Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism
Open accessAbstract
OBJECTIVE: The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy. STUDY DESIGN: Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery. SETTING: Tertiary medical center. METHODS: Thyroid specific QOL questionnaire analysis. RESULTS: A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4. CONCLUSIONS: Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.
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Quality of life seems to depend more on the degree of hypothyroidism than the level of thyroid surgery (total or partial thyroidectomy).
“However, quality of life seems to depend more on the degree of hypothyroidism than the level of thyroid surgery (total or partial thyroidectomy) (100).”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [100]
Quality of life was lower in patients who required levothyroxine following surgery and the need for levothyroxine had a greater negative impact than the extent of surgery.
“Quality of life was lower in patients who required levothyroxine following surgery and the need for levothyroxine had a greater negative impact than the extent of surgery.83”
From Hypothyroidism (2024) · cites this paper as [83]
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- Authors
- Yaniv, D., Vainer, I., Amir, I., Robenshtok, E., Hirsch, D., Watt, T., Hilly, O., Shkedy, Y., Shpitzer, T., Bachar, G., Feinmesser, R., & Mizrachi, A.
- Affiliations
- Tel Aviv University (IL)
- Copenhagen University Hospital (DK)
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Yaniv, Dan
- ORCID
- Venue
- Journal of Surgical Oncology
- Publisher
- Wiley
- Published
- 2022-06-11
- Volume
- 126
- Issue
- 4
- Pages
- 640-648
- ISSN
- 0022-4790 (ISSN-L)
- 1096-9098
- PMC
- PMC9544480
- OpenAlex
- W4282923602
- Cited by
- 55
- References
- 21
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 9 · 2023: 5 · 2022: 3
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Surgical Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- quality of life, thyroidectomy, lobectomy, total thyroidectomy, hypothyroidism, levothyroxine therapy, thyroid cancer surgery, extent of thyroid surgery
- MeSH terms
- Humans, Hypothyroidism, Quality of Life, Thyroidectomy, Thyroxine
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