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Cited by 404

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Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts

Open access
Medrado, Alena R.A.P., Pugliese, Lívia S., Reis, Sílvia Regina A., Andrade, Zilton A.·2003·Lasers in Surgery and Medicine

Abstract

Background and Objective: In re‐evaluating the effects of laser therapy in wound healing, the role of extracellular matrix elements and myofibroblasts, was analyzed. Study Design/Materials and Methods: Cutaneous wounds were inflicted on the back of 72 Wistar rats. Low level laser was locally applied with different energy densities. Lesions were analyzed after 24, 48, 72 hours and 5, 7, and 14 days. Tissues were studied by histology, immunohistochemistry, and electron microscopy. Results: In treated animals, the extent of edema and the number of inflammatory cells were reduced (P < 0.05), but the amount of collagen and elastic fibers appeared slightly increased. Desmin/smooth muscle alpha‐actin‐phenotype myofibroblasts were statistically more prominent on the 3rd day after surgery (P < 0.05) in treated wounds than in controls. Treatment with a dosage of 4 J/cm 2 was superior to that with 8 J/cm 2. Conclusions: Laser therapy reduced the inflammatory reaction, induced increased collagen deposition and a greater proliferation of myofibroblasts in experimental cutaneous wounds. Lasers Surg. Med. 32:239–244, 2003. © 2003 Wiley‐Liss, Inc.

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Metadata

Authors
Medrado, A. R. A. P., Pugliese, L. S., Reis, S. R. A., & Andrade, Z. A.
Venue
Lasers in Surgery and Medicine
Publisher
Wiley
Published
2003-02-25
Volume
32
Issue
3
Pages
239-244
ISSN
  • 0196-8092 (ISSN-L)
  • 1096-9101
OpenAlex
W2031942035
Cited by
404
References
1
FWCI
6.98
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts. https://app.cochat.ai/papers/10.1002/lsm.10126
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Medrado, A. R. A. P., Pugliese, L. S., Reis, S. R. A., & Andrade, Z. A. (2003). Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts. Lasers in Surgery and Medicine. https://doi.org/10.1002/lsm.10126

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