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Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome

Evans, Andrew H., Katzenschlager, Regina, Paviour, Dominic, O'Sullivan, John D., Appel, Silke, Lawrence, Andrew D., Lees, Andrew J.·2004·Movement Disorders

Abstract

Punding is a term that was coined originally to describe complex prolonged, purposeless, and stereotyped behaviour in chronic amphetamine users. A structured interview of 50 patients with higher dopamine replacement therapy requirements (>800 levodopa equivalent units/day) from 123 unselected patients with Parkinson's disease (PD) from a PD clinic identified 17 (14%) patients with punding. Punding was acknowledged as disruptive and unproductive by the patients themselves, but forcible attempts by family to interrupt the behaviour led to irritability and dysphoria. Punding was associated with very high doses of dopamine replacement therapy often related to a pattern of chronic inappropriate overuse of dopaminergic medication. We believe that this is an underreported, socially disabling phenomenon that is commonly associated with the syndrome of dopamine dysregulation and is phenomenologically distinct from both obsessive‐compulsive disorder and mania. © 2004 Movement Disorder Society

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Metadata

Authors
Evans, A. H., Katzenschlager, R., Paviour, D., O'Sullivan, J. D., Appel, S., Lawrence, A. D., & Lees, A. J.
Venue
Movement Disorders
Publisher
Wiley
Published
2004-02-10
Volume
19
Issue
4
Pages
397-405
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
OpenAlex
W2012886729
Cited by
474
References
4
FWCI
10.55
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome. https://app.cochat.ai/papers/10.1002/mds.20045
The paper
Evans, A. H., Katzenschlager, R., Paviour, D., O'Sullivan, J. D., Appel, S., Lawrence, A. D., & Lees, A. J. (2004). Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome. Movement Disorders. https://doi.org/10.1002/mds.20045

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