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Hydrophilic interaction chromatography coupled to MS for metabonomic/metabolomic studies
Abstract
Hydrophilic interaction chromatography (HILIC) is a relatively recently introduced mode of liquid‐phase separations. Recently, HILIC has been used for coupling to MS in metabonomic/metabolomic studies to provide a complementary tool to the widely used reversed‐phase (RP) chromatographic separations. The combination of HILIC with MS detection covers a number of polar metabolites that are typically nonretained in RPLC‐mode separations and thus enlarging the number of detected analytes. This way of metabolite profiling thus provides more comprehensive metabolome coverage than using RP chromatography alone. This review describes the applications and the utility of HILIC‐MS in metabolomic/metabonomic studies and highlights certain characteristic examples in the life and plant‐food sciences.
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Citations
Cited by
Stationary and mobile phases in hydrophilic interaction chromatography: a review
Jandera, P. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.02.047 · Cited by 707
Metabolite Measurement: Pitfalls to Avoid and Practices to Follow
Lu, W., Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., & Rabinowitz, J. D. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044952 · Cited by 462
Kuehnbaum, N. L., & Britz-McKibbin, P. (2013) · Chemical Reviews · doi:10.1021/cr300484s · Cited by 354
Retention and selectivity of stationary phases for hydrophilic interaction chromatography
Guo, Y., & Gaiki, S. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.06.052 · Cited by 310
Advances in metabolite identification
Wishart, D. S. (2011) · Bioanalysis · doi:10.4155/bio.11.155 · Cited by 284
Metadata
- Authors
- Spagou, K., Tsoukali, H., Raikos, N., Gika, H., Wilson, I. D., & Theodoridis, G.
- Venue
- Journal of Separation Science
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 33
- Issue
- 6-7
- Pages
- 716-727
- ISSN
- 1615-9306 (ISSN-L)
- 1615-9314
- OpenAlex
- W2048294518
- Cited by
- 202
- References
- 0
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spagou, K., Tsoukali, H., Raikos, N., Gika, H., Wilson, I. D., & Theodoridis, G. (2010). Hydrophilic interaction chromatography coupled to MS for metabonomic/metabolomic studies. Journal of Separation Science. https://doi.org/10.1002/jssc.200900803
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