Cited by 249Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchTrauma and Emergency Care Studies

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Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof‐of‐concept trial in physically injured patients

Stein, Murray B., Kerridge, Carol, Dimsdale, Joel E., Hoyt, David B.·2007·Journal of Traumatic Stress

DOI 10.1002/jts.20270

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Abstract

Acute physical injury is frequently associated with mental health sequelae, which then accentuate disability and worsen functional outcomes. A pharmacological prevention approach to this problem has been proposed. This proof‐of‐concept study was a double‐blind, randomized controlled trial of 14 days of the beta‐blocker propranolol ( n = 17), the anxiolytic anticonvulsant gabapentin ( n = 14), or placebo ( n = 17), administered within 48 hours of injury to patients admitted to a surgical trauma center. Of 569 accessible, potentially eligible subjects, 48 (8%) participated. Outcomes assessments were conducted at 1, 4, and 8 months postinjury. Although well tolerated, neither study drug showed a significant benefit over placebo on depressive or posttraumatic stress symptoms. Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury.

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Authors: Stein, M. B., Kerridge, C., Dimsdale, J. E., & Hoyt, D. B.
Affiliations: University of California San Diego (US)
University of California, Irvine (US)
Corresponding author: Stein, Murray B.
ORCID: Stein, Murray B.
Venue: Journal of Traumatic Stress
Publisher: Wiley
Published: 2007-12
Volume: 20
Issue: 6
Pages: 923-932
ISSN: 0894-9867 (ISSN-L)
1573-6598
DOI: 10.1002/jts.20270
OpenAlex: W1974348021
Cited by: 249
References: 55
Citations by year: 2026: 1 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 23 · 2014: 27 · 2013: 23 · 2012: 21
FWCI: 15.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 20 d)
Locations: Journal of Traumatic Stress (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r21mh062037-03)
National Institute of Mental Health (K24MH064122, K24MH64122, R21MH62037)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Keywords: post-traumatic stress disorder, pharmacological prophylaxis, propranolol, gabapentin, beta-blockers, traumatic brain injury, depressive symptoms, posttraumatic stress symptoms
MeSH terms: Gabapentin, Adolescent, Adult, Amines, California, Cyclohexanecarboxylic Acids, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Placebos, Propranolol, Stress Disorders, Post-Traumatic, Anti-Anxiety Agents, Vasodilator Agents, Wounds and Injuries

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Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof‐of‐concept trial in physically injured patients

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