Integrated Design of a Mussel‐Inspired Hydrogel Biofilm Composite Structure to Guide Bone Regeneration
Abstract
Ideal biomedically engineered hydrogels should imitate the physiological environment of natural bone tissue healing. The healing ability of soft tissue is stronger than that of bone tissue, thus leading to premature growth of soft tissue into the bone tissue area of the defect and resulting in poor bone tissue healing at the defect site. In addition, good cellular affinity is necessary to allow for postimplantation fusion with surrounding tissues. Inspired by the adhesion mechanism of natural mussels, a polydopamine‐polyacrylamide (PDA‐PAM) single‐network hydrogel and a PDA‐PAM/ACP hydrogel composed of amorphous hydroxyapatite (ACP) is designed to maintain sufficient free catechol groups in the hydrogel by preventing excessive oxidation of dopamine. The hydrogels are found to confer a strong healing ability without stimulation and to have cellular affinity. More notably, separation of the ACP layer and PDA‐PAM hydrogel is not easy to achieve in a synthetic hydrogel. It is found that the hydrogels (PDA‐PAM/ACP) promote bone formation. The gel up‐regulates the expression of osteogenic genes including alkaline phosphatase, runt‐related transcription factor 2, and osteocalcin. In vivo, 8‰ PDA‐PAM/ACP gel is found to effectively repair skull defects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PDA-PAM/ACP hydrogels stimulate bone formation, evidenced by high expression of ALP (~2.5-fold), Runx2 (~1.2-fold), and OCN (~<1-fold) at 14 days of culture.
“It was determined that the PDA-PAM/ACP hydrogels stimulate bone formation, evidenced by the high expression of ALP (~2.5-fold), Runx2 (~1.2-fold), and OCN (~<1-fold) involved in the osteogenic activity at 14 days of culture.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [63]
8% PDA-PAM/ACP gel efficiently repairs skull defects in vivo.
“Remarkably, 8% PDA-PAM/ACP gel efficiently repairs skull defects in vivo.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [63]
Cited by
Sorted by citations
Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“proposed combining a polydopamine-polyacrylamide (PDA-PAM) single-network hydrogel and a PDA-PAM/ACP hydrogel consisting of ACP by blocking the extreme oxidation of DA [63].”
BackgroundPolydopamine-Modified functional materials promote bone regeneration
Wang, J., Cui, Y., Zhang, B., Sun, S., Xu, H., Yao, M., Wu, D., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112655 · Cited by 56 · see citing works
- Authors
- Lin, H., Fu, Y., Gao, Y., & Mo, A.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Mo, Anchun
- Venue
- Macromolecular Materials and Engineering
- Publisher
- Wiley
- Published
- 2020-03-20
- Volume
- 305
- Issue
- 5
- ISSN
- 1438-7492 (ISSN-L)
- 1439-2054
- OpenAlex
- W3010681461
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Materials and Engineering (publishedVersion)
- Funders
- National Basic Research Program of China (2016YFA0201703/2016YFA0201700)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- mussel-inspired hydrogel, polydopamine, polyacrylamide, amorphous calcium phosphate, bone regeneration, bone defect repair, catechol groups, hydrogel adhesion, osteogenic differentiation, cranial defects, biomimetic materials, composite hydrogels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
