Cited by 36Luminescence and Fluorescent MaterialsAdvanced Polymer Synthesis and CharacterizationMolecular Sensors and Ion Detection

Fluorescent Glycopolymer Nanoparticles Based on Aggregation‐Induced Emission Dyes: Preparation and Bioimaging Applications

Wang, Ke, Zhang, Xiaoyong, Zhang, Xiqi, Yang, Bin, Li, Zhen, Zhang, Qingsong, Huang, Zengfang, Wei, Yen·2015·Macromolecular Chemistry and Physics

Abstract

Aggregation‐induced emission (AIE) dye‐based fluorescent glycopolymers nanoparticles (FGNs) are synthesized with abundant carbohydrate groups on the surface for the first time. This is carried out firstly by free radical polymerization between AIE monomer (PhE) and a renewable biobased monomer itaconic anhydride (ITA), then by the ring‐opening reaction between ITA and glucosamine hydrochloride, to obtain glycopolymers with plenty of glycosyl groups on them. The resulted amphiphilic glycopolymer is prone to self‐assemble into nanoparticles with high water dispersibility due to the surplus carboxyl groups and glycosyl groups covered on the surface, which can also be further functionalized. The obtained nanoparticles demonstrate strong fluorescence emission, owning to the AIE dyes in the core of nanoparticles. Biocompatibility evaluation and cell uptake behavior of the nanoparticles are further investigated to explore their potential biomedical applications; the demonstrated excellent biocompatibility makes them promising for cell imaging. image

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Crossref · 10.1002/macp.201400564

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Authors
Wang, K., Zhang, X., Zhang, X., Yang, B., Li, Z., Zhang, Q., Huang, Z., & Wei, Y.
Affiliations
Tsinghua University (CN)
Corresponding author
Wei, Yen
Venue
Macromolecular Chemistry and Physics
Publisher
Wiley
Published
2015-01-21
Volume
216
Issue
6
Pages
678-684
ISSN
  • 1022-1352 (ISSN-L)
  • 1521-3935
OpenAlex
W1973228319
Cited by
36
References
39
Citations by year
2026: 1 · 2025: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 8 · 2015: 9
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
Macromolecular Chemistry and Physics (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
aggregation-induced emission, itaconic anhydride, glucosamine hydrochloride, ring-opening polymerization, radical polymerization, amphiphilic polymers, self-assembly, water dispersibility, biocompatibility, cellular uptake, cell imaging

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