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Cited by 81Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchBlood disorders and treatments

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

The role of cells and their products in the regulation of in vitro stem cell proliferation and granulocyte development

Dexter, T. M., Spooncer, E., Toksoz, D., Lajtha, L. G.·1980·Journal of Supramolecular Structure
DOI 10.1002/jss.400130410
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Abstract

In long‐term marrow cultures haemopoiesis can be maintained in vitro for up to 6 months. Critical analysis of the cell populations produced has shown that the stem cells and their committed progeny have characteristics in common with the corresponding cell types in vivo. The maintenance of haemopoiesis in vitro is associated with the development of an appropriate inductive environment provided by bone marrow derived adherent cells. Analysis of the interactions between environmental and haemopoietic cells has been facilitated by the development of in vitro systems reproducing the naturally occurring genetic environmental defects and other systems where the development of a competent inductive environment shows a dependency upon corticosteroid hormones. Investigations have shown that stem cell proliferation may be controlled by production of opposing activities, one stimulatory for DNA synthesis, the other inhibitory. A model is proposed whereby modulation in the production of these factors is determined by the physical presence of stem cells in a proposed cellular milieu, within the adherent layer. The adherent layer, apart from acting at the level of stem cell proliferation, can also modify the response of differentiating cells (eg, GM‐CFC) to exogenous stimulatory activities. Addition of GM‐CSF or of CSF‐antiserum has no effect on haemopoiesis in long‐term cultures.

Overview

Integrity signals

Registry

Crossref · 10.1002/jss.400130410

Cites

38 of 38 references verified0 citation errors · 0 not checkable

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Verification

Claims the paper makes

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Citations

Cites

Research works printed but not linked: 10

  1. Iscove NN, 1973, Haemopoiesis in Culture: Second International Workshop, 74
  2. Dexter TM, 1978, Cold Spring Harbor Symp Quant Biol, 42, 63
  3. Reimann J, 1979, Exp Hematol, 7, 45
  4. Dexter TM, 1979, Clinics in Hematology, 453
  5. Dexter TM, 1977, Biomedicine, 27, 344
  6. ToksözD DexterTM LordBI WrightEG LajthaLG:Blood(in press).
  7. Lord BI, 1977, Biomedicine, 27, 223
  8. Frindel E, 1976, Exp Hematol, 4, 56
  9. Frindel E, 1977, Exp Hematol, 5, 74
  10. Wright EG, 1978, Biomedicine, 28, 156

Cited by

See all 81

Metadata

Authors
Dexter, T. M., Spooncer, E., Toksoz, D., & Lajtha, L. G.
Affiliations
Cancer Research UK Manchester Institute (GB)
Venue
Journal of Supramolecular Structure
Publisher
Wiley
Published
1980-01
Volume
13
Issue
4
Pages
513-524
ISSN
  • 0091-7419 (ISSN-L)
  • 1547-9366
DOI
10.1002/jss.400130410
OpenAlex
W1972839143
Cited by
81
References
38
Citations by year
2025: 1 · 2024: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2014: 1 · 2012: 2
FWCI
2.99
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8815 d)
Locations
  • Journal of Supramolecular Structure (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Blood disorders and treatments
Keywords
hematopoiesis, long-term bone marrow culture, hematopoietic stem cells, stem cell proliferation, corticosteroids, granulocyte-macrophage colony-forming cells, GM-CSF, cell-cell interactions, DNA synthesis regulation
MeSH terms
Animals, Bone Marrow, Cell Adhesion, Cell Differentiation, Cell Division, Cells, Cultured, Granulocytes, Hematopoiesis, Hematopoietic Stem Cells, Kinetics, Methods, Mice, Mutant Strains, Mice

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.