The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies
Abstract
Metabonomics and metabolomics represent one of the three major platforms in systems biology. To perform metabolomics it is necessary to generate comprehensive “global” metabolite profiles from complex samples, for example, biological fluids or tissue extracts. Analytical technologies based on mass spectrometry (MS), and in particular on liquid chromatography–MS (LC–MS), have become a major tool providing a significant source of global metabolite profiling data. In the present review we describe and compare the utility of the different analytical strategies and technologies used for MS‐based metabolomics with a particular focus on LC–MS. Both the advantages offered by the technology and also the challenges and limitations that need to be addressed for the successful application of LC–MS in metabolite analysis are described. Data treatment and approaches resulting in the detection and identification of biomarkers are considered. Special emphasis is given to validation issues, instrument stability, and QA/quality control (QC) procedures. © 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:884–906, 2011
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Kind, T., & Fiehn, O. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-105 · Cited by 1,201
Data processing for mass spectrometry-based metabolomics
Katajamaa, M., & Orešič, M. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.04.021 · Cited by 616
Web-based resources for mass-spectrometry-based metabolomics: a user’s guide
Tohge, T., & Fernie, A. R. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.02.004 · Cited by 152
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Chen, R., Mias, G. I., Li-Pook-Than, J., Jiang, L., Lam, H. Y. K., Chen, R., Miriami, E., Karczewski, K. J., Hariharan, M., Dewey, F. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.009 · Cited by 1,291
Current approaches and challenges for the metabolite profiling of complex natural extracts
Wolfender, J.-L., Marti, G., Thomas, A., & Bertrand, S. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.091 · Cited by 635
Metabolite Measurement: Pitfalls to Avoid and Practices to Follow
Lu, W., Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., & Rabinowitz, J. D. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044952 · Cited by 462
Mass spectrometric based approaches in urine metabolomics and biomarker discovery
Khamis, M. M., Adamko, D. J., & El‐Aneed, A. (2017) · Mass Spectrometry Reviews · doi:10.1002/mas.21455 · Cited by 342
Integration of GC–MS and LC–MS for untargeted metabolomics profiling
Zeki, Ö. C., Eylem, C. C., Reçber, T., Kır, S., & Nemutlu, E. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113509 · Cited by 336
Metadata
- Authors
- Theodoridis, G., Gika, H. G., & Wilson, I. D.
- Venue
- Mass Spectrometry Reviews
- Publisher
- Wiley
- Published
- 2011-03-07
- Volume
- 30
- Issue
- 5
- Pages
- 884-906
- ISSN
- 0277-7037 (ISSN-L)
- 1098-2787
- OpenAlex
- W2170786148
- Cited by
- 218
- References
- 3
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
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