The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Role of BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in Drug Development
Open accessAbstract
BCS and BDDCS are complimentary, not competing, classification systems that aim to improve, simplify, and speed drug development. Although both systems are based on classifying drugs and NMEs into four categories using the same solubility criteria, they differ in the criterion for permeability and have different purposes. Here the details and applications of both systems are reviewed with particular emphasis of their role in drug development.
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Cites
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Self-citationSconce, E. A., Khan, T. I., Wynne, H. A., Avery, P., Monkhouse, L., King, B. P., Wood, P., Kesteven, P., Daly, A. K., & Kamali, F. (2005) · Blood · doi:10.1182/blood-2005-03-1108 · Cited by 947
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BDDCS Applied to Over 900 Drugs
Benet, L. Z., Broccatelli, F., & Oprea, T. I. (2011) · The AAPS Journal · doi:10.1208/s12248-011-9290-9 · Cited by 626
Self-citationWager, T. T., Chandrasekaran, R. Y., Hou, X., Troutman, M. D., Verhoest, P. R., Villalobos, A., & Will, Y. (2010) · ACS Chemical Neuroscience · doi:10.1021/cn100007x · Cited by 477
The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
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Self-citationCustodio, J. M., Wu, C.-Y., & Benet, L. Z. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.043 · Cited by 434
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Cited by
BDDCS, the Rule of 5 and drugability
Benet, L. Z., Hosey, C. M., Ursu, O., & Oprea, T. I. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.05.007 · Cited by 892
Self-citationPolymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs
Censi, R., & Di Martino, P. (2015) · Molecules · doi:10.3390/molecules201018759 · Cited by 512
Gastrointestinal malabsorption of thyroxine
Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164
Verma, S., Goand, U. K., Husain, A., Katekar, R. A., Garg, R., & Gayen, J. R. (2021) · Drug Development Research · doi:10.1002/ddr.21832 · Cited by 151
Regional intestinal drug permeation: Biopharmaceutics and drug development
Lennernäs, H. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.08.025 · Cited by 103
Metadata
- Authors
- Benet, L. Z.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 102
- Issue
- 1
- Pages
- 34-42
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2057584545
- Cited by
- 342
- References
- 35
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Role of BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in Drug Development. https://app.cochat.ai/papers/10.1002/jps.23359
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- Benet, L. Z. (2013). The Role of BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in Drug Development. Journal of Pharmaceutical Sciences. https://doi.org/10.1002/jps.23359
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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