The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
BDDCS, the Rule of 5 and drugability
Open accessAbstract
The rule of 5 methodology appears to be as useful today in defining drugability as when it was proposed, but recognizing that the database that we used includes only drugs that successfully reached the market. We do not view additional criteria necessary nor did we find significant deficiencies in the four Rule of 5 criteria originally proposed by Lipinski and coworkers. BDDCS builds upon the Rule of 5 and can quite successfully predict drug disposition characteristics for drugs both meeting and not meeting Rule of 5 criteria. More recent expansions of classification systems have been proposed and do provide useful qualitative and quantitative predictions for clearance relationships. However, the broad range of applicability of BDDCS beyond just clearance predictions gives a great deal of further usefulness for the combined Rule of 5/BDDCS system.
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Cites
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Drug-like properties and the causes of poor solubility and poor permeability
Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,734
Membrane transporters in drug development
The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3028 · Cited by 3,340
Self-citationAn analysis of the attrition of drug candidates from four major pharmaceutical companies
Waring, M. J., Arrowsmith, J., Leach, A. R., Leeson, P. D., Mandrell, S., Owen, R. M., Pairaudeau, G., Pennie, W. D., Pickett, S. D., Wang, J., et al. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4609 · Cited by 1,450
Wu, C.-Y., & Benet, L. Z. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-9004-4 · Cited by 1,401
Self-citationImpact of OATP transporters on pharmacokinetics
Kalliokoski, A., & Niemi, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00430.x · Cited by 995
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Self-citation(2001) · Drugs and the Pharmaceutical Sciences · doi:10.1201/9780824741969.axh · Cited by 818
Property distribution of drug-related chemical databases*
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Artificial Intelligence for Drug Discovery: Are We There Yet?
Hasselgren, C., & Oprea, T. I. (2024) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-040323-040828 · Cited by 236
“It is undeniable that Ro5 criteria have had a significant impact on medicinal chemistry (180).”
BackgroundSelf-citationEladl, O. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117297 · Cited by 44
Khadke, S. K., Lee, J.-H., Kim, Y.-G., Raj, V., & Lee, J. (2021) · Biomedicines · doi:10.3390/biomedicines9091133 · Cited by 33
Connor, S., Li, T., Qu, Y., Roberts, R. A., & Tong, W. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.103938 · Cited by 21
Avram, S., Curpan, R., Halip, L., Bora, A., & Oprea, T. I. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00826 · Cited by 18
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Metadata
- Authors
- Benet, L. Z., Hosey, C. M., Ursu, O., & Oprea, T. I.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 101
- Pages
- 89-98
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2379628571
- Cited by
- 892
- References
- 54
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Benet, L. Z., Hosey, C. M., Ursu, O., & Oprea, T. I. (2016). BDDCS, the Rule of 5 and drugability. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2016.05.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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