The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Association between sarcopenia and the risk of serious infection among adults undergoing liver transplantation
Open accessAbstract
Although sarcopenia (muscle loss) is associated with increased mortality after liver transplantation, its influence on other complications is less well understood. We examined the association between sarcopenia and the risk of severe posttransplant infections among adult liver transplant recipients. By calculating the total psoas area (TPA) on preoperative computed tomography scans, we assessed sarcopenia among 207 liver transplant recipients. The presence or absence of a severe posttransplant infection was determined by a review of the medical chart. The influence of posttransplant infections on overall survival was also assessed. We identified 196 episodes of severe infections among 111 patients. Fifty-six patients had more than 1 infection. The median time to the development of an infection was 27 days (interquartile range = 13-62 days). When the patients were grouped by TPA tertiles, patients in the lowest tertile had a greater than 4-fold higher chance of developing a severe infection in comparison with patients in the highest tertile (odds ratio = 4.6, 95% confidence interval = 2.25-9.53). In a multivariate analysis, recipient age (hazard ratio = 1.04, P = 0.02), pretransplant TPA (hazard ratio = 0.38, P < 0.01), and pretransplant total bilirubin level (hazard ratio = 1.05, P = 0.02) were independently associated with the risk of developing severe infections. Patients with severe posttransplant infections had worse 1-year survival than patients without infections (76% versus 92%, P = 0.003). In conclusion, among patients undergoing liver transplantation, a lower TPA was associated with a heightened risk for posttransplant infectious complications and mortality. Future efforts should focus on approaches for assessing and mitigating vulnerability in patients undergoing transplantation. Liver Transpl 19:1396–1402, 2013. © 2013 AASLD.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Iannuzzi-Sucich, M., Prestwood, K. M., & Kenny, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.12.m772 · Cited by 890 · cited 2×
“To account for known sex influences on TPA in our analysis, we first grouped patients into sex-stratified TPA tertiles so that each tertile contained similar proportions of men and women.(9,18) We then compared patient demographics, preoperative characteristics, and preoperative laboratory values as well as donor char…”
BackgroundMethodReview Article: Sarcopenia: Causes, Consequences, and Preventions
Marcell, T. J. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.10.m911 · Cited by 536 · cited 1×
“mortality and morbidity risk across diverse patient groups.(7-10) Although the influence of sarcopenia on the overall health of older adults has been well recognized, the potential impact of frailty on surgical outcomes has only recently generated interest.”
Background
Cited by
Montano-Loza, A. J., Angulo, P., Meza-Junco, J., Prado, C. M. M., Sawyer, M. B., Beaumont, C., Esfandiari, N., Ma, M., & Baracos, V. E. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12039 · Cited by 512
A multicenter study to define sarcopenia in patients with end-stage liver disease
Carey, E. J., Lai, J. C., Wang, C. W., Dasarathy, S., Lobach, I., Montano‐Loza, A. J., Dunn, M. A., & for the Fitness, L. E. (2017) · Liver Transplantation · doi:10.1002/lt.24750 · Cited by 498
van Vugt, J. L. A., Levolger, S., de Bruin, R. W. F., van Rosmalen, J., Metselaar, H. J., & IJzermans, J. N. M. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13732 · Cited by 361
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Robbins, P. D., Jurk, D., Khosla, S., Kirkland, J. L., LeBrasseur, N. K., Miller, J. D., Passos, J. F., Pignolo, R. J., Tchkonia, T., & Niedernhofer, L. J. (2021) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-050120-105018 · Cited by 360
“Older persons with low muscle mass experience higher rates of surgical complications and infections (48), delayed recovery (49), chemotherapy toxicity (50), and disease-specific and all-cause mortality (51).”
BackgroundSinclair, M., Gow, P. J., Grossmann, M., & Angus, P. W. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13549 · Cited by 316
Frailty phenotypes, disability, and outcomes in adult candidates for lung transplantation
Singer, J. P., Diamond, J. M., Gries, C. J., McDonnough, J., Blanc, P. D., Shah, R., Dean, M. Y., Hersh, B., Wolters, P. J., Tokman, S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1150oc · Cited by 224
Duarte‐Rojo, A., Ruiz‐Margáin, A., Montaño‐Loza, A. J., Macías‐Rodríguez, R. U., Ferrando, A., & Kim, W. R. (2018) · Liver Transplantation · doi:10.1002/lt.24958 · Cited by 221
Sharma, P., Parikh, N. D., Yu, J., Barman, P., Derstine, B. A., Sonnenday, C. J., Wang, S. C., & Su, G. L. (2016) · Liver Transplantation · doi:10.1002/lt.24458 · Cited by 83
Metadata
- Authors
- Krell, R. W., Kaul, D. R., Martin, A. R., Englesbe, M. J., Sonnenday, C. J., Cai, S., & Malani, P. N.
- Venue
- Liver Transplantation
- Published
- 2013-12
- Volume
- 19
- Issue
- 12
- Pages
- 1396-1402
- ISSN
- 1527-6465 (ISSN-L)
- OpenAlex
- W2514207831
- Cited by
- 259
- References
- 4
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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