The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously
Abstract
OBJECTIVES/HYPOTHESIS: Viral upper respiratory tract infections are often followed by secondary bacterial infections in the form of acute rhinosinusitis. We investigate the effect of rhinovirus infection on the expression of cell adhesion molecules and bacterial adherence to primary human nasal epithelial cells. METHODS: Cells were infected with rhinovirus serotype 16 (RV-16), and then Staphylococcus aureus, Streptococcus pneumoniae, or Hemophilus influenzae were added to the culture. Rhinovirus-induced expression of fibronectin, platelet-activating factor receptor, and carcinoembryonic antigen-related cell adhesion molecule, was assayed by confocal microscopy, real-time polymerase chain reaction, and Western blot analysis. Bacterial adhesion to cells was assessed by confocal microscopy and the fluorescence intensity of adherent bacteria was analyzed using Image-Pro Plus 5.1 (Media Cybernetics, Inc., Bethesda, MD). RESULTS: RV-16 infection significantly increased the gene and protein expression of fibronectin, platelet-activating factor receptor, and carcinoembryonic antigen-related cell adhesion molecule in nasal epithelial cells. Compared with rhinovirus-uninfected control cells, the adhesion of S. aureus, S. pneumoniae, and H. influenzae increased significantly to 2.53-fold, 1.51-fold, and 2.74-fold of control levels, respectively, in rhinovirus-infected nasal epithelial cells. CONCLUSIONS: These findings suggest that increased expression of host cell adhesion molecules may be the mechanism accounting for the increase in susceptibility to bacterial rhinosinusitis associated with rhinovirus-induced upper respiratory infections.
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“In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT (90–95), including S. pneumoniae and H. influenzae (86–88).”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [88]
In the citing paper
“Given the effects of viruses on enhancing bacterial adherence to the epithelium (86–88), it is perhaps not surprising that multiple studies of human subjects as well as in animal models have shown that viral infections are associated with increased colonization by potentially pathogenic bacteria”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [88]
In the citing paper
“Epithelium-derived cytokines and chemokines, by increasing cellular recruitment into infected airways, are believed to be responsible for damaging both infected and uninfected areas of the lung (117, 305).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [305]
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Metadata
- Authors
- Wang, J. H., Kwon, H. J., & Jang, Y. J.
- Affiliations
- Asan Medical Center (KR)
- Corresponding author
- Jang, Yong Ju
- ORCID
- Jang, Yong Ju
- Venue
- The Laryngoscope
- Publisher
- Wiley
- Published
- 2009-05-11
- Volume
- 119
- Issue
- 7
- Pages
- 1406-1411
- ISSN
- 0023-852X (ISSN-L)
- 1531-4995
- OpenAlex
- W1968063603
- Cited by
- 136
- References
- 21
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 13 · 2013: 12 · 2012: 8
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Laryngoscope (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Asan Institute for Life Science (2007-345)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- rhinovirus, bacterial adhesion, nasal epithelial cells, acute sinusitis, secondary bacterial infection, Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, adhesion molecules, fibronectin, platelet-activating factor receptor, CEACAM, upper respiratory tract infection
- MeSH terms
- Bacterial Adhesion, Carcinoembryonic Antigen, Cell Adhesion, Disease Susceptibility, Epithelial Cells, Fibronectins, Haemophilus influenzae, Humans, Nasal Mucosa, Platelet Membrane Glycoproteins, Rhinovirus, Staphylococcus aureus, Streptococcus pneumoniae, Blotting, Western, Microscopy, Confocal, Statistics, Nonparametric, Reverse Transcriptase Polymerase Chain Reaction, Receptors, G-Protein-Coupled
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