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Advances in Mucoadhesion and Mucoadhesive Polymers
Abstract
Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non‐ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives. magnified image
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Citations
Cites
The basics and underlying mechanisms of mucoadhesion
SMART, J. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.001 · Cited by 1,167
Cited by
Barua, S., & Mitragotri, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.008 · Cited by 1,257
Xu, W., Ling, P., & Zhang, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/340315 · Cited by 595
Multifaceted Design and Emerging Applications of Tissue Adhesives
Ma, Z., Bao, G., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202007663 · Cited by 269
Microneedles as the technique of drug delivery enhancement in diverse organs and tissues
Rzhevskiy, A. S., Singh, T. R. R., Donnelly, R. F., & Anissimov, Y. G. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.048 · Cited by 266
Principles of pharmacology in the eye
Awwad, S., Mohamed Ahmed, A. H. A., Sharma, G., Heng, J. S., Khaw, P. T., Brocchini, S., & Lockwood, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14024 · Cited by 224
Metadata
- Authors
- Khutoryanskiy, V. V.
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2010-12-27
- Volume
- 11
- Issue
- 6
- Pages
- 748-764
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2046886904
- Cited by
- 655
- References
- 1
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
