Mussel-inspired hydrogel composite with multi-stimuli responsive behavior
Abstract
A mussel‐inspired adhesive hydrogel with pH, temperature, and near‐infrared (NIR) light–responsive behavior is designed. The hydrogel system is formulated by combining chitosan modified with catechol motifs, thermo‐responsive poly(N‐isopropylacrylamide) terminated with catechols, and light‐absorbing polypyrrole nanoparticles (PpyNPs). The effects of catechol concentration, molar ratio of Fe3+ to catechol units, pH, and the incorporation of the PpyNPs on the mechanical property of the formed hydrogel are investigated. The responsive behaviors of the resulting hydrogel composite to pH, temperature, and NIR light are also demonstrated. The obtained hydrogel also shows promising adhesive property to glass and steel substrates. It is anticipated that the fabricated adhesive hydrogel with multi‐responsive behavior, especially NIR light response, can potentially be useful in a wide range of biomedical applications, such as remotely controlled release systems and removable sealant materials.
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Due to the instability of the formed imine bond, the sodium borohydride (NaBH4)-mediated reductive amination reaction is usually necessary.
“Due to the instability of the formed imine bond, the sodium borohydride (NaBH4)-mediated reductive amination reaction is usually necessary [49,50].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [49]
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Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“This method utilizes the Schi ff base reactions between the aldehyde polysaccharides and 3,4-dihydroxyphenethylamine [48] or between 3,4-dihydroxybenzaldehyde and amino-containing polysaccharides [49].”
BackgroundMethod
- Authors
- Yan, Y., Rong, L., Ge, J., Tiu, B. D. B., Cao, P., & Advincula, R. C.
- Affiliations
- Case Western Reserve University (US)
- Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland OH 44106 USA
- University of California, Berkeley (US)
- Chemical Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37830 USA
- Venue
- Macromolecular Materials and Engineering
- Publisher
- Wiley
- Published
- 2019-04-16
- Volume
- 304
- Issue
- 7
- ISSN
- 1438-7492 (ISSN-L)
- 1439-2054
- OpenAlex
- W2939850321
- Cited by
- 18
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 5 · 2020: 3 · 2019: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Materials and Engineering (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Science Foundation (NSF‐1608457)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Keywords
- chitosan, catechol, poly(N-isopropylacrylamide), polypyrrole nanoparticles, pH-responsive, temperature-responsive, hydrogel mechanical properties, adhesive properties, Fe3+ coordination, controlled release
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