A facile strategy for preparing tough, self-healing double-network hyaluronic acid hydrogels inspired by mussel cuticles
Abstract
Compared with hydrogel‐like biological tissues such as cartilage, muscles, and blood vessels, current hyaluronic acid hydrogels often suffer from poor toughness and limited self‐healing properties. Herein, a facile and generalizable strategy inspired by mussel cuticles is presented to fabricate tough and self‐healing double‐network hyaluronic acid hydrogels. These hydrogels are composed of ductile, reversible Fe3+‐catechol interaction primary networks, and secondarily formed brittle, irreversible covalent networks. Based on this design strategy, the hyaluronic acid hydrogels are demonstrated to exhibit reinforced mechanical strength while maintaining a rapid self‐healing property. In addition, by simply regulating pH or UV irradiation time, the mechanical properties of the hydrogels can be regulated conveniently through variations between the primary and secondary networks.
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Using classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin, and synthetic polymers, such as PEG-based polymers.
“Using these classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin (GT), and synthetic polymers, such as polyethylene glycol (PEG)-based polymers [45,47,51,52,53,54,55].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [52]
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Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
- Authors
- Guo, Z., Mi, S., & Sun, W.
- Affiliations
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Tsinghua Shenzhen International Graduate School (CN)
- Corresponding author
- Sun, Wei
- Venue
- Macromolecular Materials and Engineering
- Publisher
- Wiley
- Published
- 2019-02-08
- Volume
- 304
- Issue
- 4
- ISSN
- 1438-7492 (ISSN-L)
- 1439-2054
- OpenAlex
- W2914007934
- Cited by
- 33
- References
- 0
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Materials and Engineering (publishedVersion)
- Funders
- fundamental research of Shenzhen (JCYJ20170412101508433, JCYJ20160509154841455, JCYJ 20160509154951210)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- hyaluronic acid hydrogel, double-network hydrogel, self-healing hydrogels, covalent cross-linking, tough hydrogels, pH-responsive hydrogels, mechanical reinforcement
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