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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

Open access
Hely, Mariese A., Reid, Wayne G.J., Adena, Michael A., Halliday, Glenda M., Morris, John G.L.·2008·Movement Disorders
DOI 10.1002/mds.21956
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Abstract

After 20 years follow‐up of newly diagnosed patients with Parkinson's disease (PD), 100 of 136 (74%) have died. The mortality rate fell in the first 3 years of treatment, then rose compared to the general population, the standardized mortality ratio from 15 to 20 years reaching 3.1. Drug induced dyskinesia and end of dose failure were experienced by most patients, but the main current problems relate to the non‐levodopa responsive features of the disease. Dementia is present in 83% of 20‐year survivors. Dementia correlates with increasing age and probably reflects an interplay of multiple pathologies. Seventeen people with dementia had postmortems. Eight had diffuse Lewy bodies as the only cause of dementia, while others had mixed neuropathology. Only one person lives independently and 48% are in nursing homes. Excessive daytime sleepiness is noted in 70%, falls have occurred in 87%, freezing in 81%, fractures in 35%, symptomatic postural hypotension in 48%, urinary incontinence in 71%, moderate dysarthria in 81%, choking in 48%, and hallucinations in 74%. The challenge is to understand the cellular mechanisms underlying the diverse features of advanced PD that go far beyond a lack of dopamine. © 2008 Movement Disorder Society

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Metadata

Authors
Hely, M. A., Reid, W. G. J., Adena, M. A., Halliday, G. M., & Morris, J. G. L.
Venue
Movement Disorders
Publisher
Wiley
Published
2008-04-24
Volume
23
Issue
6
Pages
837-844
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
DOI
10.1002/mds.21956
OpenAlex
W2016109926
Cited by
2,246
References
7
FWCI
40.27
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
National Health and Medical Research Council of Australia

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CoChat. (2026). Citation check: The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years. https://app.cochat.ai/papers/10.1002/mds.21956
The paper
Hely, M. A., Reid, W. G. J., Adena, M. A., Halliday, G. M., & Morris, J. G. L. (2008). The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years. Movement Disorders. https://doi.org/10.1002/mds.21956

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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