Salivary and serum concentrations of monocyte chemoattractant protein-1, macrophage inhibitory factor, and fractalkine in relation to rheumatoid arthritis and periodontitis
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Background: Monocyte chemoattractant protein‐1 (MCP‐1), macrophage migration inhibitory factor (MIF), and fractalkine are chemokines that are expressed by a variety of cell types to regulate macrophage inflammatory response. The aim of the study was to examine the effects of periodontitis and rheumatoid arthritis (RA) on their serum and salivary concentrations. Methods: Adults with either periodontitis (P, n = 21), or with rheumatoid arthritis (RA, n = 23), or with both diseases (RA+P, n = 23) were included in the study. Systemically and periodontally healthy individuals (n = 22) served as controls. Saliva and serum samples were collected from all participants before the medical and periodontal examinations. Salivary and serum MCP‐1, MIF, and fractalkine concentrations were measured by the Luminex technique. Total salivary protein levels were determined by the Bradford assay. Results: Salivary MCP‐1, MIF, and fractalkine concentrations were elevated in both RA groups (RA+P and RA) in comparison with systemically healthy controls. As related to total salivary protein levels, higher MCP‐1 (P = 0.003) and fractalkine (P = 0.045) concentrations were found in controls compared with the P group. In serum, MCP‐1 concentrations in the RA+P group were higher (P = 0.003) than those of group P. Elevated serum fractalkine concentrations were observed in both periodontitis groups (RA+P, P = 0.014; and P, P = 0.013) compared with controls. Conclusions: In RA, MCP‐1, MIF, and fractalkine concentrations are elevated in saliva. These chemokines may disrupt oral macrophage responses and potentially take part in the interaction between periodontitis and RA.
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In patients with periodontitis and rheumatoid arthritis, CX3CL1 levels are statistically significantly increased compared to systemically and periodontally healthy controls.
“finding a statistically significant increase in their levels compared to their control groups represented by systemically and periodontally healthy patients.”
From Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review (2023) · cites this paper as [169]
Cites
Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal Condition
Silness, J., & Löe, H. (1964) · Acta Odontologica Scandinavica · doi:10.3109/00016356408993968 · Cited by 7,932 · see citing works
Periodontal Disease in Pregnancy I. Prevalence and Severity
Löe, H. A., & Silness, J. (1963) · Acta Odontologica Scandinavica · doi:10.3109/00016356309011240 · Cited by 7,234 · see citing works
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959 · see citing works
Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T. F., Garcia, R., Giannobile, W. V., Graziani, F., et al. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0721 · Cited by 3,202 · see citing works
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
Singh, J. A., Saag, K. G., Bridges, S. L., Akl, E. A., Bannuru, R. R., Sullivan, M. C., Vaysbrot, E. E., McNaughton, C., Osani, M. C., Shmerling, R. H., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39480 · Cited by 2,806 · see citing works
A new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013 · see citing works
Macrophage migration inhibitory factor: a regulator of innate immunity
Calandra, T., & Roger, T. (2003) · Nature reviews. Immunology · doi:10.1038/nri1200 · Cited by 1,782 · see citing works
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
Singh, J. A., Saag, K. G., Bridges, S. L., Akl, E. A., Bannuru, R. R., Sullivan, M. C., Vaysbrot, E. E., McNaughton, C., Osani, M. C., Shmerling, R. H., et al. (2015) · Arthritis Care & Research · doi:10.1002/acr.22783 · Cited by 1,113 · see citing works
Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues
Könönen, E., Gürsoy, M., & Gürsoy, U. K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081135 · Cited by 871 · see citing works
Self-citationThe Bradford Method For Protein Quantitation
Kruger, N. J. (2009) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-59745-198-7_4 · Cited by 779 · see citing works
Ramiro, S., Gaujoux-Viala, C., Nam, J. L., Smolen, J. S., Buch, M. H., Gossec, L., van der Heijde, D. M. F. M., Winthrop, K. L., & Landewé, R. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204575 · Cited by 701 · see citing works
Clinical and public health implications of periodontal and systemic diseases: An overview
Genco, R. J., & Sanz, M. (2020) · Periodontology 2000 · doi:10.1111/prd.12344 · Cited by 694 · see citing works
Mast cells as sources of cytokines, chemokines, and growth factors
Mukai, K., Tsai, M. M., Saito, H., & Galli, S. J. (2018) · Immunological Reviews · doi:10.1111/imr.12634 · Cited by 687 · see citing works
The case for periodontitis in the pathogenesis of rheumatoid arthritis
Potempa, J., Mydel, P. M., & Kozieł, J. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.132 · Cited by 440 · see citing works
Ramiro, S., Sepriano, A. R., Chatzidionysiou, K., Nam, J. L., Smolen, J. S., van der Heijde, D. M. F. M., Dougados, M., van Vollenhoven, R., Bijlsma, J. W. J., Burmester, G. R., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210708 · Cited by 358 · see citing works
Rana, A. K., Li, Y., Dang, Q., & Yang, F. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.10.016 · Cited by 305 · see citing works
Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus
Cooper, G. S., Dooley, M. A., Treadwell, E. L., Clair, E. W. S., Parks, C. G., & Gilkeson, G. S. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199810)41:10 · Cited by 221 · see citing works
The regulation and importance of monocyte chemoattractant protein-1
Bianconi, V., Sahebkar, A., Atkin, S. L., & Pirro, M. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000389 · Cited by 219 · see citing works
Activity loss and the onset of depressive symptoms: Do some activities matter more than others?
Katz, P., & Yelin, E. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200105)44:5 · Cited by 175 · see citing works
Fractalkine: A Novel Angiogenic Chemokine in Rheumatoid Arthritis
Volin, M. V., Woods, J. M., Amin, M. A., Connors, M. A., Harlow, L. A., & Koch, A. E. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62537-0 · Cited by 169 · see citing works
Ebersole, J., Schuster, J. L., Stevens, J., Dawson, D. R., Kryscio, R., Lin, Y.-S., Thomas, M. V., & Miller, C. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9771-3 · Cited by 154 · see citing works
Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption
Koizumi, K., Saitoh, Y., Minami, T., Takeno, N., Tsuneyama, K., Miyahara, T., Nakayama, T., Sakurai, H., Takano, Y., Nishimura, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803627 · Cited by 151 · see citing works
Successes and failures of chemokine-pathway targeting in rheumatoid arthritis
Szekanecz, Z., & Koch, A. E. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.157 · Cited by 142 · see citing works
Cheng, Q., McKeown, S. J., Santos, L. L., Santiago, F. S., Khachigian, L. M., Morand, E. F., & Hickey, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904104 · Cited by 110 · see citing works
Macrophage immunomodulation in chronic osteolytic diseases—the case of periodontitis
Sima, C., Viniegra, A., & Glogauer, M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ru0818-310r · Cited by 106 · see citing works
Proinflammatory role of fractalkine (CX3CL1) in rheumatoid arthritis.
Blaschke, S., Koziolek, M. J., Schwarz, A., Benöhr, P., Middel, P., Schwarz, G., Hummel, K. M., & Muller, G. A. (2003) · PubMed · Cited by 102 · see citing works
Periodontitis and rheumatoid arthritis: An update 2012‐2017
Bartold, P. M., & Lopez‐Oliva, I. (2020) · Periodontology 2000 · doi:10.1111/prd.12300 · Cited by 102 · see citing works
An, Q., Yan, W., Zhao, Y., & Yu, K. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.011 · Cited by 98 · see citing works
Gupta, M., Chaturvedi, R., & Jain, A. R. (2013) · Cytokine · doi:10.1016/j.cyto.2012.12.012 · Cited by 85 · see citing works
Periodontal disease and subgingival microbiota as contributors for rheumatoid arthritis pathogenesis
Scher, J. U., Bretz, W. A., & Abramson, S. B. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000076 · Cited by 83 · see citing works
Boström, E. A., Kindstedt, E., Sulniute, R., Palmqvist, P., Majster, M., Holm, C. K., Zwicker, S., Clark, R., Önell, S., Johansson, I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134608 · Cited by 76 · see citing works
Matsunawa, M., Isozaki, T., Odai, T., Yajima, N., Takeuchi, H. T., Negishi, M., Ide, H., Adachi, M., & Kasama, T. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22208 · Cited by 76 · see citing works
矢野, 隆., Yamamura, M., Sunahori, K., Takasugi, K., Yamana, J., Kawashima, M., & Makino, H. (2007) · PubMed · doi:10.18926/amo/32882 · Cited by 67 · see citing works
Imaging reactive oxygen species dynamics in living cells and tissues
Wu, C.-C. (2009) · Frontiers in Bioscience-Elite · doi:10.2741/e5 · Cited by 63 · see citing works
Oral microbial biofilm stimulation of epithelial cell responses
Peyyala, R., Kirakodu, S. S., Novak, K. F., & Ebersole, J. L. (2012) · Cytokine · doi:10.1016/j.cyto.2011.12.016 · Cited by 59 · see citing works
Salivary cytokine levels in early gingival inflammation
Belstrøm, D., Damgaard, C., Könönen, E., Gürsoy, M., Holmstrup, P., & Gürsoy, U. K. (2017) · Journal of Oral Microbiology · doi:10.1080/20002297.2017.1364101 · Cited by 59 · see citing works
Self-citationHernández-Molina, G., Michel-Peregrina, M. L., Hernández‐Ramírez, D. F., Sánchez‐Guerrero, J., & Llorente, L. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker019 · Cited by 53 · see citing works
Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis
Lira‐Junior, R., Öztürk, V. Ö., Emingil, G., Bostancı, N., & Boström, E. A. (2017) · Journal of Periodontology · doi:10.1902/jop.2017.170287 · Cited by 48 · see citing works
Üstün, K., Ercıyas, K., Kısacık, B., Sezer, U., Pehlivan, Y., Öztuzcu, S., Gündoğar, H., & Onat, A. M. (2013) · Inflammation · doi:10.1007/s10753-013-9652-9 · Cited by 47 · see citing works
Sima, C., & Glogauer, M. (2014) · Current Oral Health Reports · doi:10.1007/s40496-014-0015-x · Cited by 43 · see citing works
Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue
Hosokawa, Y., Nakanishi, T., Yamaguchi, D., Nakae, H., & Matsuo, T. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02675.x · Cited by 39 · see citing works
Llamas-Covarrubias, M. A., Valle, Y., Navarro-Hernández, R. E., Guzmán‐Guzmán, I. P., Ramírez‐Dueñas, M. G., Rangel‐Villalobos, H., Estrada‐Chávez, C., & Muñóz-Valle, J. F. (2011) · Rheumatology International · doi:10.1007/s00296-011-1951-6 · Cited by 37 · see citing works
Panezai, J., Ali, A., Ghaffar, A., Benchimol, D., Altamash, M., Klinge, B., Engström, P.-E., & Larsson, A. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155117 · Cited by 37 · see citing works
Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expression
Hamilton, T. A., Novotny, M., Pavicic, P. G., Herjan, T., Hartupee, J. C., Sun, D., Zhao, C., & Datta, S. (2010) · Cytokine · doi:10.1016/j.cyto.2010.04.003 · Cited by 36 · see citing works
Bae, S., & Lee, Y. H. (2017) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2017-134934 · Cited by 27 · see citing works
Grande, M. A., Belstrøm, D., Damgaard, C., Holmstrup, P., Könönen, E., Gürsoy, M., & Gürsoy, U. K. (2019) · Journal of Oral Microbiology · doi:10.1080/20002297.2019.1694383 · Cited by 21 · see citing works
Self-citationÖzçaka, Ö., Alpöz, E., Nalbantsoy, A., Karabulut, G., & Kabasakal, Y. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0730 · Cited by 18 · see citing works
Gürkan, A., Eren, G., Çetinkalp, Ş., Akçay, Y., Emingil, G., & Atilla, G. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.05.011 · Cited by 16 · see citing works
Rossol, M., Kaltenhäuser, S., Scholz, R., Häntzschel, H., Hauschildt, S., & Wagner, U. G. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1804 · Cited by 14 · see citing works
Brennan-Bourdon, L. M., la Cruz-Mosso, U. D., Reyes-Castillo, Z., Martínez-Bonilla, G., Ramírez‐Dueñas, M. G., Islas-Carbajal, M. C., Rincón‐Sánchez, A. R., Salazar-Páramo, M., & Muñóz-Valle, J. F. (2015) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2015.1017645 · Cited by 11 · see citing works
松縄, 瑞., & 村松, 瑞. (2007) · Cited by 10 · see citing works
Andersen, M., Boesen, M., Ellegaard, K., Söderström, K., Søe, N. H., Spee, P., Mørch, U. G., Torp‐Pedersen, S., Bartels, E. M., Danneskiold‐Samsøe, B., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197001 · Cited by 9 · see citing works
Flagged first, then by citations
3 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Salivary and Serum Inflammatory Biomarkers During Periodontitis Progression and After Treatment
Teles, F., Chandrasekaran, G., Martin, L., Patel, M., Kallan, M., Furquim, C., Hamza, T., Cucchiara, A. J., Kantarcı, A., Urquhart, O., et al. (2024) · Journal of Clinical Periodontology · doi:10.1111/jcpe.14048 · Cited by 68 · see citing works
Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review
Alarcón-Sánchez, M. A., Heboyan, A., Fernandes, G. V. D. O., Castro-Alarcón, N., & Romero-Castro, N. S. (2023) · Molecules · doi:10.3390/molecules28031075 · Cited by 52 · see citing works
Connection between oral health and chronic diseases
Fu, D., Shu, X., Zhou, G., Ji, M., Liao, G., & Zou, L. (2025) · MedComm · doi:10.1002/mco2.70052 · Cited by 43 · see citing works
Ambient fine particulate matter exposures and human early placental inflammation
Gong, C., Chu, M., Yang, J., Gong, X., Han, B., Chen, L., Bai, Z., Wang, J., & Zhang, Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120446 · Cited by 34 · see citing works
Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases
Lopez‐Oliva, I., Malcolm, J., & Culshaw, S. (2024) · Periodontology 2000 · doi:10.1111/prd.12530 · Cited by 17 · see citing works
Serum cytokines in periodontal diseases
Ahmad, P., Slots, J., & Siqueira, W. L. (2025) · Periodontology 2000 · doi:10.1111/prd.12629 · Cited by 17 · see citing works
Alarcón‐Sánchez, M. A., Becerra‐Ruiz, J. S., Velázquez, C. G., Mosaddad, S. A., & Heboyan, A. G. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1181 · Cited by 15 · see citing works
Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis
Yılmaz, D., Niskanen, K., Gonullu, E. O., Tervahartiala, T. I., Gürsoy, U. K., & Sorsa, T. A. (2023) · Oral Diseases · doi:10.1111/odi.14574 · Cited by 14 · see citing works
Self-citationFang, T., Liu, L., Mao, S., Jiang, Z., Cao, Y., & Pan, J. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29784 · Cited by 12 · see citing works
Impact of dietary inflammatory index on gingival health
Reis, R. A., Stolf, C. S., Sampaio, H. A. D. C., Silva, B. Y. D. C., Karahan, T. Ö., Kenger, E. B., Miguel, M. M. V., Santamaria, M. P., Monteiro, M. F., Casati, M. Z., et al. (2023) · Journal of Periodontology · doi:10.1002/jper.23-0292 · Cited by 11 · see citing works
M2 macrophages with inflammation tropism facilitate cementoblast mineralization
Huang, X., Wang, X., Ma, L., Wang, H., Peng, Y., Liu, H., Xiao, J., & Cao, Z. (2022) · Journal of Periodontology · doi:10.1002/jper.22-0048 · Cited by 10 · see citing works
The role of MIF in periodontitis: A potential pathogenic driver, biomarker, and therapeutic target
Fang, T., Liu, L., Song, D., & Huang, D. (2023) · Oral Diseases · doi:10.1111/odi.14558 · Cited by 9 · see citing works
Alarcón‐Sánchez, M. A., Castro-Alarcón, N., Sandoval-Guevara, D., Vázquez-Villamar, M., FERNÁNDEZ-ACOSTA, K., MÉNDEZ-GÓMEZ, M. Y., Parra‐Rojas, I., & Romero-Castro, N. S. (2024) · Dental Materials Journal · doi:10.4012/dmj.2023-136 · Cited by 5 · see citing works
Alarcón‐Sánchez, M. A., Montaño, R. R., Martínez, S. M. L., & Heboyan, A. G. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70545 · Cited by 4 · see citing works
Chen, W., Yu, Y., Zheng, S. G., & Lin, J. (2023) · Rheumatology & autoimmunity · doi:10.1002/rai2.12075 · Cited by 4 · see citing works
Yang, J., Li, X., Chu, M., Wang, M., Huo, Y., Han, B., Bai, Z., Wang, J., & Zhang, Y. (2025) · Environmental Health Perspectives · doi:10.1289/ehp15170 · Cited by 3 · see citing works
Tang, Y., Gao, S., Wang, Y., Liang, W., Jin, S., Weng, Y., Xia, Y., & Ma, J. (2025) · British Journal of Hospital Medicine · doi:10.12968/hmed.2025.0447 · Cited by 2 · see citing works
Linlin, Z., Yumei, Z., Wenting, L. U., Yanan, S., Guo, Y.-D., Xiaochao, L., Chen, Y., Kun, L., Danhui, H. U., HuiLing, Y., et al. (2024) · PubMed Central · doi:10.19852/j.cnki.jtcm.20220602.001 · Cited by 2 · see citing works
Wang, C., Rong, X., Dong, T., Zhu, J., Wang, F., Shao, P., & Jiang, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165723
Molecular marker discovery and detection for blinding eye disease
Gao, S., Guo, D., Huang, P., Yin, N., Jia, H., Li, S., Sun, X., & Zhu, X. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03627-0
HAMURCU, N., Çörekci, A. U., Sağkan, R. I., Cula, S., & ÇETINER, D. Ö. (2025) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2025-0304
- Authors
- Yilmaz, D., Gönüllü, E., Gürsoy, M., Könönen, E., & Gürsoy, U. K.
- Affiliations
- Department of Periodontology, Faculty of Dentistry Sakarya University Sakarya Turkey
- Department of Rheumatology, Faculty of Medicine Sakarya University Sakarya Turkey
- University of Turku (FI)
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 2021-01-03
- Volume
- 92
- Issue
- 9
- Pages
- 1295-1305
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W3112490268
- Cited by
- 21
- References
- 55
- Citations by year
- 2025: 8 · 2024: 6 · 2023: 5 · 2022: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.utupub.fi
- Locations
- Journal of Periodontology (publishedVersion)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Sakarya Üniversitesi Kurumsal Açık Akademik Arşivi (submittedVersion)
- Funders
- Suomen Hammaslääkäriseura Apollonia
- Turun Yliopisto
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- MCP-1, macrophage migration inhibitory factor, fractalkine, chemokines, rheumatoid arthritis, periodontitis, salivary biomarkers, serum biomarkers
- MeSH terms
- Arthritis, Rheumatoid, Humans, Macrophage Migration-Inhibitory Factors, Periodontitis, Chemokine CCL2, Intramolecular Oxidoreductases, Chemokine CX3CL1
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