The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Structural characterization of flavonoid glycosides by multi‐stage mass spectrometry
Abstract
Flavonoids are secondary plant metabolites of great structural variety and high medicinal significance. The search for new chemical entities and the quality control of flavonoid containing natural products require easy‐to‐use but reliable and robust analytical methodologies. For structural elucidation of flavonoids and their glycosides, nuclear magnetic resonance (NMR) and mass spectroscopy (MS) are the generally used techniques. In phytochemical analyses, however, high amounts of flavonoids are difficult to isolate for NMR, thus low sample volume requiring MS based methods are emerging. This review summarizes and compares currently available methods for structural elucidation of flavonoids by LC–MS and LC–MSn, and focuses on the identification options of unknown flavonoid glycosides in complex samples (e.g., plant extracts) with the emphasis on the differentiation of isomeric compounds. © 2008 Wiley Periodicals, Inc., Mass Spec Rev 29:1–16, 2010
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Cites
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Cited by
Plant Flavonoids: Chemical Characteristics and Biological Activity
Dias, M. C., Pinto, D. C. G. A., & Silva, A. M. S. (2021) · Molecules · doi:10.3390/molecules26175377 · Cited by 1,512
Current approaches and challenges for the metabolite profiling of complex natural extracts
Wolfender, J.-L., Marti, G., Thomas, A., & Bertrand, S. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.091 · Cited by 635
Dalisay, D. S., Kim, K. W., Lee, C., Yang, H., Rübel, O., Bowen, B. P., Davin, L. B., & Lewis, N. G. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00023 · Cited by 157
Metadata
- Authors
- Vukics, V., & Guttman, A.
- Venue
- Mass Spectrometry Reviews
- Publisher
- Wiley
- Published
- 2008-12-30
- Volume
- 29
- Issue
- 1
- Pages
- 1-16
- ISSN
- 0277-7037 (ISSN-L)
- 1098-2787
- OpenAlex
- W2059455122
- Cited by
- 337
- References
- 75
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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