Pathology and genetics of thyroid carcinoma

DeLellis, Ronald A.

doi:10.1002/jso.20700

Cited by 182Thyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid SurgeryHead and Neck Anomalies

Pathology and genetics of thyroid carcinoma

DeLellis, Ronald A.·2006·Journal of Surgical Oncology

DOI 10.1002/jso.20700

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Abstract

Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive clinical and pathological characteristics. Over the past 15 years, the application of molecular technologies to the study of these neoplasms has elucidated critical genetic pathways associated with the development of specific thyroid tumor types. In papillary thyroid carcinoma (PTC), genetic events involve RET and TRK (rearrangements) and BRAF and RAS (mutations), although RAS mutations are uncommon except in the follicular variant of PTC. These genetic alterations, which rarely overlap in the same tumor, result in signaling abnormalities in the mitogen‐activated protein kinase pathway. In contrast, genetic alterations in follicular carcinomas include PAX8‐PPARγ translocations and RAS mutations while mutations of CTNNB1 and p53 have been implicated in the development and progression of poorly differentiated and undifferentiated (anaplastic) thyroid carcinomas. Germline mutations of RET are responsible for the development of heritable forms of medullary thyroid carcinoma (MTC) while somatic mutations of this oncogene are found in a significant proportion of sporadic MTCs. The results of these studies not only have provided additional approaches to thyroid tumor classification, but also have stimulated the development of novel approaches to tumor diagnosis and additional parameters for prognostic assessment and potential biologic therapeutic strategies. J. Surg. Oncol. 2006;94:662–669. © 2006 Wiley‐Liss, Inc.

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Less than 10% of papillary thyroid carcinomas harbor p53 mutations.
“To date, less than 10% of papillary thyroid carcinomas harbor p53 mutations [27].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [27]
p53 mutations in localized PTC are infrequent.
“In addition, p53 mutations in localized PTC are infrequent [27].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [27]

Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674 · see citing works
Increasing Incidence of Thyroid Cancer in the United States, 1973-2002
Davies, L., & Welch, H. G. (2006) · JAMA · doi:10.1001/jama.295.18.2164 · Cited by 3,379 · see citing works
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
Kimura, E. T., Nikiforova, M. N., Zhu, Z., Knauf, J. A., Nikiforov, Y. E., & Fagin, J. A. (2003) · PubMed · Cited by 1,517 · see citing works
BRAF mutation in thyroid cancer
Xing, M. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.0978 · Cited by 1,300 · see citing works
RAF/RAS oncogenes and mismatch-repair status
Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002) · Nature · doi:10.1038/418934a · Cited by 1,224 · cited 4× · see citing works
“The RAF proteins are serine/threonine protein kinases that play critical roles in cell proliferation, differentiation, and apoptosis by signaling along the mitogen-activated protein kinase pathway (MAPK) [26,27] Mammalian cells express three isoforms of RAF threonine kinase that have been designated ARAF, BRAF, and CR…”
BackgroundInfluential
Pathology and genetics of tumours of endocrine organs
DeLellis, R. A. (2004) · Cited by 1,121 · see citing works
Self-citation
The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
Eng, C. (1996) · JAMA · doi:10.1001/jama.276.19.1575 · Cited by 1,045 · see citing works
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
Nikiforova, M. N., Kimura, E. T., Gandhi, M., Biddinger, P. W., Knauf, J. A., Basolo, F., Zhu, Z., Giannini, R., Salvatore, G., Fusco, A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030838 · Cited by 1,040 · see citing works
BRAF Mutation Predicts a Poorer Clinical Prognosis for Papillary Thyroid Cancer
Xing, M., Westra, W. H., Tufano, R. P., Cohen, Y., Rosenbaum, E., Rhoden, K. J., Carson, K. A., Vasko, V. V., Ларін, О. С., Tallini, G., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0987 · Cited by 991 · see citing works
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
Grieco, M., Santoro, M., Berlingieri, M. T., Melillo, R. M., Donghi, R., Bongarzone, I., Pierotti, M. A., Ports, G. D., Fusco, A., & Vecchiot, G. (1990) · Cell · doi:10.1016/0092-8674(90)90659-3 · Cited by 958 · see citing works
BRAF Mutation in Papillary Thyroid Carcinoma
Cohen, Y., Xing, M., Mambo, E., Guo, Z., Wu, G., Trink, B., Beller, U., Westra, W. H., Ladenson, P. W., & Sidransky, D. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.8.625 · Cited by 918 · see citing works
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Kondo, T., Ezzat, S., & Asa, S. L. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1836 · Cited by 895 · see citing works
Activation of a novel human transforming gene, ret, by DNA rearrangement
Takahashi, M., Ritz, J., & Cooper, G. M. (1985) · Cell · doi:10.1016/0092-8674(85)90115-1 · Cited by 861 · see citing works
The Relationship Between Specific RET Proto-oncogene Mutations and Disease Phenotype in Multiple Endocrine Neoplasia Type 2
Eng, C. (1996) · JAMA · doi:10.1001/jama.1996.03540190047028 · Cited by 822 · see citing works
PAX8-PPAR γ 1 Fusion in Oncogene Human Thyroid Carcinoma
Kroll, T. G., Sarraf, P., Pecciarini, L., Chen, C., Mueller, E., Spiegelman, B. M., & Fletcher, J. A. (2000) · Science · doi:10.1126/science.289.5483.1357 · Cited by 780 · see citing works
RAS Point Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular Carcinoma
Nikiforova, M. N., Lynch, R. A., Biddinger, P. W., Alexander, E. K., Dorn, G. W., Tallini, G., Kroll, T. G., & Nikiforov, Y. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021907 · Cited by 711 · see citing works
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC
Soares, P., Trovisco, V., Rocha, A. S., Lima, J. P., Castro, P., Preto, A., Máximo, V., Botelho, T. O., Seruca, R., & Sobrinho-Simões, M. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206706 · Cited by 676 · see citing works
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
Fagin, J. A., MATSUO, K., Karmakar, A., Chen, D. L., Tang, S., & Koeffler, H. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116168 · Cited by 647 · see citing works
Observer Variation in the Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma
Lloyd, R. V., Erickson, L. A., Casey, M. B., Lam, A. K.-Y., Lohse, C. M., Asa, S. L., Chan, J. K. C., DeLellis, R. A., Harach, H. R., Kakudo, K., et al. (2004) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000135519.34847.f6 · Cited by 499 · see citing works
Self-citation
Correlation Between Genetic Alterations and Microscopic Features, Clinical Manifestations, and Prognostic Characteristics of Thyroid Papillary Carcinomas
Adeniran, A., Zhu, Z., Gandhi, M., Steward, D. L., Fidler, J. P., Giordano, T. J., Biddinger, P. W., & Nikiforov, Y. E. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000176432.73455.1b · Cited by 493 · see citing works
RET/PTC Rearrangement in Thyroid Tumors
Nikiforov, Y. E. (2002) · Endocrine Pathology · doi:10.1385/ep:13:1:03 · Cited by 491 · see citing works
Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human Cells
Nikiforova, M. N., Stringer, J. R., Blough, R. I., Medvedovic, M., Fagin, J. A., & Nikiforov, Y. E. (2000) · Science · doi:10.1126/science.290.5489.138 · Cited by 465 · see citing works
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
Ciampi, R., Knauf, J. A., Kerler, R., Gandhi, M., Zhu, Z., Nikiforova, M. N., Rabes, H. M., Fagin, J. A., & Nikiforov, Y. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23237 · Cited by 459 · see citing works
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.
Xu, X., Quiros, R. M., Gattuso, P., Ain, K. B., & Prinz, R. A. (2003) · PubMed · Cited by 419 · see citing works
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
Knauf, J. A., Ma, X., Smith, E. P., Zhang, L., Mitsutake, N., Liao, X.-H., Refetoff, S., Nikiforov, Y. E., & Fagin, J. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0047 · Cited by 414 · see citing works
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases
Fusco, A., Grieco, M., Santoro, M. M., Berlingieri, M. T., Pilotti, S., Pierotti, M. A., Porta, G., & Vecchio, G. (1987) · Nature · doi:10.1038/328170a0 · Cited by 412 · see citing works
Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.
Donghi, R., Longoni, A., Pilotti, S., Michieli, P., Porta, G., & Pierotti, M. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116385 · Cited by 369 · see citing works
Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications.
Rabes, H. M., Demidchik, E. P., Sidorow, J. D., Lengfelder, E., Beimfohr, C., Hoelzel, D., & Klugbauer, S. (2000) · PubMed · Cited by 367 · see citing works
BRAF mutations are associated with some histological types of papillary thyroid carcinoma
Trovisco, V., de Castro, I. V., Soares, P., Máximo, V., Silva, P., Magalhães, J., AIu, A., Matías‐Guiu, X., & Sobrinho-Simões, M. A. (2004) · The Journal of Pathology · doi:10.1002/path.1511 · Cited by 361 · see citing works
Point Mutations of Ras Oncogenes are an Early Event in Thyroid Tumorigenesis
Namba, H., Rubin, S. A., & Fagin, J. A. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-10-1474 · Cited by 355 · see citing works
PAX8-PPARγ Rearrangement in Thyroid Tumors
Nikiforova, M. N., Biddinger, P. W., Caudill, C. M., Kroll, T. G., & Nikiforov, Y. E. (2002) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200208000-00006 · Cited by 347 · see citing works
Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors
Gimm, O., Perren, A. A., Weng, L., Marsh, D. J., Yeh, J. J., Ziebold, U., Gil, E. B., Hinze, R., Delbridge, L., Lees, J. A., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65040-7 · Cited by 328 · see citing works
Expression of PAX8-PPARγ1 Rearrangements in Both Follicular Thyroid Carcinomas and Adenomas
Marques, A. R., Espadinha, C., Catarino, A. L., Moniz, S., Pereira, T., Sobrinho, L. G., & Leite, V. A. P. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.8.8756 · Cited by 305 · see citing works
BRAF mutations in papillary carcinomas of the thyroid
Fukushima, T., Suzuki, S., Mashiko, M., Ohtake, T., Endo, Y., Takebayashi, Y., Sekikawa, K., Hagiwara, K., & Takenoshita, S. (2003) · Oncogene · doi:10.1038/sj.onc.1206739 · Cited by 297 · see citing works
Pediatric thyroid cancer after the chernobyl disaster. Pathomorphologic study of 84 cases (1991–1992) from the republic of Belarus
Nikiforov, Y. E., & Gnepp, D. R. (1994) · Cancer · doi:10.1002/1097-0142(19940715)74:2 · Cited by 275 · see citing works
Mitochondrial DNA Somatic Mutations (Point Mutations and Large Deletions) and Mitochondrial DNA Variants in Human Thyroid Pathology
Máximo, V., Soares, P., Lima, J. P., Cameselle‐Teijeiro, J., & Sobrinho-Simões, M. A. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61132-7 · Cited by 271 · see citing works
Pain and depression in patients with cancer
Spiegel, D., Sands, S. H., & Koopman, C. (1994) · Cancer · doi:10.1002/1097-0142(19941101)74:9 · Cited by 270 · see citing works
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients’ age but not with tumour aggressiveness
Trovisco, V., Soares, P., Preto, A., de Castro, I. V., Lima, J. P., Castro, P., Máximo, V., Botelho, T. O., Moreira, S., Meireles, A. M., et al. (2005) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-005-1236-0 · Cited by 263 · see citing works
β-Catenin Dysregulation in Thyroid Neoplasms : Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis
García-Rostán, G., Camp, R., Herrero, A., Carcangiu, M., Rimm, D., & Tallini, G. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64045-x · Cited by 257 · see citing works
Genetic Alterations Involved in the Transition from Well-Differentiated to Poorly Differentiated and Anaplastic Thyroid Carcinomas
Nikiforov, Y. E. (2004) · Endocrine Pathology · doi:10.1385/ep:15:4:319 · Cited by 235 · see citing works
Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.
Santoro, M., Chiappetta, G., Cerrato, A., Salvatore, D., Zhang, L., Manzo, G., Picone, A., Portella, G., Santelli, G., Vecchio, G., et al. (1996) · PubMed · Cited by 234 · see citing works
RET Oncogene Activation in Papillary Thyroid Carcinoma
Tallini, G., Asa, S. L., & Fuller, G. N. (2001) · Advances in Anatomic Pathology · doi:10.1097/00125480-200111000-00005 · Cited by 224 · see citing works
Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations
Quiros, R. M., Ding, H. G., Gattuso, P., Prinz, R. A., & Xu, X. (2005) · Cancer · doi:10.1002/cncr.21073 · Cited by 221 · see citing works
Type and Prevalence of BRAF Mutations Are Closely Associated With Papillary Thyroid Carcinoma Histotype and Patients' Age But Not With Tumour Aggressiveness
Fahey, T. J. (2006) · Yearbook of Surgery · doi:10.1016/s0090-3671(08)70420-8 · Cited by 218 · see citing works
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid
Máximo, V., Botelho, T. O., Capela, J., Soares, P., Lima, J. P., Taveira, A., Amaro, T., Barbosa, A. P., Preto, A., Harach, H. R., et al. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602547 · Cited by 213 · see citing works
Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma
Nelson Wohllk, G., Cote, G. J., Bugalho, M. M., Ordoñez, N. G., Evans, D. B., Goepfert, H., Khorana, S., Schultz, P., Richards, C. S., & Gagel, R. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855832 · Cited by 203 · see citing works
Solid Variant of Papillary Thyroid Carcinoma
Nikiforov, Y. E., Erickson, L. A., Nikiforova, M. N., Caudill, C. M., & Lloyd, R. V. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200112000-00002 · Cited by 198 · see citing works
Germline Mutations of the APC Gene in Patients with Familial Adenomatous Polyposis-Associated Thyroid Carcinoma: Results from a European Cooperative Study1
Cetta, F., Montalto, G., Gori, M., Curia, M. C., Cama, A., & Olschwang, S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6254 · Cited by 197 · see citing works
Detection of the PAX8-PPARγ Fusion Oncogene in Both Follicular Thyroid Carcinomas and Adenomas
Cheung, L., Messina, M., Gill, A. J., Clarkson, A., Learoyd, D., Delbridge, L., Wentworth, J. M., Philips, J. N., Clifton-Bligh, R. J., & Robinson, B. G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021020 · Cited by 187 · see citing works
RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features.
Bongarzone, I., Vigneri, P. G., Mariani, L., Collini, P., Pilotti, S., & Pierotti, M. A. (1998) · PubMed · Cited by 178 · see citing works
Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma?
Cameselle‐Teijeiro, J., & Chan, J. K. C. (1999) · PubMed · Cited by 176 · see citing works
Germline Mutations of the APC Gene in Patients with Familial Adenomatous Polyposis-Associated Thyroid Carcinoma: Results from a European Cooperative Study
Cetta, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.1.286 · Cited by 159 · see citing works
Papillary Thyroid Carcinoma Oncogene (RET/PTC) Alters the Nuclear Envelope and Chromatin Structure
Fischer, A. H., BOND, J. A., Taysavang, P., Battles, O. E., & Wynford‐Thomas, D. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65731-8 · Cited by 130 · see citing works
Molecular Basis of Hurthle Cell Papillary Thyroid Carcinoma1
Cheung, C. C., Ezzat, S., Ramyar, L., Freeman, J. L., & Asa, S. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6404 · Cited by 130 · see citing works
BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas
Soares, P., Trovisco, V., Rocha, A. S., Feij�o, T., Rebocho, A. P., Fonseca, E., de Castro, I. V., Cameselle‐Teijeiro, J., Cardoso-Oliveira, M., & Sobrinho-Sim�es, M. (2004) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-004-1018-0 · Cited by 124 · see citing works
Alterations of the BRAF Gene in Thyroid Tumors
Ciampi, R., & Nikiforov, Y. E. (2005) · Endocrine Pathology · doi:10.1385/ep:16:3:163 · Cited by 117 · see citing works
Expression of PAX8-PPAR 1 Rearrangements in Both Follicular Thyroid Carcinomas and Adenomas
Marques, A. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.8.3947 · Cited by 110 · see citing works
Occult micropapillary carcinoma associated with benign follicular thyroid disease and unrelated thyroid neoplasms.
Fink, A. K., TOMLINSON, G. A., Freeman, J. L., Rosen, I. B., & Asa, S. L. (1996) · PubMed · Cited by 109 · see citing works
Paucicellular Variant of Anaplastic Thyroid Carcinoma:A Mimic of Riedel's Thyroiditis
Wan, S.-K., Chan, J., & Tang, S.-K. (1996) · American Journal of Clinical Pathology · doi:10.1093/ajcp/105.4.388 · Cited by 106 · see citing works
Loss of p53 Promotes Anaplasia and Local Invasion in ret/PTC1-Induced Thyroid Carcinomas
Perle, K. M. D. L., Jhiang, S. M., & Capen, C. C. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64577-4 · Cited by 105 · see citing works
Molecular genetic study comparing follicular variant versus classic papillary thyroid carcinomas: association of N-ras mutation in codon 61 with follicular variant
Cristofaro, J. D., Marcy, M., Vasko, V. V., Sebag, F. A., Fakhry, N., Wynford‐Thomas, D., & Micco, C. D. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.01.030 · Cited by 102 · see citing works
B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas
Trovisco, V., Soares, P., & Sobrinho-Simões, M. A. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.03.013 · Cited by 81 · see citing works
Molecular pathology of well-differentiated thyroid carcinomas
Sobrinho-Simões, M. A., Preto, A., Rocha, A. S., Castro, P., Máximo, V., Fonseca, E., & Soares, P. (2005) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-005-0065-5 · Cited by 78 · see citing works
Hürthle (Oncocytic) Cell Tumors of Thyroid: Etiopathogenesis, Diagnosis and Clinical Significance
Sobrinho-Simões, M. A., Máximo, V., de Castro, I. V., Fonseca, E., Soares, P., García‐Rostán, G., & de Oliveira, M. C. (2005) · International Journal of Surgical Pathology · doi:10.1177/106689690501300104 · Cited by 70 · see citing works
Implication of vascular endothelial growth factor and p53 status for angiogenesis in noninvasive colorectal carcinoma
Kondo, Y., Arii, S., Furutani, M., Isigami, S., Mori, A., Onodera, H., Chiba, T., & Imamura, M. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000415)88:8 · Cited by 69 · see citing works
Mutations of p53 in Thyroid Carcinoma with an Insular Component
Takeuchi, Y., Daa, T., Kashima, K., Yokoyama, S., Nakayama, I., & Noguchi, S. (1999) · Thyroid · doi:10.1089/thy.1999.9.377 · Cited by 68 · see citing works
Molecular Basis of Hurthle Cell Papillary Thyroid Carcinoma
Cheung, C. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.878 · Cited by 68 · see citing works
Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.
Kawai, K., Iwashita, T., Murakami, H., Hiraiwa, N., Yoshiki, A., Kusakabe, M., Ono, K., Iida, K.-I., Nakayama, A., & Takahashi, M. (2000) · PubMed · Cited by 66 · see citing works
Ras Oncogene Mutations in Thyroid Tumors
Capellá, G., Matías‐Guiu, X., Ampudia, X., de Leiva, A., Perucho, M., & Prat, J. (1996) · Diagnostic Molecular Pathology · doi:10.1097/00019606-199603000-00008 · Cited by 66 · see citing works
DNA ploidy pattern in human chronic liver diseases and hepatic nodular lesions. Flow cytometric analysis on echo‐guided needle liver biopsy
Anti, M., Marra, G., Rapaccini, G., Rumi, C., Bussa, S., Fadda, G., Vecchio, F., Valenti, A., Percesepe, A., Pompili, M., et al. (1994) · Cancer · doi:10.1002/1097-0142(19940115)73:2 · Cited by 50 · see citing works
Deletion of 3p25→pter in a primary follicular thyroid carcinoma and its metastasis
Roque, L., Castedo, S. M. M. J., Clode, A. L., & Soares, J. (1993) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870080311 · Cited by 45 · see citing works
Lymphoepithelioma-like carcinoma of the thyroid gland: Lack of evidence of association with Epstein-Barr virus
Shek, T. W. H., Luk, I. S. C., Ng, I. O., & Lo, C. Y. (1996) · Human Pathology · doi:10.1016/s0046-8177(96)90461-x · Cited by 42 · see citing works
A t(2;3)(q12–13;p24–25) in follicular thyroid adenomas
Sozzi, G., Miozzo, M. R., Cariani, T., Bongarzone, I., Pilotti, S., Pierotti, M. A., & Porta, G. (1992) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(92)90320-8 · Cited by 39 · see citing works
Genetic Considerations in Thyroid Cancer
Patel, K. N., & Singh, B. (2006) · Cancer Control · doi:10.1177/107327480601300205 · Cited by 33 · see citing works
Understanding the Genotype of Follicular Thyroid Tumors
Hunt, J. L. (2005) · Endocrine Pathology · doi:10.1385/ep:16:4:311 · Cited by 28 · see citing works
TRK Oncogenes in Papillary Thyroid Carcinoma
Greco, A., Roccato, E., & Pierotti, M. A. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-8107-3_12 · Cited by 25 · see citing works

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Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)
Thakker, R. V., Newey, P. J., Walls, G. V., Bilezikian, J. P., Dralle, H., Ebeling, P. R., Melmed, S. K., Sakurai, A., Tonelli, F., & Brandi, M. L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1230 · Cited by 1,473 · see citing works
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis, G. L., Waguespack, S. G., Bauer, A. J., Angelos, P., Benvenga, S., Cerutti, J. M., Dinauer, C., Hamilton, J. K., HAY, I. D., Luster, M., et al. (2015) · Thyroid · doi:10.1089/thy.2014.0460 · Cited by 1,252 · see citing works
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Burkhart, D. L., & Sage, J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2399 · Cited by 974 · see citing works
Motesanib Diphosphate in Progressive Differentiated Thyroid Cancer
Sherman, S. I., Wirth, L. J., Droz, J.-P., Hofmann, M., Bastholt, L., Martins, R. G., Licitra, L., Eschenberg, M. J., Sun, Y.-N., Juan, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075853 · Cited by 470 · see citing works
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
Guðmundsson, J., Sulem, P., Gudbjartsson, D. F., Jonasson, J. G., Sigurðsson, Á., Bergþorsson, J. Þ., He, H., Blöndal, T., Geller, F., Jakobsdottir, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.339 · Cited by 393 · see citing works
Discovery of common variants associated with low TSH levels and thyroid cancer risk
Guðmundsson, J., Sulem, P., Gudbjartsson, D. F., Jonasson, J. G., Másson, G., He, H., Jónasdóttir, Á., Sigurðsson, Á., Stacey, S., Johannsdottir, H., et al. (2012) · Nature Genetics · doi:10.1038/ng.1046 · Cited by 246 · see citing works
Genomic Dissection of Hurthle Cell Carcinoma Reveals a Unique Class of Thyroid Malignancy
Ganly, I., Ricarte‐Filho, J. C., Eng, S., Ghossein, R. A., Morris, L. G. T., Liang, Y., Socci, N. D., Kannan, K. S., Mo, Q., Fagin, J. A., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3539 · Cited by 220 · see citing works
A genome-wide association study yields five novel thyroid cancer risk loci
Guðmundsson, J., Þorleifsson, G., Sigurdsson, J. K., Stefánsdóttir, L., Jonasson, J. G., Gudjonsson, S. A., Gudbjartsson, D. F., Másson, G., Johannsdottir, H., Halldorsson, G. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14517 · Cited by 158 · see citing works
Prognostic implication of BRAF and TERT promoter mutation combination in papillary thyroid carcinoma—A meta‐analysis
Vuong, H. G., Altibi, A. M. A., Duong, U. N. P., & Hassell, L. A. (2017) · Clinical Endocrinology · doi:10.1111/cen.13413 · Cited by 144 · see citing works
Genome-Wide Association Study on Differentiated Thyroid Cancer
Köhler, A., Chen, B., Gemignani, F., Elisei, R., Romei, C., Figlioli, G., Cipollini, M., Cristaudo, A., Bambi, F., Hoffmann, P., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1941 · Cited by 142 · see citing works
The Associations Between RAS Mutations and Clinical Characteristics in Follicular Thyroid Tumors: New Insights from a Single Center and a Large Patient Cohort
Fukahori, M., Yoshida, A., Hayashi, H., Yoshihara, M., Matsukuma, S., Sakuma, Y., Koizume, S., Okamoto, N., Kondo, T., Masuda, M., et al. (2012) · Thyroid · doi:10.1089/thy.2011.0261 · Cited by 137 · see citing works
Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
Chan, K. T., Li, K., Liu, S. L., Chu, K. H., Toh, M., & Xie, W. D. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.07.015 · Cited by 136 · see citing works
Clinicopathological and molecular characterization of nine cases of columnar cell variant of papillary thyroid carcinoma
Chen, J.-H., Faquin, W. C., Lloyd, R. V., & Nosé, V. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.2 · Cited by 129 · see citing works
Thyroid Pathology in PTEN -Hamartoma Tumor Syndrome: Characteristic Findings of a Distinct Entity
Laury, A. R., Bongiovanni, M., Tille, J., Kozakewich, H. P., & Nosé, V. (2010) · Thyroid · doi:10.1089/thy.2010.0226 · Cited by 108 · see citing works
The Heterogeneous Distribution of BRAF Mutation Supports the Independent Clonal Origin of Distinct Tumor Foci in Multifocal Papillary Thyroid Carcinoma
Giannini, R., Ugolini, C., Lupi, C., Proietti, A., Elisei, R., Salvatore, G., Berti, P., Materazzi, G., Miccoli, P., Santoro, M., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0594 · Cited by 108 · see citing works
Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns
Eszlinger, M., & Paschke, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.010 · Cited by 104 · see citing works
Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice
Tirrò, E., Martorana, F., Romano, C., Vitale, S. R., Motta, G., Gregorio, S. D., Massimino, M., Pennisi, M. S., Stella, S., Puma, A., et al. (2019) · Genes · doi:10.3390/genes10090709 · Cited by 101 · see citing works
Synthesis, Characterization, and in Vivo Delivery of siRNA-Squalene Nanoparticles Targeting Fusion Oncogene in Papillary Thyroid Carcinoma
Raouane, M., Desmaële, D., Gilbert-Sirieix, M., Gueutin, C., Zouhiri, F., Bourgaux, C., Lepeltier, É., Gref, R., Salah, R. B., Clayman, G. L., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2000272 · Cited by 93 · see citing works
Molecular techniques in cytopathology practice
Schmitt, F. C., Longatto‐Filho, A., Valent, A., & Vielh, P. R. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2006.044347 · Cited by 92 · see citing works
Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study
Rivera, M., Ricarte‐Filho, J. C., Patel, S. G., Tuttle, M. R., Shaha, A. R., Shah, J. P., Fagin, J. A., & Ghossein, R. A. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.08.011 · Cited by 90 · see citing works
Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer
Son, H., Hwangbo, Y., Yoo, S., Im, S.-W., Yang, S., Kwak, S.-J., Park, M. S., Kwak, S. H., Cho, S. W., Ryu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15966 · Cited by 86 · see citing works
Familial Non-Medullary Thyroid Carcinoma: An Update
Nosé, V. (2008) · Endocrine Pathology · doi:10.1007/s12022-008-9045-z · Cited by 81 · see citing works
Histopathologic and Clinical Features of Medullary Microcarcinoma and C-Cell Hyperplasia in Prophylactic Thyroidectomies for Medullary Carcinoma: A Study of 42 Cases
Etıt, D., Faquin, W. C., Gaz, R. D., Randolph, G. W., DeLellis, R. A., & Pilch, B. Z. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/132.11.1767 · Cited by 68 · see citing works
Self-citation
Inhibitory Effects of the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 on the Proliferation and Tumor Growth of Thyroid Cancer Cells withBRAForRASMutations
Liu, D., Liu, Z., JIANG, D., Dackiw, A. P. B., & Xing, M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0097 · Cited by 67 · see citing works
Familial Thyroid Carcinoma
Dotto, J., & Nosé, V. (2008) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e31818a64af · Cited by 62 · see citing works
Clonal analysis of bilateral, recurrent, and metastatic papillary thyroid carcinomas
Wang, W., Wang, H., Teng, X., Wang, H., Mao, C., Teng, R., Zhao, W., Cao, J., Fahey, T. J., & Teng, L. (2010) · Human Pathology · doi:10.1016/j.humpath.2010.02.008 · Cited by 62 · see citing works
Mitochondria and cancer
Máximo, V., Lima, J. P., Soares, P., & Sobrinho-Simões, M. A. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0766-2 · Cited by 58 · see citing works
siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
de Martimprey, H., Bertrand, J., Fusco, A., Santoro, M. M., Couvreur, P., Vauthier, C., & Malvy, C. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn882 · Cited by 59 · see citing works
siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
de Martimprey, H., Bertrand, J., Fusco, A., Santoro, M. M., Couvreur, P., Vauthier, C., & Malvy, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1094 · Cited by 58 · see citing works
Thyroid Cancer of Follicular Cell Origin in Inherited Tumor Syndromes
Nosé, V. (2010) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3181f8b028 · Cited by 55 · see citing works
Expression of Hypoxia-Associated Protein HIF-1α in Follicular Thyroid Cancer is Associated with Distant Metastasis
Aumayr, K., Fathi, O., Traub‐Weidinger, T., Niederle, B., & Koperek, O. (2017) · Pathology & Oncology Research · doi:10.1007/s12253-017-0232-4 · Cited by 54 · see citing works
Decreased 1-25 Dihydroxyvitamin D3 Concentration in Peripheral Blood Serum of Patients with Thyroid Cancer
Stępień, T., Krupiński, R., Sopiński, J., Kuzdak, K., Komorowski, J., Ławnicka, H., & Stepien, H. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.04.004 · Cited by 54 · see citing works
Advances and challenges in thyroid cancer: The interplay of genetic modulators, targeted therapies, and AI-driven approaches.
Bhattacharya, S., Mahato, R. K., Singh, S., Bhatti, G. K., Mastana, S., & Bhatti, J. S. (2023) · Life Science · doi:10.1016/j.lfs.2023.122110 · Cited by 48 · see citing works
Micro-RNAs in thyroid neoplasms: molecular, diagnostic and therapeutic implications
Menon, M. P., & Khan, A. A. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.063909 · Cited by 51 · see citing works
Platelet‐derived growth factor receptor‐α promotes lymphatic metastases in papillary thyroid cancer
Zhang, J., Wang, P., Dykstra, M. A., Gélébart, P., Williams, D., Ingham, R. J., Adewuyi, E. E., Lai, R. L., & McMullen, T. P. W. (2012) · The Journal of Pathology · doi:10.1002/path.4069 · Cited by 51 · see citing works
Medullary thyroid carcinoma: The third most common thyroid cancer reviewed
Stamatakos, M., Paraskeva, P., Stefanaki, C., Katsaronis, P., Lazaris, A. C., Safioleas, K., & Kontzoglou, K. (2010) · Oncology Letters · doi:10.3892/ol.2010.223 · Cited by 46 · see citing works
The Emerging Role of Insulin Receptor Isoforms in Thyroid Cancer: Clinical Implications and New Perspectives
Vella, V., & Malaguarnera, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123814 · Cited by 45 · see citing works
Diagnostic and prognostic implications of the PAX 8– PPAR γ translocation in thyroid carcinomas—a TMA ‐based study of 226 cases
Boos, L. A., Dettmer, M. S., Schmitt, A. M., Rudolph, T. J., Steinert, H. C., Moch, H., Sobrinho-Simões, M. A., Komminoth, P., & Perren, A. A. (2013) · Histopathology · doi:10.1111/his.12150 · Cited by 44 · see citing works
Occult thyroid carcinoma.
Bouček, J., Kastner, J., Skrivan, J., Grosso, E., Gibelli, B., Giugliano, G., & Betka, J. (2009) · PubMed Central · Cited by 43 · see citing works
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples
Ribeiro, F. R., Meireles, A. M., Rocha, A. S., & Teixeira, M. R. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-371 · Cited by 41 · see citing works
Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
Dodurga, Y., Güneş, C. E., Seçme, M., Elmas, L., Avcı, Ç. B., & Şatıroğlu-Tufan, N. L. (2015) · Tumor Biology · doi:10.1007/s13277-015-3984-z · Cited by 40 · see citing works
FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1
Morillo-Bernal, J., Fernández, L. P., & Santisteban, P. (2020) · Endocrine Related Cancer · doi:10.1530/erc-19-0156 · Cited by 40 · see citing works
Thyroid Cancer and Circadian Clock Disruption
Malaguarnera, R., Ledda, C., Filippello, A., Frasca, F., Francavilla, V. C., Ramaci, T., Parisi, M. C., Rapisarda, V., & Piro, S. (2020) · Cancers · doi:10.3390/cancers12113109 · Cited by 40 · see citing works
Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer
Zheng, J., Li, C., Lu, W., Wang, C., & Ai, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.9201 · Cited by 38 · see citing works
Molecular genetics of papillary thyroid carcinoma: great expectations...
Trovisco, V., Soares, P., Preto, A., Castro, P., Máximo, V., & Sobrinho-Simões, M. A. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000500002 · Cited by 37 · see citing works
Patterns of FOXE1 Expression in Papillary Thyroid Carcinoma by Immunohistochemistry
Bychkov, A., Saenko, V., Nakashima, M., Mitsutake, N., Rogounovitch, T., Nikitski, A. V., Orim, F., & Yamashita, S. (2013) · Thyroid · doi:10.1089/thy.2012.0466 · Cited by 37 · see citing works
Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma
Enríquez, J. E., Muñoz-Montero, S. A., Imaz-Rosshandler, I., Huerta-Verde, A. J., Mejía, C., & Lemus, E. H. (2015) · BMC Genomics · doi:10.1186/s12864-015-1372-0 · Cited by 35 · see citing works
Update on Recent Developments in the Therapy of Differentiated Thyroid Cancer
Middendorp, M., & Grünwald, F. (2010) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2009.10.006 · Cited by 34 · see citing works
Molecular signatures of thyroid follicular neoplasia
Borup, R., Rossing, M., Henao, R., Yamamoto, Y., Krogdahl, A., Godballe, C., Winther, O., Kiss, K., Christensen, L. H., Høgdall, E. V. S., et al. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0288 · Cited by 31 · see citing works
Pathology of Thyroid Gland
Khan, A. A., & Nosé, V. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1069-1_9 · Cited by 31 · see citing works
Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells
Chen, H., Luo, D., Zhang, L., Lin, X., Luo, Q., Yi, H., Wang, J., Yan, X., Li, B., Chen, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17398 · Cited by 29 · see citing works
A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma
Figlioli, G., Elisei, R., Romei, C., Melaiu, O., Cipollini, M., Bambi, F., Chen, B., Köhler, A., Cristaudo, A., Hemminki, K., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0652 · Cited by 29 · see citing works
Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma
Khatami, F., Larijani, B. A., Heshmat, R., Nasiri, S., Aghdam, M. H., Teimoori‐Toolabi, L., & Tavangar, S. M. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29591 · Cited by 29 · see citing works
Upregulation of the signal transducers and activators of transcription 3 (STAT3) pathway in lymphatic metastases of papillary thyroid cancer.
Zhang, J., Gill, A. J., Atmore, B. B., Johns, A. L., Delbridge, L., Lai, R. L., & McMullen, T. P. W. (2011) · PubMed Central · Cited by 29 · see citing works
A Brief Review on The Molecular Basis of Medullary Thyroid Carcinoma.
Mohammadi, M., & Hedayati, M. (2017) · PubMed Central · doi:10.22074/cellj.2016.4715 · Cited by 29 · see citing works
Anaplastic thyroid cancer, tumorigenesis and therapy
O'Neill, J. P., Power, D., Condron, C. M., Bouchier‐Hayes, D., & Walsh, M. (2009) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-009-0364-y · Cited by 28 · see citing works
Immunohistochemical Expression of HBME-1, E-cadherin, and CD56 in the Differential Diagnosis of Thyroid Nodules
Ozoliņš, A., Narbuts, Z., Štrumfa, I., Volanska, G., Stepanovs, K., & Gardovskis, J. (2012) · Medicina · doi:10.3390/medicina48100074 · Cited by 27 · see citing works
Surgical management of thyroid cancer
Ramírez, A., Gibelli, B., Tradati, N., Giugliano, G., Zurlo, V., Grosso, E., & Chiesa, F. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.9.1203 · Cited by 27 · see citing works
Diagnostic utility of immunohistochemical panel in various thyroid pathologies
Ozoliņš, A., Narbuts, Z., Štrumfa, I., Volanska, G., & Gardovskis, J. (2010) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-010-0690-6 · Cited by 26 · see citing works
VE1 immunohistochemical detection of the BRAF V600E mutation in thyroid carcinoma: a review of its usefulness and limitations
Na, J., Kim, J., Kim, H.-J., Kim, H.-K., Moon, K., Lee, J. S., Lee, J.-H., Lee, K., & Park, J. (2015) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-015-1773-0 · Cited by 25 · see citing works
Analysis of RAS mutation and PAX8/PPARγ rearrangements in follicular-derived thyroid neoplasms in a Korean population: frequency and ultrasound findings
Jeong, S. H., Hong, H. S., Kwak, J. J., & Lee, E. H. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0311-x · Cited by 25 · see citing works
Hypoparathyroidism in Pregnancy and Lactation: Current Approach to Diagnosis and Management
Ali, D. S., Dandurand, K., & Khan, A. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071378 · Cited by 24 · see citing works
Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling
Aherne, S. T., Smyth, P. C., Flavin, R., Russell, S. M., Denning, K. M., Li, J. H., Guenther, S. M., O’Leary, J. J., & Sheils, O. M. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-89 · Cited by 24 · see citing works
Restoration of Brain Acid Soluble Protein 1 Inhibits Proliferation and Migration of Thyroid Cancer Cells
Guo, R.-S., Yu, Y., Chen, J., Chen, Y., Shen, N., & Qiu, M. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.183434 · Cited by 24 · see citing works
Immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions
He, X., Wei, Q., Zhang, X., Xiao, J., Jin, X., Zhu, Y., Cui, B., & Ning, G. (2010) · Pathology - Research and Practice · doi:10.1016/j.prp.2010.05.003 · Cited by 24 · see citing works
BRAFV600E status and clinical characteristics in solitary and multiple papillary thyroid carcinoma: experience of 512 cases at a clinical center in China
Zheng, X., Xia, T., Lin, L., Gao, S., Lee, Y., Yu, Y., Wei, S., & Gao, M. (2012) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-10-104 · Cited by 24 · see citing works
Secretome proteins as candidate biomarkers for aggressive thyroid carcinomas
Chaker, S., Kashat, L., Voisin, S. N., Kaur, J., Kak, I., MacMillan, C., Özçelik, H., Siu, K. W. M., Ralhan, R., & Walfish, P. G. (2013) · PROTEOMICS · doi:10.1002/pmic.201200356 · Cited by 23 · see citing works
Surgical management of follicular thyroid carcinoma in children and adolescents: A study of 30 cases
Spinelli, C., Rallo, L., Morganti, R., Mazzotti, V., Inserra, A., Cecchetto, G., Massimino, M., Collini, P., & Strambi, S. (2018) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2018.05.017 · Cited by 23 · see citing works
Papillary carcinoma of the breast lacks evidence of RET rearrangements despite morphological similarities to papillary thyroid carcinoma
Hameed, O., Perry, A., Banerjee, R., Zhu, X., & Pfeifer, J. D. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.91 · Cited by 23 · see citing works
Differentiated thyroid cancers: a comprehensive review of novel targeted therapies
Kojic, K. L., Kojic, S. L., & Wiseman, S. M. (2012) · Expert Review of Anticancer Therapy · doi:10.1586/era.12.8 · Cited by 23 · see citing works
Association between Decreased WWOX Protein Expression and Thyroid Cancer Development
Dias, E. P., Pimenta, F. J., Sarquis, M., Filho, M. A. D., Aldaz, C. M., Fujii, J. B., Gomez, R. S., & Marco, L. A. D. (2007) · Thyroid · doi:10.1089/thy.2007.0232 · Cited by 23 · see citing works
Surgical Management of Familial Papillary Thyroid Microcarcinoma: A Single Institution Study of 94 Cases
Sung, T., Lee, Y., Yoon, J. H., Chung, K., & Hong, S. J. (2015) · World Journal of Surgery · doi:10.1007/s00268-015-3064-y · Cited by 22 · see citing works
Immunohistology of Endocrine Tumors
DeLellis, R. A., & Shin, S. J. (2006) · Elsevier eBooks · doi:10.1016/b978-0-443-06652-8.50015-6 · Cited by 22 · see citing works
Self-citation
RET Gene Abnormalities and Thyroid Disease: Who Should be Screened and When
Salehian, B., & Samoa, R. A. (2013) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.870 · Cited by 21 · see citing works
Differential Expression of a Set of Genes in Follicular and Classic Variants of Papillary Thyroid Carcinoma
İğci, Y. Z., Arslan, A., Akarsu, E., Erkılıç, S., İğci, M., Öztuzcu, S., Cengiz, B., Göğebakan, B., Çakmak, E. A., & Demiryürek, A. T. (2011) · Endocrine Pathology · doi:10.1007/s12022-011-9157-8 · Cited by 21 · see citing works
The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma
Yang, X., Hu, Y., Shi, H., Zhang, C., Wang, Z., Liu, X., Chen, H., Zhang, L., & Cui, D. (2018) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-018-5045-x · Cited by 21 · see citing works
Utility of immunohistochemical markers in differential diagnosis of follicular cell-derived thyroid lesions
Alshenawy, H. A. (2014) · Journal of Microscopy and Ultrastructure · doi:10.1016/j.jmau.2014.02.004 · Cited by 19 · see citing works
Utility of Immunohistochemical Markers in Diagnosis of Follicular Cell Derived Thyroid Lesions
Alshenawy, H. A. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-014-9760-3 · Cited by 19 · see citing works
Clinical Impact of Molecular Analysis on Thyroid Cancer Management
Wreesmann, V. B., & Singh, B. (2008) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2007.10.013 · Cited by 19 · see citing works
Anaplastic thyroid cancer: How far can we go?
Amaral, M., Afonso, R. A., Gaspar, M. M., & Reis, C. P. (2020) · EXCLI journal · doi:10.17179/excli2020-2257 · Cited by 18 · see citing works
Review of the genetics of thyroid tumours: diagnostic and prognostic implications
Gilfillan, C. P. (2010) · ANZ Journal of Surgery · doi:10.1111/j.1445-2197.2009.05173.x · Cited by 18 · see citing works
Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas
Faria, M., Capinha, L., Simões‐Pereira, J., Bugalho, M. J., & Silva, A. L. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1972367 · Cited by 16 · see citing works
Clusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?
Fuzio, P., Napoli, A., Ciampolillo, A., Lattarulo, S., Pezzolla, A., Nuzziello, N., Liuni, S., Giorgino, F., Maiorano, E., & Perlino, E. (2015) · BMC Cancer · doi:10.1186/s12885-015-1348-0 · Cited by 16 · see citing works
Pathology and Cytologic Features of Thyroid Neoplasms
Malloy, K. M., & Cunnane, M. F. (2008) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2007.10.012 · Cited by 16 · see citing works
Suppressed Krüppel-like factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma
YE, W.-C., GAO, L., Huang, J., FANG, X.-M., & ., G. X. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2429 · Cited by 15 · see citing works
Thyroid Cancer in Pediatrics
Macháč, J. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.02.002 · Cited by 15 · see citing works
Molecular Alterations in Hereditary and Sporadic Thyroid and Parathyroid Diseases
Hunt, J. L. (2008) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3181915f7d · Cited by 15 · see citing works
The Adolescent and Young Adult With Cancer: State of the Art—Epithelial Cancer
Ferreira, C. G., de Melo, A. C., & Nogueira‐Rodrigues, A. (2013) · Current Oncology Reports · doi:10.1007/s11912-013-0322-8 · Cited by 15 · see citing works
Genetic basis and gene therapy trials for thyroid cancer.
Al‐Humadi, H., Zarros, A. C., Al‐Saigh, R., & Liapi, C. A. (2010) · PubMed · Cited by 15 · see citing works
Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer
Li, X., Wen, R., Wen, D., Lin, P., Pan, D., Zhang, L., He, Y., Shi, L., Qin, Y., Lai, Y., et al. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11310 · Cited by 14 · see citing works
Associations between rs965513/rs944289 and papillary thyroid carcinoma risk: a meta-analysis
Ai, L., Liu, X., Yao, Y., Yu, Y., Sun, H., & Yu, Q. (2014) · Endocrine · doi:10.1007/s12020-014-0256-4 · Cited by 14 · see citing works
Therapeutic potential of nuclear receptors
Schweitzer, A., Knauer, S. K., & Stauber, R. H. (2008) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.18.8.861 · Cited by 14 · see citing works
Immunohistology of Endocrine Tumors
DeLellis, R. A., Shin, S. J., & Treaba, D. O. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5766-6.00014-5 · Cited by 14 · see citing works
Self-citation
Differentiation of the Follicular Variant of Papillary Thyroid Carcinoma From Classic Papillary Thyroid Carcinoma: An Ultrasound Analysis and Complement to Fine‐Needle Aspiration Cytology
Ng, S., Kuo, S., Hua, C., Huang, B., Chiang, K., Chu, Y., Hsueh, C., & Lin, J. (2017) · Journal of Ultrasound in Medicine · doi:10.1002/jum.14377 · Cited by 13 · see citing works
Activated Leukocyte Cell Adhesion Molecule Is a Marker for Thyroid Carcinoma Aggressiveness and Disease-Free Survival
Chaker, S., Kak, I., MacMillan, C., Ralhan, R., & Walfish, P. G. (2012) · Thyroid · doi:10.1089/thy.2012.0405 · Cited by 12 · see citing works
Prevalence and Risk of Metastatic Thyroid Cancers and Management Outcomes: A National Perspective
Al‐Qurayshi, Z., Sullivan, C. B., Pagedar, N. A., Lee, G. S., Tufano, R. P., & Kandil, E. H. (2020) · The Laryngoscope · doi:10.1002/lary.28722 · Cited by 12 · see citing works
Pattern of Thyroid Cancer in the Eastern Province of Saudi Arabia: University Hospital Experience
Al-Amri, A. M. (2012) · Journal of Cancer Therapy · doi:10.4236/jct.2012.33027 · Cited by 11 · see citing works
Expression of the PAX8/PPAR Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis
Reddi, H. V., Madde, P., Marlow, L. A., Copland, J. A., McIver, B., Grebe, S. K., & Eberhardt, N. L. (2010) · Genes & Cancer · doi:10.1177/1947601910373545 · Cited by 11 · see citing works
Clinicopathological characterization and prognostic implication of FOXP3 and CK19 expression in papillary thyroid carcinoma and concomitant Hashimoto's thyroiditis
Mohamed, S. Y., Ibrahim, T. R., Elbasateeny, S. S., Abdelaziz, L. A., Farouk, S., Yassin, M. A., & Embaby, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-67615-0 · Cited by 11 · see citing works
The pituitary tumor transforming gene in thyroid cancer.
Lewy, G. D., Sharma, N., Seed, R., Smith, V. E., Boelaert, K., & McCabe, C. J. (2012) · PubMed · doi:10.3275/8332 · Cited by 10 · see citing works

Authors: DeLellis, R. A.
Affiliations: Brown University (US)
Corresponding author: DeLellis, Ronald A.
ORCID: DeLellis, Ronald A.
Venue: Journal of Surgical Oncology
Publisher: Wiley
Published: 2006-11-27
Volume: 94
Issue: 8
Pages: 662-669
ISSN: 0022-4790 (ISSN-L)
1096-9098
DOI: 10.1002/jso.20700
OpenAlex: W1508880004
Cited by: 181
References: 76
Citations by year: 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 7 · 2013: 13 · 2012: 20
FWCI: 8.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Surgical Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Surgery › Head and Neck Anomalies
Keywords: thyroid cancer, papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma, RET fusion, BRAF mutation, RAS mutations, CTNNB1 mutation, TP53 mutation, anaplastic thyroid carcinoma, familial medullary thyroid carcinoma, RET germline mutation, MAPK signaling, prognostic assessment, molecular diagnosis
MeSH terms: Adenocarcinoma, Papillary, Carcinoma, Humans, Molecular Biology, Mutation, Multiple Endocrine Neoplasia, Genes, ras, Thyroid Neoplasms, Point Mutation, Adenoma, Oxyphilic, Adenocarcinoma, Follicular, Receptor, trkA, Proto-Oncogene Proteins B-raf, PTEN Phosphohydrolase, Proto-Oncogene Proteins c-ret

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