Effects of Rhinovirus Infection on the Adherence of Streptococcus pneumoniae to Cultured Human Airway Epithelial Cells
Abstract
To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-kappaB (NF-kappaB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-kappaB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection.
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In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT, including S. pneumoniae and H. influenzae.
“In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT (90–95), including S. pneumoniae and H. influenzae (86–88).”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [86]
Given the effects of viruses on enhancing bacterial adherence to the epithelium, multiple studies of human subjects as well as in animal models have shown that viral infections are associated with increased colonization by potentially pathogenic bacteria.
“Given the effects of viruses on enhancing bacterial adherence to the epithelium (86–88), it is perhaps not surprising that multiple studies of human subjects as well as in animal models have shown that viral infections are associated with increased colonization by potentially pathogenic bacteria”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [86]
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- Authors
- Ishizuka, S., Yamaya, M., Suzuki, T., Takahashi, H., Ida, S., Sasaki, T., Inoue, D., Sekizawa, K., Nishimura, H., & Sasaki, H.
- Affiliations
- Tohoku University (JP)
- University of Tsukuba (JP)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-15
- Volume
- 188
- Issue
- 12
- Pages
- 1928-1939
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2155129802
- Cited by
- 174
- References
- 45
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 11
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- rhinovirus infection, Streptococcus pneumoniae, bacterial adhesion, airway epithelial cells, tracheal epithelium, platelet-activating factor receptor, platelet-activating factor, NF-κB, pneumonia, viral-bacterial coinfection
- MeSH terms
- Bacterial Adhesion, Cells, Cultured, Epithelial Cells, Humans, Picornaviridae Infections, Platelet Activating Factor, Platelet Membrane Glycoproteins, Pneumococcal Infections, Rhinovirus, Streptococcus pneumoniae, Time Factors, Transcription Factors, Virulence, NF-kappa B, Respiratory Mucosa, Receptors, G-Protein-Coupled
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