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Cited by 14Periodontal Regeneration and TreatmentsTendon Structure and TreatmentKnee injuries and reconstruction techniques

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Biologic response of human anterior cruciate ligamentocytes on collagen-patches to platelet-rich plasma formulations with and without leucocytes

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Krismer, Anna M., Cabra, Romina S., May, Rahel D., Frauchiger, Daniela A., Kohl, Sandro, Ahmad, Sufian S., Gantenbein, Benjamin·2017·Journal of Orthopaedic Research
DOI 10.1002/jor.23599
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Abstract

Due to the poor self‐healing capacities of the anterior cruciate ligament, previous primary repair attempts have failed. To enhance biologic healing, platelet rich plasma and collagen scaffold have shown promise in animal models. Platelet rich plasma (PRP) is already used in several clinical applications although outcomes are quite debated. The purpose of this study was to examine the effects of different PRP formulations during 21 days: With leucocytes and pure PRP on human anterior cruciate ligament‐derived ligamentocytes grown on collagen patches in 3D cell cultures in vitro. Three experimental groups were formed: 2.5% leucocyte rich PRP, 2.5% pure PRP, 20% leucocyte rich PRP, a negative control, and a positive control. Cell proliferation, cell phenotype on mRNA transcript level, and extracellular matrix production (total collagen and glycosaminoglycan content) were evaluated. DNA content and metabolic cell activity increased significantly in all groups on day 21 compared to day 7, except in the negative control. No changes in extracellular matrix production were detected. Different catabolic genes were induced depending on the concentration of leucocyte rich PRP. PRP with and without leucocytes treated anterior cruciate ligamentocytes significantly increased cell proliferation but not extracellular matrix production. However, the specific activation of different catabolic genes was dependent on the relative content of leucocytes. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2733–2739, 2017.

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Metadata

Authors
Krismer, A. M., Cabra, R. S., May, R. D., Frauchiger, D. A., Kohl, S., Ahmad, S. S., & Gantenbein, B.
Affiliations
University of Bern (CH)
Corresponding author
Gantenbein, Benjamin
ORCID
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2017-05-30
Volume
35
Issue
12
Pages
2733-2739
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.23599
OpenAlex
W2613260403
Cited by
14
References
21
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 2
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
  • BORIS (University Library Bern) (submittedVersion)
Funders
Universität Zürich
Topics
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Keywords
anterior cruciate ligament, platelet-rich plasma, collagen scaffolds, 3D cell culture, cell proliferation, extracellular matrix synthesis, catabolic gene expression, ligament healing, ligament repair
MeSH terms
Anterior Cruciate Ligament Injuries, Adult, Cells, Cultured, Extracellular Matrix, Humans, Male, Leukocyte Transfusion, Cell Proliferation, Platelet-Rich Plasma, Young Adult

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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