Cited by 94Cancer Immunotherapy and BiomarkersT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer

Saito, Hiroaki, Kuroda, Hirohiko, Matsunaga, Tomoyuki, Osaki, Tomohiro, Ikeguchi, Masahide·2013·Journal of Surgical Oncology

Abstract

BACKGROUND: Co-signaling molecules play an important role in T cells. Programmed death-1 (PD-1) is an immunoinhibitory receptor and its overexpression on T cells appears to be involved in immune evasion in cancer patients. The present study was designed to investigate PD-1 expression on T cells and its relationship with immune evasion in gastric cancer patients. METHODS: PD-1 expression on CD4+ and CD8+ T cells obtained from peripheral blood mononuclear cells (PBMC), normal gastric mucosa, and gastric cancer tissue was evaluated by multicolor flow cytometry. RESULTS: PD-1 expression on CD4+ and CD8+ T cells from gastric cancer patients was significantly higher than that from normal controls. PD-1 expression on CD4+ and CD8+ T cells was related to disease progression. Furthermore, PD-1 expression on CD4+ and CD8+ T cells from gastric cancer tissue was significantly higher than that from normal gastric mucosa and PBMC. PD-1 positive CD4+ and CD8+ T cells produced significantly less IFN-gamma than PD-1 negative CD4+ and CD8+ T cells. CONCLUSIONS: Upregulation of PD-1 on both CD4+ and CD8+ T cells may be, in part, responsible for immune evasion in gastric cancer patients.

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Crossref · 10.1002/jso.23281

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  • Blocking antibodies targeting PD-1 signaling mainly affect the effector stage of the immune response.

    “PD-1-expressing tumor-infiltrating T cells can be disabled by PD-L1 on the surfaces of tumor cells or other infiltrating immune cells, and blocking antibodies targeting PD-1 signaling are therefore thought to mainly affect the effector stage of the immune response (13, 55–57).”
  • PD-L1 on tumor cells or other infiltrating immune cells can disable PD-1-expressing tumor-infiltrating T cells.

    “PD-1-expressing tumor-infiltrating T cells can be disabled by PD-L1 on the surfaces of tumor cells or other infiltrating immune cells, and blocking antibodies targeting PD-1 signaling are therefore thought to mainly affect the effector stage of the immune response (13, 55–57).”

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Authors
Saito, H., Kuroda, H., Matsunaga, T., Osaki, T., & Ikeguchi, M.
Affiliations
Tottori University Hospital (JP)
Corresponding author
Saito, Hiroaki
Venue
Journal of Surgical Oncology
Publisher
Wiley
Published
2012-11-05
Volume
107
Issue
5
Pages
517-522
ISSN
  • 0022-4790 (ISSN-L)
  • 1096-9098
OpenAlex
W1498454097
Cited by
94
References
39
Citations by year
2026: 3 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 11 · 2017: 15 · 2016: 12 · 2015: 6 · 2014: 2 · 2013: 2
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Surgical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (23501285)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
PD-1, PDCD1, gastric cancer, immune evasion, CD4+ T cells, CD8+ T cells, IFN-gamma production, disease progression, tumor-infiltrating lymphocytes
MeSH terms
Aged, Female, Flow Cytometry, Humans, Interferon-gamma, Male, Monocytes, Stomach Neoplasms, CD4-Positive T-Lymphocytes, Up-Regulation, Case-Control Studies, CD8-Positive T-Lymphocytes, Lipopolysaccharide Receptors, Programmed Cell Death 1 Receptor

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