Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

Hoshi, Yutaro, Uchida, Yasuo, Tachikawa, Masanori, Inoue, Takashi, Ohtsuki, Sumio, Terasaki, Tetsuya·2013·Journal of Pharmaceutical Sciences

Cited by (259)

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  56. Species Differences and Impact of Disease State on BBB
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  57. Modeling the Blood–Brain Barrier to Understand Drug Delivery in Alzheimer’s Disease
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