Preparation of Biocompatible Aggregation‐I nduced Emission Homopolymeric Nanoparticles for Cell Imaging
Abstract
A series of new homopolymers with various degrees of polymerization derived from vinyl tetraphenylethene, that is, poly[2‐(4‐vinylphenyl)ethene‐1,1,2‐triyl)tribenzene] homopolymers, is synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization. The homopolymers exhibit a significant aggregation‐induced emission (AIE) effect and an ability to assemble themselves into AIE polymer nanoparticles (NPs) during precipitation in a water/tetrahydrofuran (THF) mixture. The NPs also exhibit good dispersibility, stability, and biocompatibility. The AIE polymer NPs are used in imaging studies of HeLa cells.
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Controlling the Fluorescence Performance of AIE Polymers by Controlling the Polymer Microstructure
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- Authors
- Ma, C., Ling, Q., Xu, S., Zhu, H., Zhang, G., Zhou, X., Chi, Z., Liu, S., Zhang, Y., & Xu, J.
- Affiliations
- Sun Yat-sen University (CN)
- Corresponding author
- Zhang, Ge
- Chi, Zhenguo
- Xu, Jiarui
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2013-09-17
- Volume
- 14
- Issue
- 2
- Pages
- 235-243
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2155738879
- Cited by
- 60
- References
- 56
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 6
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Macromolecular Bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51173210, 51073177)
- Fundamental Research Funds for the Central Universities and Natural Science Foundation of Guangdong (S2011020001190)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- aggregation-induced emission, RAFT polymerization, homopolymers, polymeric nanoparticles, self-assembly, biocompatibility, cell imaging, HeLa cells
- MeSH terms
- Biocompatible Materials, Furans, HeLa Cells, Humans, Nanoparticles, Molecular Imaging, Polymerization, Chemistry Techniques, Synthetic
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