Relationship of Trauma Symptoms to Amygdala‐Based Functional Brain Changes in Adolescents
Open accessAbstract
In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting‐state functional magnetic resonance imaging (R‐fMRI) in 23 healthy adolescents ages 13–17 years with no psychiatric diagnoses. Adolescents completed a self‐report trauma symptom checklist and a R‐fMRI scan. We examined the relationship of trauma symptoms to resting‐state functional connectivity of the amygdala. Increasing self‐report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long‐range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent neuroimaging studies show an impact of childhood trauma on resting-state functional brain connectivity.
“A few recent neuroimaging studies demonstrate an impact of CT on resting-state functional brain connectivity (17–20).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
Sequence-independent segmentation of magnetic resonance images
Fischl, B. R., Salat, D. H., van der Kouwe, A. J. W., Makris, N., Ségonne, F., Quinn, B. T., & Dale, A. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.016 · Cited by 2,117 · see citing works
Functional brain networks develop from a local to distributed organization
Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530 · see citing works
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960 · see citing works
Statistical analysis of activation images
Worsley, K. J. (2001) · doi:10.1093/acprof:oso/9780192630711.003.0014 · Cited by 825 · see citing works
Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
Kelly, A. M. C., Di Martino, A., Uddin, L. Q., Shehzad, Z., Gee, D. G., Reiss, P. T., Margulies, D. S., Castellanos, F. X., & Milham, M. P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn117 · Cited by 572 · see citing works
Self-citationMennes, M., Kelly, C. A. M., Zuo, X., Martino, A. D., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.002 · Cited by 355 · see citing works
Self-citationRaineki, C., Cortés, M. R., Belnoue, L., & Sullivan, R. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5843-11.2012 · Cited by 217 · see citing works
Nakao (2009) · doi:10.1016/j.jpsychires.2008.10.003 · Cited by 213 · see citing works
Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children
De Brito, S. A., Viding, E., Sebastian, C. L., Kelly, P. A., Mechelli, A., Maris, H., & McCrory, E. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02597.x · Cited by 194 · see citing works
Factors Related to Posttraumatic Stress Disorder in Adolescence
Nooner, K. B., Linares, L. O., Batinjane, J., Kramer, R. A., Silva, R., & Cloitre, M. (2012) · Trauma, Violence, & Abuse · doi:10.1177/1524838012447698 · Cited by 192 · see citing works
Self-citationChildhood trauma history differentiates amygdala response to sad faces within MDD
Grant, M. M., Cannistraci, C., Hollon, S. D., Gore, J., & Shelton, R. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.12.004 · Cited by 166 · see citing works
Garrett, A. S., Carrion, V., Kletter, H., Karchemskiy, A., Weems, C. F., & Reiss, A. (2012) · Depression and Anxiety · doi:10.1002/da.21892 · Cited by 131 · see citing works
Neuroimaging in children, adolescents and young adults with psychological trauma
Rinne-Albers, M. A. W., van der Wee, N. J. A., Lamers-Winkelman, F., & Vermeiren, R. R. J. M. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0410-1 · Cited by 69 · see citing works
Carrión, V. G., Wong, S. S., & Kletter, H. (2012) · Journal of Family Violence · doi:10.1007/s10896-012-9489-2 · Cited by 36 · see citing works
Ahmed, F. Z. B., Spottiswoode, B. S., Carey, P. D., Stein, D. J., & Seedat, S. (2012) · Neuropsychobiology · doi:10.1159/000339558 · Cited by 36 · see citing works
Voxel-Based Morphometric Gray Matter Correlates of Posttraumatic Stress Disorder
Weber, M., Killgore, W., Rosso, I., Britton, J. C., Schwab, Z., Weiner, M. R., Naomi, M., Pollack, M., & Rauch, S. (2013) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2013.04.004 · Cited by 34 · see citing works
Li, B., Liu, J., Liu, Y., et al. (2013) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2008168 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Andersson JLR Jenkinson M Smith S 2007 TR07JA2: Non-linear registration, aka spatial normalisation. FMRIB Analysis Group Technical Reports Oxford, England University of Oxford, The Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences
- Jenkinson M Beckmann CF Behrens TE Woolrich MW Smith SM 2012 FSL NeuroImage 62 782 790 10.1016/j.neuroimage.2011.09015 21979382 · DOI
Cited by
Sorted by citations
Stress and the adolescent brain
Tottenham, N., & Galván, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.030 · Cited by 324 · see citing works
Altered amygdala connectivity in urban youth exposed to trauma
Thomason, M. E., Marusak, H. A., Tocco, M. A., Vila, A. M., McGarragle, O., & Rosenberg, D. R. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv030 · Cited by 127 · see citing works
“Gee et al. (2013a) and Nooner et al. (2013) provided the first studies of early life stress and functional connectivity (FC) in children/adolescents.”
BackgroundSilveira, S., Shah, R., Nooner, K. B., Nagel, B. J., Tapert, S. F., de Bellis, M. D., & Mishra, J. (2020) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.01.011 · Cited by 68 · see citing works
Self-citationGaylord-Harden, N. K., Alli, J., Davis-Stober, C. P., & Henderson, H. (2022) · Preventive Medicine · doi:10.1016/j.ypmed.2022.107305 · Cited by 17 · see citing works
- Authors
- Nooner, K. B., Mennes, M., Brown, S., Castellanos, F. X., Leventhal, B., Milham, M. P., & Colcombe, S. J.
- Affiliations
- University of North Carolina Wilmington (US)
- Radboud University Nijmegen (NL)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Colcombe, Stanley J.
- ORCID
- Venue
- Journal of Traumatic Stress
- Publisher
- Wiley
- Published
- 2013-11-15
- Volume
- 26
- Issue
- 6
- Pages
- 784-787
- ISSN
- 0894-9867 (ISSN-L)
- 1573-6598
- PMC
- PMC4073800
- OpenAlex
- W1758209537
- Cited by
- 43
- References
- 19
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Traumatic Stress (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH094639)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- trauma symptoms, amygdala, resting-state functional connectivity, adolescents, limbic system, frontoparietal network
- MeSH terms
- Adaptation, Psychological, Adolescent, Amygdala, Female, Humans, Magnetic Resonance Imaging, Male, Mental Health, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
