Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917 · see citing works

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

Uchida, Y., Ohtsuki, S., Katsukura, Y., Ikeda, C., Suzuki, T., Kamiie, J., & Terasaki, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07208.x · Cited by 881 · see citing works

Brain metabolism: a perspective from the blood-brain barrier

Pardridge, W. M. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.4.1481 · Cited by 743 · see citing works

Generation of transgenic non-human primates with germline transmission

Sasaki, E., Suemizu, H., Shimada, A., Hanazawa, K., Oiwa, R., Kamioka, M., Tomioka, I., Sotomaru, Y., Hirakawa, R., Eto, T., et al. (2009) · Nature · doi:10.1038/nature08090 · Cited by 712 · see citing works

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

Kamiie, J., Ohtsuki, S., Iwase, R., Ohmine, K., Katsukura, Y., 矢内一成, Yumi, S., Uchida, Y., Ito, S., & Terasaki, T. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9532-4 · Cited by 480 · see citing works

Contribution of Carrier-Mediated Transport Systems to the Blood–Brain Barrier as a Supporting and Protecting Interface for the Brain; Importance for CNS Drug Discovery and Development

Ohtsuki, S., & Terasaki, T. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9374-5 · Cited by 456 · see citing works

Isotope-labeled Protein Standards

Brun, V., Dupuis, A., Adrait, A., Marcellin, M., Thomas, D. Y., Court, M., Vandenesch, F., & Garin, J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700163-mcp200 · Cited by 443 · see citing works

Neurological Diseases in Relation to the Blood–Brain Barrier

Rosenberg, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.197 · Cited by 442 · see citing works

Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

Ohtsuki, S., Schaefer, O., Kawakami, H., Inoue, T., Liehner, S., Saito, A., Ishiguro, N., Kishimoto, W., Ludwig-Schwellinger, E., Ebner, T., et al. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.042259 · Cited by 433 · see citing works

X-Linked Creatine-Transporter Gene (SLC6A8) Defect: A New Creatine-Deficiency Syndrome

Salomons, G. S., van Dooren, S. J. M., Verhoeven‐Duif, N. M., Cecil, K. M., Ball, W. S., deGrauw, T. J., & Jakobs, C. (2001) · The American Journal of Human Genetics · doi:10.1086/320595 · Cited by 395 · see citing works

Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain

Nies, A. T., Jedlitschky, G., König, J., Herold‐Mende, C. C., Steiner, H. H., Schmitt, H.-P., & KEPPLER, D. O. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.051 · Cited by 381 · see citing works

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

Syvänen, S., Lindhe, Ö., Palner, M., Kornum, B. R., Rahman, O., Långström, B., Knudsen, G. M., & Hammarlund‐Udenaes, M. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.024745 · Cited by 361 · see citing works

A Quantitative Study of the Effects of Chaotropic Agents, Surfactants, and Solvents on the Digestion Efficiency of Human Plasma Proteins by Trypsin

Proc, J. L., Kuzyk, M. A., Hardie, D. B., Yang, J., SMITH, D. S. H., Jackson, A., Parker, C. E., & Borchers, C. H. (2010) · Journal of Proteome Research · doi:10.1021/pr100656u · Cited by 354 · see citing works

Isotope dilution strategies for absolute quantitative proteomics

Brun, V., Masselon, C., Garin, J., & Dupuis, A. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.03.007 · Cited by 314 · see citing works

Several major antiepileptic drugs are substrates for human P-glycoprotein

Luna‐Tortós, C., Fedrowitz, M., & Löscher, W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.032 · Cited by 310 · see citing works

Cerebral ketone body metabolism

Morris, A. A. M. (2004) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-5518-0 · Cited by 300 · see citing works

Dominant‐negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S‐S dependent homodimerization

Kage, K., Tsukahara, S., Sugiyama, T., Asada, S., Ishikawa, E., Tsuruo, T., & Sugimoto, Y. (2001) · International Journal of Cancer · doi:10.1002/ijc.10100 · Cited by 290 · see citing works

Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

Roberts, L. M., Black, D. S., Raman, C., Woodford, K., Zhou, M., Haggerty, J. E., Yan, A. T., Cwirla, S. E., & Grindstaff, K. K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.015 · Cited by 240 · see citing works

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human

Warren, M. S., Zerangue, N., Woodford, K., Roberts, L. M., Tate, E. H., Feng, B., Li, C., Feuerstein, T. J., Gibbs, J. P., & Smith, B. J. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.007 · Cited by 240 · see citing works

Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys

Ito, K., Uchida, Y., Ohtsuki, S., Aizawa, S., Kawakami, H., Katsukura, Y., Kamiie, J., & Terasaki, T. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22487 · Cited by 231 · see citing works

The common marmoset as a novel animal model system for biomedical and neuroscience research applications

Okano, H., Hikishima, K., Iriki, A., & Sasaki, E. (2012) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2012.07.002 · Cited by 218 · see citing works

Reengineering Biopharmaceuticals for Targeted Delivery Across the Blood–Brain Barrier

Pardridge, W. M., & Boado, R. J. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-396962-0.00011-2 · Cited by 199 · see citing works

The Blood???Brain Barrier Creatine Transporter Is a Major Pathway for Supplying Creatine to the Brain

Ohtsuki, S., Tachikawa, M., Takanaga, H., Shimizu, H., Watanabe, M., Hosoya, K., & Terasaki, T. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000033966.83623.7d · Cited by 198 · see citing works

Rat Organic Anion Transporter 3 (rOAT3) Is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells

Mori, S., Takanaga, H., Ohtsuki, S., Deguchi, T., Kang, Y., Hosoya, K., & Terasaki, T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000050062.57184.75 · Cited by 172 · see citing works

Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK‐Mi and CK‐B suggest a novel neuron–glial relationship for brain energy homeostasis

Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., & Watanabe, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03478.x · Cited by 172 · see citing works

Effects of Modified Digestion Schemes on the Identification of Proteins from Complex Mixtures

Klammer, A. A., & MacCoss, M. J. (2006) · Journal of Proteome Research · doi:10.1021/pr050315j · Cited by 165 · see citing works

mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting

Ohtsuki, S., Yamaguchi, H., Katsukura, Y., Asashima, T., & Terasaki, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05008.x · Cited by 161 · see citing works

Establishment of Novel Embryonic Stem Cell Lines Derived from the Common Marmoset ( Callithrix jacchus )

Sasaki, E., Hanazawa, K., Kurita, R., Akatsuka, A., Yoshizaki, T., Ishii, H., Tanioka, Y., Ohnishi, Y., Suemizu, H., Sugawara, A., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0366 · Cited by 155 · see citing works

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

Cannon, R. E., Peart, J. C., Hawkins, B. T., Campos, C. R., & Miller, D. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203534109 · Cited by 141 · see citing works

Quantitative Targeted Absolute Proteomics-Based Adme Research as A New Path to Drug Discovery and Development: Methodology, Advantages, Strategy, and Prospects

Ohtsuki, S., Uchida, Y., Kubo, Y., & Terasaki, T. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22612 · Cited by 137 · see citing works

Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy

Cornford, E. M., & Hyman, S. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.27 · Cited by 132 · see citing works

Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate

Kodaira, H., Kusuhara, H., Fujita, T., Ushiki, J., Fuse, E., & Sugiyama, Y. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.180398 · Cited by 132 · see citing works

Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28

Tomioka, I., Maeda, T., Shimada, H., Kawai, K., Okada, Y., Igarashi, H., Oiwa, R., Iwasaki, T., Aoki, M., Kimura, T., et al. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01437.x · Cited by 131 · see citing works

Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice

Uchida, Y., Ohtsuki, S., Kamiie, J., & Terasaki, T. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.184200 · Cited by 131 · see citing works

Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp Knockout Mice

Agarwal, S., Uchida, Y., Mittapalli, R. K., Sane, R., Terasaki, T., & Elmquist, W. F. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.044719 · Cited by 127 · see citing works

Kinetic Analyses for Species Differences in P-glycoprotein-Mediated Drug Transport

Katoh, M., Suzuyama, N., Takeuchi, T., Yoshitomi, S., Asahi, S., & Yokoi, T. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20686 · Cited by 109 · see citing works

Phosphorylation of the Na+,K+‐ATPase and the H+,K+‐ATPase

Poulsen, H., Morth, J. P., Egebjerg, J., & Nissen, P. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.035 · Cited by 99 · see citing works

1 H NMR Studies of Glucose Transport in the Human Brain

Rolf Gruetter, A., Novotny, E. J., Boulware, S. D., Rothman, D. L., & Shulman, R. G. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199605000-00009 · Cited by 98 · see citing works

In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [11C]Verapamil

Lee, Y. J., Maeda, J., Kusuhara, H., Okauchi, T., Inaji, M., Nagai, Y., Obayashi, S., Nakao, R., Suzuki, K., Sugiyama, Y., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.088328 · Cited by 91 · see citing works

Organic anion transporter 3 is involved in the brain‐to‐blood efflux transport of thiopurine nucleobase analogs

Mori, S., Ohtsuki, S., Takanaga, H., Kikkawa, T., Kang, Y., & Terasaki, T. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02552.x · Cited by 90 · see citing works

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics

Zamek‐Gliszczynski, M. J., Bedwell, D. W., Bao, J., & Higgins, J. W. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.046508 · Cited by 90 · see citing works

Verapamil P-glycoprotein Transport across the Rat Blood-Brain Barrier: Cyclosporine, a Concentration Inhibition Analysis, and Comparison with Human Data

Hsiao, P., Sasongko, L., Link, J. M., Mankoff, D. A., Muzi, M., Collier, A. C., & Unadkat, J. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097931 · Cited by 89 · see citing works

Overview of the marmoset as a model in nonclinical development of pharmaceutical products

Orsi, A., Rees, D. D., Andreini, I., Venturella, S., Cinelli, S., & Oberto, G. (2010) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2010.12.003 · Cited by 70 · see citing works

Simultaneous measurement of glucose transport and utilization in the human brain

Shestov, A. A., Emir, U. E., Kumar, A. F., Henry, P., Seaquist, E. R., & Öz, G. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2011 · Cited by 60 · see citing works

Membrane Protein Quantification by Peptide-Based Mass Spectrometry Approaches: Studies on the Organic Anion-Transporting Polypeptide Family

Balogh, L. M. (2013) · Journal of Proteomics & Bioinformatics · doi:10.4172/jpb.1000285 · Cited by 56 · see citing works

Production and Use of Stable Isotope-Labeled Proteins for Absolute Quantitative Proteomics

Lebert, D., Dupuis, A., Garin, J., Bruley, C., & Brun, V. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-148-2_7 · Cited by 51 · see citing works

The blood–brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters

Tachikawa, M., Kasai, Y., Yokoyama, R., Fujinawa, J., Ganapathy, V., Terasaki, T., & Hosoya, K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06332.x · Cited by 48 · see citing works

The β3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test

LaCroix‐Fralish, M. L., Mo, G., Smith, S. B., Sotocinal, S. G., Ritchie, J., Austin, J., Melmed, K. R., Schorscher-Petcu, A., Laferrière, A., Lee, T. H., et al. (2009) · Pain · doi:10.1016/j.pain.2009.04.028 · Cited by 45 · see citing works

Quantitative Targeted Absolute Proteomics-Based Large-Scale Quantification of Proline-Hydroxylated α-Fibrinogen in Plasma for Pancreatic Cancer Diagnosis

Yoneyama, T., Ohtsuki, S., Ono, M., Ohmine, K., Uchida, Y., Yamada, T., Tachikawa, M., & Terasaki, T. (2013) · Journal of Proteome Research · doi:10.1021/pr3008144 · Cited by 39 · see citing works

Effects of Lamotrigine on Electrically Induced Afterdischarge Duration in Anaesthetised Rat, Dog, and Marmoset

Wheatley, P. L., & Miller, A. A. (1989) · Epilepsia · doi:10.1111/j.1528-1157.1989.tb05277.x · Cited by 37 · see citing works

Involvement of Multidrug Resistance-Associated Protein 4 in Efflux Transport of Prostaglandin E2 across Mouse Blood-Brain Barrier and Its Inhibition by Intravenous Administration of Cephalosporins

Akanuma, S., Hosoya, K., Ito, S., Tachikawa, M., Terasaki, T., & Ohtsuki, S. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.165332 · Cited by 36 · see citing works

Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate

Perez‐Mendes, P., Blanco, M. M., Calcagnotto, M. E., Cinini, S. M., Bachiega, J. C., Papoti, D., Covolan, L., Tannús, A., & Mello, L. E. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.04.015 · Cited by 34 · see citing works

Establishing a Method to Isolate Rat Brain Capillary Endothelial Cells by Magnetic Cell Sorting and Dominant mRNA Expression of Multidrug Resistance-associated Protein 1 and 4 in Highly Purified Rat Brain Capillary Endothelial Cells

Ohtsuki, S., Yamaguchi, H., Asashima, T., & Terasaki, T. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9188-x · Cited by 33 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

Tietz, S., & Engelhardt, B. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412147 · Cited by 551 · see citing works

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

Pardridge, W. M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00373 · Cited by 405 · see citing works

Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects

Haseloff, R. F., Dithmer, S., Winkler, L., Wolburg, H., & Blasig, I. E. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.11.004 · Cited by 353 · see citing works

Bridging barriers: a comparative look at the blood–brain barrier across organismsPreprint

O’Brown, N. M., Pfau, S. J., & Gu, C. (2018) · Genes & Development · doi:10.1101/gad.309823.117 · Cited by 261 · see citing works

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219 · see citing works

In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain

Wilhelm, I., & Krizbai, I. A. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500046f · Cited by 211 · see citing works

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Hladky, S. B., & Barrand, M. A. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0113-6 · Cited by 206 · see citing works

L-Type amino acid transporter 1 as a target for drug delivery

Puris, E., Gynther, M., Auriola, S. O. K., & Huttunen, K. M. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02826-8 · Cited by 206 · see citing works

SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers

Morris, M., Rodriguez-Cruz, V., & Felmlee, M. (2017) · AAPS Journal · doi:10.1208/s12248-017-0110-8 · Cited by 155 · see citing works

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

Aday, S., Cecchelli, R., Hallier-Vanuxeem, D., Dehouck, M. P., & Ferreira, L. (2016) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.01.001 · Cited by 169 · see citing works

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

Pardridge, W. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1042364 · Cited by 159 · see citing works

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers

Dias, M. C., Mapunda, J. A., Vladymyrov, M., & Engelhardt, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215372 · Cited by 152 · see citing works

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms

Oksanen, M., Lehtonen, Š., Jaronen, M., Goldsteins, G., Hämäläinen, R. H., & Koıstınaho, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03111-7 · Cited by 156 · see citing works

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis

Ribecco-Lutkiewicz, M., Sodja, C., Haukenfrers, J., Haqqani, A. S., Ly, D., Zachar, P., Baumann, E., Ball, M., Huang, J., Rukhlova, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-19522-8 · Cited by 148 · see citing works

Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology

Pardridge, W. M. (2017) · BioDrugs · doi:10.1007/s40259-017-0248-z · Cited by 152 · see citing works

Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport

Veszelka, S., Tóth, A., Walter, F. R., Tóth, A. E., Gróf, I., Mészáros, M., Bocsik, A., Hellinger, É., Vastag, M., Rákhely, G., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00166 · Cited by 133 · see citing works

Recent advances in human iPSC-derived models of the blood–brain barrier

Workman, M. J., & Svendsen, C. N. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00191-7 · Cited by 131 · see citing works

Proteomic Quantification of Human Blood–Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

Al‐Majdoub, Z. M., Feteisi, H. A., Achour, B., Warwood, S., Neuhoff, S., Rostami‐Hodjegan, A., & Barber, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01189 · Cited by 125 · see citing works

ABC Transporters at the Blood–Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas

Gomez‐Zepeda, D., Taghi, M., Scherrmann, J., Declèves, X., & Menet, M. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010020 · Cited by 124 · see citing works

Major involvement of Na + ‐dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells

Uchida, Y., Ito, K., Ohtsuki, S., Kubo, Y., Suzuki, T., & Terasaki, T. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13092 · Cited by 115 · see citing works

Quantitative targeted absolute proteomics of rat blood–cerebrospinal fluid barrier transporters: comparison with a human specimen

Uchida, Y., Zhang, Z., Tachikawa, M., & Terasaki, T. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13147 · Cited by 108 · see citing works

Apicobasal polarity of brain endothelial cells

Worzfeld, T., & Schwaninger, M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15608644 · Cited by 102 · see citing works

Claudin-3-deficient C57BL/6J mice display intact brain barriers

Dias, M. C., Coisne, C., Lazarevic, I., Baden, P., Hata, M., Iwamoto, N., Francisco, D. M. F., Vanlandewijck, M., He, L., Baier, F. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36731-3 · Cited by 100 · see citing works

Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis

Uchida, Y., Sumiya, T., Tachikawa, M., Yamakawa, T., Murata, S., Yagi, Y., Sato, K., Stephan, A., Ito, K., Ohtsuki, S., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1207-5 · Cited by 97 · see citing works

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat

Welbat, J. U., Naewla, S., Pannangrong, W., Sirichoat, A., Aranarochana, A., & Wigmore, P. M. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114083 · Cited by 83 · see citing works

How Glutamate Is Managed by the Blood–Brain Barrier

Hawkins, R. A., & Vinã, J. R. (2016) · Biology · doi:10.3390/biology5040037 · Cited by 82 · see citing works

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

Kubo, Y., Ohtsuki, S., Uchida, Y., & Terasaki, T. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24398 · Cited by 81 · see citing works

Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters

Grube, M., Hagen, P., & Jedlitschky, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00354 · Cited by 75 · see citing works

Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models

Ting, K. K., Coleman, P. R., Kim, H. J., Zhao, Y., Mulangala, J., Cheng, N. C., Li, W., Gunatilake, D., Johnstone, D. M., Loo, L., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00927-x · Cited by 79 · see citing works

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier

Erdő, F., & Krajcsi, P. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00196 · Cited by 77 · see citing works

In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain

Modarres, H. P., Janmaleki, M., Novin, M., Saliba, J., Moussa, F. E. H., Charan, M. R., Seyfoori, A., SadAbadi, H., Vandal, M., Nguyen, M. D., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.024 · Cited by 73 · see citing works

Comparison of Absolute Protein Abundances of Transporters and Receptors among Blood–Brain Barriers at Different Cerebral Regions and the Blood–Spinal Cord Barrier in Humans and Rats

Uchida, Y., Yagi, Y., Takao, M., Tano, M., Umetsu, M., Hirano, S., Usui, T., Tachikawa, M., & Terasaki, T. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00178 · Cited by 72 · see citing works

Engineering the human blood-brain barrier in vitro

Jamieson, J. J., Searson, P. C., & Gerecht, S. (2017) · Journal of Biological Engineering · doi:10.1186/s13036-017-0076-1 · Cited by 71 · see citing works

Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels

Feteisi, H. A., Al‐Majdoub, Z. M., Achour, B., Couto, N. A. S., Rostami‐Hodjegan, A., & Barber, J. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14446 · Cited by 70 · see citing works

Engineering antibody and protein therapeutics to cross the blood–brain barrier

Zhao, P., Zhang, N., & An, Z. (2022) · Antibody Therapeutics · doi:10.1093/abt/tbac028 · Cited by 71 · see citing works

P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model

Adkins, C. E., Mittapalli, R. K., Manda, V. K., Nounou, M. I., Mohammad, A. S., Terrell, T. B., Bohn, K. A., Celik, Y., Grothe, T. R., Lockman, J. A., et al. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00136 · Cited by 70 · see citing works

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems.

Liu, H., Dong, K., Zhang, W.-D., Summerfield, S., & Terstappen, G. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.03.002 · Cited by 59 · see citing works

Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells

Kurosawa, T., Tega, Y., Higuchi, K., Yamaguchi, T., Nakakura, T., Mochizuki, T., Kusuhara, H., Kawabata, K., & Deguchi, Y. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00697 · Cited by 67 · see citing works

Peripheral Inflammation and Insulin Resistance: Their Impact on Blood–Brain Barrier Integrity and Glia Activation in Alzheimer’s Disease

Ponce-Lopez, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094209 · Cited by 75 · see citing works

Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood–Brain Barrier—Towards a Mechanistic IVIVE-Based Approach

Ball, K., Bouzom, F., Scherrmann, J., Walther, B., & Declèves, X. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9496-0 · Cited by 63 · see citing works

Effects of Selected OATP and/or ABC Transporter Inhibitors on the Brain and Whole-Body Distribution of Glyburide

Tournier, N., Saba, W., Cisternino, S., Peyronneau, M., Damont, A., Goutal, S., Dubois, A., Dollé, F., Scherrmann, J., Valette, H., et al. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9514-2 · Cited by 62 · see citing works

The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery

Cox, B., Nicolaï, J., & Williamson, B. (2022) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2331 · Cited by 61 · see citing works

Critical Issues and Optimized Practices in Quantification of Protein Abundance Level to Determine Interindividual Variability in DMET Proteins by LC‐MS/MS Proteomics

Bhatt, D. K., & Prasad, B. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.819 · Cited by 61 · see citing works

Blood-Brain Barrier Pharmacoproteomics-Based Reconstruction of the In Vivo Brain Distribution of P-Glycoprotein Substrates in Cynomolgus Monkeys

Uchida, Y., Wakayama, K., Ohtsuki, S., Chiba, M., Ohe, T., Ishii, Y., & Terasaki, T. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214536 · Cited by 60 · see citing works

Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood–Brain Barrier

Bauer, M., Römermann, K., Karch, R., Wulkersdorfer, B., Stanek, J., Philippe, C., Maier‐Salamon, A., Haslacher, H., Jungbauer, C., Wadsak, W., et al. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.362 · Cited by 60 · see citing works

Quantification of Transporter and Receptor Proteins in Dog Brain Capillaries and Choroid Plexus: Relevance for the Distribution in Brain and CSF of Selected BCRP and P-gp Substrates

Braun, C., Sakamoto, A., Fuchs, H., Ishiguro, N., Suzuki, S., Cui, Y., Klinder, K., Watanabe, M., Terasaki, T., & Sauer, A. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00449 · Cited by 58 · see citing works

Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke

Nilles, K. L., Williams, E. I., Betterton, R. D., Davis, T. P., & Ronaldson, P. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031898 · Cited by 56 · see citing works

Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies

Pardridge, W. M. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1230195 · Cited by 55 · see citing works

Transport of nanomedicines across the blood-brain barrier: Challenges and opportunities for imaging and therapy

van den Broek, S. L., Shalgunov, V., & Herth, M. M. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213125 · Cited by 56 · see citing works

In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier

Trapa, P. E., Troutman, M. D., Lau, T. Y. K., Wager, T. T., Maurer, T. S., Patel, N. C., West, M. A., Umland, J. P., Carlo, A. A., Feng, B., et al. (2019) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.083279 · Cited by 53 · see citing works

Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies

Lu, T. M., Durán, J. G. B., Houghton, S., Rafii, S., Redmond, D., & Lis, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.642812 · Cited by 53 · see citing works

Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging

Ford, J. N., Zhang, Q., Sweeney, E. M., Merkler, A. E., de Leon, M. J., Gupta, A. K., Nguyen, T. D., & Ivanidze, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.867452 · Cited by 52 · see citing works

Drug Transporters in the Central Nervous System

Stieger, B., & Gao, B. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0241-y · Cited by 51 · see citing works

Human iPSC‐Derived Blood‐Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development?

Appelt‐Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., & Pleß, O. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.122 · Cited by 54 · see citing works

The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier

Pardridge, W. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00398 · Cited by 51 · see citing works

The impact of ATP-binding cassette transporters in the diseased brain: Context matters

Baltira, C., Aronica, E., Elmquist, W. F., Langer, O., Löscher, W., Sarkaria, J. N., Wesseling, P., de Gooijer, M. C., & van Tellingen, O. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101609 · Cited by 50 · see citing works

Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer’s Disease and the Clinical Significance

Jia, Y., Wang, N., Zhang, Y., Xue, D., Lou, H., & Liu, X. (2020) · Aging and Disease · doi:10.14336/ad.2019.0519 · Cited by 45 · see citing works

Quantitative targeted proteomics for understanding the blood–brain barrier: towards pharmacoproteomics

Ohtsuki, S., Hirayama, M., Ito, S., Uchida, Y., Tachikawa, M., & Terasaki, T. (2014) · Expert Review of Proteomics · doi:10.1586/14789450.2014.893830 · Cited by 45 · see citing works

Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal Models

Feng, B., Doran, A. C., Di, L., West, M. A., Osgood, S. M., Mancuso, J. Y., Shaffer, C. L., Tremaine, L. M., & Liras, J. L. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.03.018 · Cited by 45 · see citing works

Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood–brain barrier

Hoshi, Y., Uchida, Y., Tachikawa, M., Ohtsuki, S., Couraud, P., Suzuki, T., & Terasaki, T. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18822801 · Cited by 44 · see citing works

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Huttunen, K., Terasaki, T., Urtti, A., Montaser, A. B., & Uchida, Y. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03193-2 · Cited by 31 · see citing works

A critical assessment of in vitro tissue models for ADME and drug delivery

Vellonen, K., Malinen, M. M., Mannermaa, E., Subrizi, A., Toropainen, E., Lou, Y., Kidron, H., Yliperttula, M. L., & Urtti, A. O. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.044 · Cited by 42 · see citing works

Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration

Watanabe, R., Esaki, T., Ohashi, R., Kuroda, M., Kawashima, H., Komura, H., Natsume‐Kitatani, Y., & Mizuguchi, K. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02011 · Cited by 42 · see citing works

Contribution of Pannexin 1 and Connexin 43 Hemichannels to Extracellular Calcium–Dependent Transport Dynamics in Human Blood-Brain Barrier Endothelial Cells

Kaneko, Y., Tachikawa, M., Akaogi, R., Fujimoto, K., Ishibashi, M., Uchida, Y., Couraud, P., Ohtsuki, S., Hosoya, K., & Terasaki, T. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.220210 · Cited by 41 · see citing works

Metabolite transport across the mammalian and insect brain diffusion barriers

Weiler, A., Volkenhoff, A., Hertenstein, H., & Schirmeier, S. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.008 · Cited by 42 · see citing works

Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of Rats

Zhang, Z., Tachikawa, M., Uchida, Y., & Terasaki, T. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00852 · Cited by 41 · see citing works

Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood–Brain Barrier Model Derived from Hematopoietic Stem Cells

Dehouck, M., Tachikawa, M., Hoshi, Y., Omori, K., Maurage, C., Strecker, G., Dehouck, L., Boucau, M., Uchida, Y., Gosselet, F., et al. (2022) · Cells · doi:10.3390/cells11243963 · Cited by 40 · see citing works

Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

Yusof, S. R., Uzid, M. M., Teh, E., Hanapi, N. A., Mohideen, M., Arshad, A. S. M., Mordi, M. N., Loryan, I., & Hammarlund‐Udenaes, M. (2018) · Addiction Biology · doi:10.1111/adb.12661 · Cited by 40 · see citing works

Utility of Cerebrospinal Fluid Drug Concentration as a Surrogate for Unbound Brain Concentration in Nonhuman Primates

Nagaya, Y., Nozaki, Y., Kobayashi, K., Takenaka, O., Nakatani, Y., Kusano, K., Yoshimura, T., & Kusuhara, H. (2014) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.dmpk-14-rg-026 · Cited by 39 · see citing works

Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers

Masuda, T., Mori, A., Ito, S., & Ohtsuki, S. (2020) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2020.09.006 · Cited by 39 · see citing works

Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway

Rand, D., Ravid, O., Atrakchi, D., Israelov, H., Bresler, Y., Shemesh, C., Omesi, L., Zaltsman, S. L., Gosselet, F., Maskrey, T. S., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030311 · Cited by 39 · see citing works

Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain

Pauwels, M. J., Vandendriessche, C., & Vandenbroucke, R. E. (2021) · Biomedicines · doi:10.3390/biomedicines9111734 · Cited by 37 · see citing works

Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium

Chiba, Y., Murakami, R., Matsumoto, K., Wakamatsu, K., Nonaka, W., Uemura, N., Yanase, K., Kamada, M., & Ueno, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197230 · Cited by 36 · see citing works

Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells

Kurosawa, T., Sako, D., Tega, Y., Debori, Y., Tomihara, Y., Aoyama, K., Kubo, Y., Amano, N., & Deguchi, Y. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03249-3 · Cited by 36 · see citing works

The blood brain barrier: Insights from development and ageing

Delaney, C. P., & Campbell, M. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1373897 · Cited by 35 · see citing works

Study of BBB Dysregulation in Neuropathogenicity Using Integrative Human Model of Blood–Brain Barrier

Gama, C. S. D., & Morin‐Brureau, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.863836 · Cited by 35 · see citing works

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier

Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., & Zhang, J. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00337-9 · Cited by 32 · see citing works

In Vitro Models of CNS Barriers

Abbott, N. J., Dolman, D. E. M., Yusof, S. R., & Reichel, A. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_6 · Cited by 34 · see citing works

Characterization of the Blood–Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

Chaves, C., Declèves, X., Taghi, M., Menet, M., Lacombe, J., Varlet, P., Olaciregui, N. G., Carcaboso, A. M., & Cisternino, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050399 · Cited by 33 · see citing works

TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers

Briggs, K. J., Cottrell, K. M., Tonini, M. R., Tsai, A., Zhang, M., Whittington, D. A., Zhang, W., Lombardo, S. A., Yoda, S., Wilker, E., et al. (2025) · Translational Oncology · doi:10.1016/j.tranon.2024.102264 · Cited by 34 · see citing works

Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats

Brzica, H., Abdullahi, W., Reilly, B. G., & Ronaldson, P. T. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0110-9 · Cited by 33 · see citing works

A Physiologically Based Modeling Strategy during Preclinical CNS Drug Development

Ball, K., Bouzom, F., Scherrmann, J., Walther, B., & Declèves, X. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400533q · Cited by 32 · see citing works

Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases

Gartzke, D., Delzer, J., Laplanche, L., Uchida, Y., Hoshi, Y., Tachikawa, M., Terasaki, T., Sydor, J. R., & Fricker, G. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1599-5 · Cited by 32 · see citing works

Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice

El‐Khateeb, E., Vasilogianni, A., Alrubia, S., Al‐Majdoub, Z. M., Couto, N. A. S., Howard, M., Barber, J., Rostami‐Hodjegan, A., & Achour, B. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107397 · Cited by 32 · see citing works

Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse

Kido, Y., Nanchi, I., Fusamae, Y., Matsuzaki, T., Akazawa, T., Sawada, H., Iwasaki, M., Nishida, K., 土屋栄一, & Okuda, T. (2021) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2021.100426 · Cited by 32 · see citing works

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Badhan, R. K. S., Chenel, M., & Penny, J. I. (2014) · Pharmaceutics · doi:10.3390/pharmaceutics6010097 · Cited by 31 · see citing works

Inner Blood–Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig

Zhang, Z., Uchida, Y., Hirano, S., Ando, D., Kubo, Y., Auriola, S. O. K., Akanuma, S., Hosoya, K., Urtti, A. O., Terasaki, T., et al. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00493 · Cited by 31 · see citing works

Literature review and appraisal on alternative neurotoxicity testing methods

Masjosthusmann, S., Barenys, M., El‐Gamal, M., Geerts, L., Gerosa, L., Gorreja, A., Kühne, B. A., Marchetti, N., Tigges, J., Viviani, B., et al. (2018) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2018.en-1410 · Cited by 31 · see citing works

Developmental changes in transporter and receptor protein expression levels at the rat blood-brain barrier based on quantitative targeted absolute proteomics

Omori, K., Tachikawa, M., Hirose, S., Taii, A., Akanuma, S., Hosoya, K., & Terasaki, T. (2019) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2019.09.003 · Cited by 31 · see citing works

Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios

Sato, S., Matsumiya, K., Tohyama, K., & Kosugi, Y. (2021) · The AAPS Journal · doi:10.1208/s12248-021-00609-6 · Cited by 31 · see citing works

Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain

Sato, S., Liu, S., Goto, A., Yoneyama, T., Okita, K., Yamamoto, S., Hirabayashi, H., Iwasaki, S., & Kusuhara, H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.012 · Cited by 32 · see citing works

The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

Heikkinen, A. T., Lignet, F., Cutler, P., & Parrott, N. J. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400147 · Cited by 30 · see citing works

Mechanistic Study on the Use of the l -Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, E., Gynther, M., de Lange, E. C. M., Auriola, S. O. K., Hammarlund‐Udenaes, M., Huttunen, K. M., & Loryan, I. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00502 · Cited by 30 · see citing works

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Puris, E., Auriola, S. O. K., Petralla, S., Hartman, R., Gynther, M., de Lange, E. C. M., & Fricker, G. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105741 · Cited by 29 · see citing works

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

Dallas, S., Salphati, L., Gomez‐Zepeda, D., Wanek, T., Chen, L.-F., Chu, X., Kunta, J. R., Mezler, M., Menet, M., Chasseigneaux, S., et al. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.102079 · Cited by 29 · see citing works

Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Gustafsson, S. S., Eriksson, J., Syvänen, S., Eriksson, O., Hammarlund‐Udenaes, M., & Antoni, G. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.04.068 · Cited by 29 · see citing works

Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases

Zhang, X., Fu, M., Wang, Y., & Wu, T. S. (2025) · Frontiers in Drug Delivery · doi:10.3389/fddev.2025.1644633 · Cited by 30 · see citing works

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

Murata, Y., Neuhoff, S., Rostami‐Hodjegan, A., Takita, H., Al‐Majdoub, Z. M., & Ogungbenro, K. (2022) · The AAPS Journal · doi:10.1208/s12248-021-00675-w · Cited by 28 · see citing works

Comparison of Absolute Protein Abundances of Transporters and Receptors among Blood–Brain Barriers at Different Cerebral Regions and the Blood–Spinal Cord Barrier in Humans and Rats

Uchida, Y., Yagi, Y., Takao, M., Tano, M., Umetsu, M., Hirano, S., Usui, T., Tachikawa, M., & Terasaki, T. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00178 · Cited by 72 · see citing works

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

Uchida, Y., Ohtsuki, S., Katsukura, Y., Ikeda, C., Suzuki, T., Kamiie, J., & Terasaki, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07208.x · Cited by 881 · see citing works

Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells

Kumabe, H., Masuda, T., Ito, S., Furihata, T., Toda, A., Mogi, M., Araki, N., & Ohtsuki, S. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00650-z · Cited by 16 · see citing works

A human blood–arachnoid barrier atlas of transporters, receptors, enzymes, and tight junction and marker proteins: Comparison with dog and pig in absolute abundance

Uchida, Y., Takeuchi, H., Goto, R., Braun, C., Fuchs, H., Ishiguro, N., Takao, M., Tano, M., & Terasaki, T. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15599 · Cited by 13 · see citing works

Quantitative and Targeted Proteomics of the Blood-Brain Barrier: Species and Cell Line Differences

Ito, S., Masuda, T., & Ohtsuki, S. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_5 · Cited by 1 · see citing works