Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
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Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson's disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson's disease patients with impulse control disorders. We describe results of a [(11)C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder.
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When familiar or relevant gambling cues are present, they produce an exaggerated striatal dopamine response.
“which when present instead produce an exaggerated striatal dopamine response (T. D. L. Steeves et al., 2009).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as T. D. L. Steeves et al., 2009
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“However, it has been suggested that such contradictory reports can be explained by the absence of familiar or relevant gambling cues during laboratory testing (Leyton & Vezina, 2012), which when present instead produce an exaggerated striatal dopamine response (T. D. L. Steeves et al., 2009).”
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- Authors
- Steeves, T. D. L., Miyasaki, J., Zurowski, M., Lang, A. E., Pellecchia, G., Van Eimeren, T., Rusjan, P., Houle, S., & Strafella, A. P.
- Affiliations
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-03
- Volume
- 132
- Issue
- 5
- Pages
- 1376-1385
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3479148
- OpenAlex
- W2159056914
- Cited by
- 502
- References
- 79
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 22 · 2020: 64 · 2019: 24 · 2018: 27 · 2017: 25 · 2016: 19 · 2015: 38 · 2014: 42 · 2013: 55 · 2012: 39
- FWCI
- 52.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ontario Problem Gambling Research Centre
- Canadian Institutes of Health Research (64423)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- gambling addiction, Parkinson's disease, dopamine release, dopamine agonists, impulse control disorders, ventral striatum, [11C]raclopride, dopamine receptor binding, addiction vulnerability, gambling behavior
- MeSH terms
- Aged, Analysis of Variance, Carbon Radioisotopes, Corpus Striatum, Dopamine, Female, Gambling, Humans, Male, Middle Aged, Parkinson Disease, Protein Binding, Case-Control Studies, Dopamine Antagonists, Raclopride, Positron-Emission Tomography
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