T., Dutta, D., et al. (2023) · Journal on Recent Advances in Pain · doi:10.4103/jmupm.jmupm_3_23 · Cited by 1
Equine bone marrow aspirate and bone marrow aspirate concentrate are enriched with interleukin-1 receptor antagonist protein
Long, S. A., Maleas, G., Belacic, Z. A., Quam, V. G., & Durgam, S. S. (2025) · American Journal of Veterinary Research · doi:10.2460/ajvr.24.12.0380 · Cited by 1
Platelet-rich plasma injections for knee pathologies: a review
Kamat, Y. D., Patel, N. G., Galea, A., Ware, H., & Dowd, G. S. E. (2014) · European Orthopaedics and Traumatology · doi:10.1007/s12570-014-0271-1 · Cited by 1
Clinical Applications for Platelet Rich Plasma Therapy
Honbo, E. S., & Podesta, L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-323-07747-7.00010-1 · Cited by 1
Effects of specific pathogen-free porcine platelet-rich plasma activated by the novel activator ectoine on cell proliferation and biological function
Yao, C., Chi, Y.-W., Kao, T.-T., Liu, Y., Chiou, T.-J., & Lai, Y.-T. (2019) · Biochemical Engineering Journal · doi:10.1016/j.bej.2019.107424 · Cited by 1
The Stryker Regenkit PRP Kit Does Not Concentrate Canine Platelets
Cherno, B., Alvarez, L. X., Lamb, K. E., & Canapp, S. O. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.555909 · Cited by 1
Efectos de dos anticoagulantes sobre el recuento celular y parámetros de activación plaquetaria de plasma rico en plaquetas de equinos
Giraldo, C. E., López, C., & Carmona, J. U. (2015) · Archivos de medicina veterinaria · doi:10.4067/s0301-732x2015000300011 · Cited by 1
Efeito do plasma rico em plaquetas associado ao uso do LASER terapêutico em desmite proximal do ligamento suspensor do boleto
Ramos, P. A. R. (2013) · doi:10.11606/d.10.2013.tde-03092014-160828 · Cited by 1
Reply to comments of Carmona et al. to the article: Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses
Torricelli, P., Filardo, G., Kon, E., & Fini, M. (2011) · International Orthopaedics · doi:10.1007/s00264-011-1312-9 · Cited by 1
Optimising the investigation of interventional treatments in lateral elbow tendinopathy
Evans, J. P. (2019) · Open Research Exeter (University of Exeter) · Cited by 1
Laser Therapy in Veterinary Regenerative Medicine
Alves, J. C. (2025) · doi:10.1002/9781394205356.ch36 · Cited by 1
Platelet-Rich Plasma in the Treatment of Cartilage Defects and Early Osteoarthritis of the Knee
Gobbi, A. W., Karnatzikos, G., & Lad, D. G. (2015) · Springer eBooks · doi:10.1007/978-3-642-36569-0_157
Entwickung eines zellfreien, dreidimensionalen Implantates zur Behandlung von Defekten knorpelartiger Gewebe
Haberstroh, K. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5033
Imaging and Treatment of Chronic Midportion Achilles Tendinopathy
de Vos, R. (2010) · EUR Research Repository (Erasmus University Rotterdam)
Resposta ao uso intra-articular do plasma rico em plaquetas em equinos hígidos: aspectos clínicos, laboratoriais e ultrassonográficos
de Moraes, A. P. L. (2013) · doi:10.11606/d.10.2013.tde-04122013-154151
Glycosaminoglycan Dependent Isolation of Mesenchymal Chondroprogenitor Populations from Human Bone Marrow
O’Sullivan, J. (2013) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/16052
RETRACTED: Quelle place pour les plasma riche en plaquettes (PRP) dans les tendinopathies ?
Nourissat, G., Ornetti, P., Berenbaum, F., Sellam, J., Richette, P., & Chevalier, X. (2014) · Revue du Rhumatisme · doi:10.1016/j.rhum.2014.08.007
Retracted
Quelle place pour les PRP (plasma riche en plaquettes) dans les tendinopathies ?
Nourissat, G., Ornetti, P., Berenbaum, F., Sellam, J., Richette, P., & Chevalier, X. (2015) · Revue du Rhumatisme · doi:10.1016/j.rhum.2014.12.001
Biodegradable gelatin microcarriers in tissue engineering : In vitro studies on cartilage and bone
Pettersson, S. (2009) · DiVA (Linkoping University)
Stiffness of the healing human Achilles tendon
Schepull, T. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
PRP in the Treatment of Cartilage Defects and Early Osteoarthritis of the Knee
Gobbi, A. W., Karnatzikos, G., & Lad, D. G. (2014) · Springer eBooks · doi:10.1007/978-3-642-36801-1_157-1
Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica (Platelet-rich plasma in the treatment of articular chondral defects experimentally induced in horses: clinical, macroscopic, histopathological and histochemical evaluation)
Yamada, A. L. M., Carvalho, A. D. M., Oliveira, P. G. G., Felisbino, S. L., Queiroz, D. L., Watanabe, M. J., & Hussni, C. A. (2012)
Role of Platelets Rich Plasma in Management of Osteoporotic Fractures
Singh, A. K. (2014) · Annual Research & Review in Biology · doi:10.9734/arrb/2014/6130
Platelet Rich Plasma in Foot and Ankle Surgery
Cunningham, C., Sood, A., & Lin, S. S. (2016) · Springer eBooks · doi:10.1007/978-1-4471-7271-0_7
Qualitative comparison between equine bone marrow- and blood-derived autologous conditioned serum
Ionita, C., Troillet, A., Brehm, W., Winter, K., & Ionita, J.-C. (2016) · Pferdeheilkunde Equine Medicine · doi:10.21836/pem20160607
Regenerative and innovative joint medication in the horse – Part 2: Efficacy and adverse effects of joint medication in the horse - A review of the literature - The pathogenesis of osteoarthritis in the horse
Ehrle, A., Fürst, A., & Lischer, C. (2013) · Pferdeheilkunde Equine Medicine · doi:10.21836/pem20130208
Laser Therapy in Veterinary Regenerative Medicine
Canapp, D. A. (2017) · doi:10.1002/9781119220190.ch40
Wachstumsfaktoren unter besonderer Berücksichtigung des muskuloskelettalen Systems
Bachl, N., Lorenz, C. D., & Goldspink, G. (2017) · Springer eBooks · doi:10.1007/978-3-7091-1591-6_8
Correlação entre concentrações plaquetárias e de fator de crescimento TGF-β presente em plasma rico em plaquetas de equinos
Seidel, S. R. T. (2017) · doi:10.11606/d.10.2017.tde-23112017-131614
Obtenção de plasma rico em plaquetas autólogo de coelhos com poucos leucócitos e hemácias
Andrade, M. (2014) · doi:10.14393/ufu.di.2014.392
Intérêt du plasma autologue conditionné dans la cicatrisation des tendons de la coiffe des rotateurs après réparation arthroscopique. Évaluation prospective comparative sur arthro-IRM à 6 mois de recul
Aurégan, J.-C., Klouche, S., Levy, B., Bauer, T., Rousselin, B., Ferrand, M., & Hardy, P. (2019) · Revue de Chirurgie Orthopédique et Traumatologique · doi:10.1016/j.rcot.2019.01.009
Injections Including Platelet-Rich Plasma
Angeline, M. E., Zajac, J. M., Gee, A. O., Dines, J. S., & Altchek, D. W. (2015) · Springer eBooks · doi:10.1007/978-1-4899-7540-9_11
Platelet-Rich Plasma for Degenerative Knee Joints: What is the Evidence?
Sarvesh, B., Sharma, K., Das, G., & Agarwal, A. (2019) · Indian Journal of Pain · doi:10.4103/ijpn.ijpn_57_19
Review of Platelet-Derived Cytokines in Hair Transplantation: Endogenous Release of Platelet Growth Factors in Scalp Incisions
Rinaldi, F. (2014) · International Society of Hair Restoration Surgery · doi:10.33589/24.5.0175
The Role of Orthobiologics in the Management of Tendon and Fascia Injuries in Sports
Gilat, R., Abat, F., Chahla, J. A., Haunschild, E. D., Laver, L., & Cole, B. J. (2020) · Springer eBooks · doi:10.1007/978-3-662-61070-1_45
Autologous Bone Marrow Cell Therapy for the Knee: Are We There Yet?
Kunze, K. N., Piuzzi, N. S., Chahla, J. A., & Muschler, G. F. (2020) · Operative Techniques in Sports Medicine · doi:10.1016/j.otsm.2020.150777
Role of Platelet Rich Plasma in Tendon Healing
Maawad, M. H., Anani, R. A. E., Nasr, M., & Yehia, A. (2021) · European Journal of Molecular & Clinical Medicine
Rol del ligando del factor nuclear kappa Beta (RANKL) en osteoartritis y osteoclastogénesis de equinos fina sangre de carrera. Uso de antiinflamatorios
Negri, L. D., Olguín, L. A. P., & Pavéz, L. (2021) · Revista de Investigaciones Veterinarias del Perú · doi:10.15381/rivep.v32i2.20009
The Failed Rotator Cuff: Diagnosis and Management—New Concepts in Biology of Repair
Muench, L. N., Berthold, D. P., & Mazzocca, A. D. (2021) · Springer eBooks · doi:10.1007/978-3-030-79481-1_4
Plasma rico em plaquetas associado a ácido hialurônico e/ ou quitosana para aplicações em medicina regenerativa
Shimojo, A. A. M. (2015) · doi:10.47749/t/unicamp.2015.949312
31 Biological Augmentation of Rotator Cuff Repair with Platelet-Rich Plasma and Multiple Channeling Rotator cuff repair Platelet-rich plasma Multiple channeling
(2021) · Thieme Medical Publishers eBooks · doi:10.1055/b-0041-179893
References
(2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6069-7.00174-7
FUNCTIONAL OUTCOME OF EARLY STAGES OF OSTEOARTHRITIS KNEE TREATED WITH BONE MARROW ASPIRATE CONCENTRATE AND INTRAARTICULAR STEROID
Naik, K. P., & Shankarlinga, S. (2022) · GLOBAL JOURNAL FOR RESEARCH ANALYSIS · doi:10.36106/gjra/5400637
Regeneration of Partial Anterior Cruciate Ligament Tears Using the Technique of Biologic Augmentation with Bone Marrow Concentrate and Platelet-Rich Plasma Under Arthroscopic Visualization
Dallo, I., & Domínguez, P. B. (2023) · Biologic Orthopedics Journal · doi:10.22374/boj.v3isp2.36
Medicina regenerativa en el tratamiento de dolor crónico. Una revisión integrativa de la literatura
Jaimes, G. W. R., Agón, K. A. O., Cediel, X., Quijano, N. A. R., & Diaz, K. N. C. (2023) · Revista Colombiana de Medicina Física y Rehabilitación · doi:10.28957/rcmfr.374
Tratamentos alternativos para endometrite em fêmeas bovinas leiteiras
Pereira, D. C. (2023) · doi:10.47328/ufvbbt.2023.757
Treatment of osteoarthritis knee with bone marrow aspirate concentrate injection
Saha, S., Das, C., Das, P. P., & Gupta, N. (2024) · IP International Journal of Orthopaedic Rheumatology · doi:10.18231/j.ijor.2023.013
Injections of Anatomical Regions and Diseases: Elbow
Alentorn‐Geli, E., & Haua, J. R. (2024) · Springer eBooks · doi:10.1007/978-3-031-52603-9_23
PRP in Tendinopathy
Abat, F., Aznar, I. D. R., Ibáñez, F., & Raflé, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-52603-9_15
Nonoperative Pharmacological and Biologic Strategies for Osteoarthritis
Montagna, A., Herman, K., & Gobbi, A. W. (2024) · Springer eBooks · doi:10.1007/978-3-030-65430-6_56-1
49 Biologics II: Platelet-Rich Plasma
(2024) · Thieme Medical Publishers eBooks · doi:10.1055/b-0043-200988
Autograft vs Allograft With Bone Marrow Aspirate Concentrate as an Osteotomy Gap Filler in Lateral Column Lengthening for Progressive Collapsing Flatfoot Deformity
Radhakrishnan, R., Koh, D. T. S., Cher, E. W. L., Png, W., & Singh, I. R. (2025) · Foot & Ankle Orthopaedics · doi:10.1177/24730114251342580
Efficacité du plasma riche en plaquettes intra-articulaire comparée au placebo dans l’arthrose du genou : revue systématique et méta-analyse
Auroux, M., Debionne, T., Mainbourg, S., & Chapurlat, R. D. (2025) · Revue du Rhumatisme · doi:10.1016/j.rhum.2025.10.011
Orthobiologics in the Foot and Ankle: An Update on the Current Literature
Cottom, J. M., & Verdoni, T. J. (2025) · Foot & Ankle Specialist · doi:10.1177/19386400251382280
Bone morphogenetic protein-2-independent bone formation by human iPSC-derived megakaryocytes and platelets
Mizuki, N., Mukai, M., Shiga, Y., Takayama, N., Nakamura, S., Kosaka, K., Chen, S. J., Paul, S. K., Arai, T., Tashiro, S., et al. (2025) · Bone · doi:10.1016/j.bone.2025.117703
Musculoskeletal Injection Therapy: Part 2
Sciarretta, F. V. (2025) · Springer eBooks · doi:10.1007/978-3-031-77456-0_10
Additional file 1 of Regenerative therapies for femoral head necrosis in the past two decades: a systematic review and network meta-analysis
Wang, X., Hu, L., Wei, B., Wang, J., Hou, D., & Deng, X. (2024) · Figshare · doi:10.6084/m9.figshare.25067259
Additional file 1 of A safety evaluation of allogeneic freeze-dried platelet-rich plasma or conditioned serum compared to autologous frozen products equivalents in equine healthy joints
Garbin, L. C., Contino, E. K., Olver, C. S., & Frisbie, D. D. (2022) · Figshare · doi:10.6084/m9.figshare.19612275
Comparative post-breeding outcomes in jennies inseminated with cryopreserved semen re-extended in seminal plasma or treated with platelet-rich plasma
Joseph, C., Schwarzman, H., Kaplan, C., Machado, M. V. R., Trevisan, B., & Segabinazzi, L. G. T. M. (2026) · Theriogenology · doi:10.1016/j.theriogenology.2026.117832
Efficacy of Bone Marrow Aspirates in Bone Regeneration Compared to Conventional Bone Grafts- A Systematic Review
Kadic, H., Awan, K. H., Bhandi, S., Licari, F. W., Bramucci, C., Patil, S., Testarelli, L., & Nardo, D. D. (2026) · Odovtos - International Journal of Dental Sciences · doi:10.15517/resqjc21
Platelet‐Rich Plasma Injections for the Treatment of Rotator Cuff Pathology Have Higher Complication Rates of Adhesive Capsulitis than Alternative Injectable Therapies: A Systematic Review and Meta‐analysis of Randomized Controlled Trials
Driscoll, A., Griffin, S., Schreiner, G., Fucaloro, S. P., Krivicich, L. M., & Salzler, M. J. (2026) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1002/arj.70163
Modern Orthobiologic Treatment of Achilles Tendinopathy
Vlasak, A. L., & Metzl, J. A. (2026) · Operative Techniques in Sports Medicine · doi:10.1016/j.otsm.2026.151250
Subchondral bone marrow aspirate concentrate injection improves clinical outcomes and reduces bone marrow lesions in knee osteoarthritis: 12-month retrospective analysis
Ezzi, S. H. A., Ding, H. Q., Wu, S., Malik, M. A., Alshabi, M. M. A., Zhang, W., Cao, X., & Huang, J. (2026) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-026-06814-3
Intra‐Articular Therapies
Rychel, J. K., Fry, L. M., & Markley, A. P. (2026) · doi:10.1002/9781394283231.ch22
Investigation into the Short-Term Effects of Intra-Articular Allogenic PRP in the Equine LPS Model of Joint Inflammation: A Randomised Control Trial
Duggan, M. J. S., Kearney, C., Rincon, B. A., Labberté, M. C., Baltrimaite, M., Gibney, R., & Brama, P. A. J. (2026) · Animals · doi:10.3390/ani16162477
Preparation of Platelet Rich Plasma for Veterinary Applications: Techniques and Protocols
Andreoli, V., Berni, P., Conti, V., Ramoni, R., & Grolli, S. (2026) · Springer eBooks · doi:10.1007/978-3-032-21603-8_2
Medical Therapies for the Treatment of Osteoarthritis in the Horse – 20 years later…
Barton, C. K., & Goodrich, L. R. (2026) · The Veterinary Journal · doi:10.1016/j.tvjl.2026.106935

Authors: McCarrel, T., & Fortier, L.
Affiliations: Cornell University (US)
Corresponding author: Fortier, Lisa
ORCID: McCarrel, Taralyn
Fortier, Lisa
Venue: Journal of Orthopaedic Research
Publisher: Wiley
Published: 2009-01-23
Volume: 27
Issue: 8
Pages: 1033-1042
ISSN: 0736-0266 (ISSN-L)
1554-527X
DOI: 10.1002/jor.20853
OpenAlex: W2016774778
Cited by: 389
References: 61
Citations by year: 2026: 10 · 2025: 20 · 2024: 19 · 2023: 17 · 2022: 19 · 2021: 24 · 2020: 22 · 2019: 27 · 2018: 26 · 2017: 20 · 2016: 23 · 2015: 32 · 2014: 30 · 2013: 27 · 2012: 34
FWCI: 28.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Orthopaedic Research® (publishedVersion)
PubMed (publishedVersion)
Funders: Harry M. Zweig Memorial Fund for Equine Research
Topics: Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Health Sciences › Medicine › Surgery › Orthopedic Surgery and Rehabilitation
Keywords: platelet-rich plasma, bone marrow aspirate, growth factor release, tendon regeneration, ligament regeneration, flexor digitorum superficialis tendon, suspensory ligament, TGF-β1, PDGF-BB, collagen I and III, cartilage oligomeric matrix protein, decorin, matrix metalloproteinases, tendinitis, desmitis, gene expression
MeSH terms: Becaplermin, Animals, Blood Platelets, Bone Marrow, Horses, Ligaments, Platelet-Derived Growth Factor, RNA, Messenger, Tendons, Trehalose, Gene Expression, Matrix Metalloproteinase 3, Proto-Oncogene Proteins c-sis, Collagen Type I, Collagen Type III, Intercellular Signaling Peptides and Proteins, Matrix Metalloproteinase 13, Platelet-Rich Plasma, Transforming Growth Factor beta1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks