CoChat
Sign Up
Cited by 142Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?

Hinnell, Claire, Hurt, Catherine S., Landau, Sabine, Brown, Richard G., Samuel, Michael, on behalf of the PROMS‐PD Study Group·2012·Movement Disorders
DOI 10.1002/mds.23961
Open this paper in CoChat — free account

Abstract

Evidence suggests that both motor and nonmotor symptoms contribute to health status in Parkinson's disease. Less clear is how much change in health status can be expected if these clinical variables change. In addition, anxiety, separate from depression, has rarely been examined as a predictor of health status. We used hierarchical multiple regression analysis and standardized beta coefficients in a prevalent cohort of 462 patients with Parkinson's disease to explore the relative impact on health status (measured using the Parkinson's Disease Questionnaire) of 5 well‐recognized symptom domains in Parkinson's disease: motor signs, depression, anxiety, cognition, and other nonmotor symptoms. In the health status scores, 19.6% of variance was explained by age, number of comorbidities, disease duration, and levodopa equivalent dose. Younger age predicted worse health status. A full regression model containing baseline variables and all 5 symptom domains explained 56% of the variance in health status. The standardized beta coefficient for depression was 2.1, 1.6, and 1.3 times that of motor signs, anxiety, and other nonmotor symptoms, respectively. Our findings provide a ranking order of clinical variables for their relative impact on health status in Parkinson's disease and show that depression has more than twice the impact of motor signs on health status. Anxiety and other nonmotor symptoms are also important separate determinants of poor health status in Parkinson's disease. Our results will help to guide the development of individual care and service planning for patients with Parkinson's disease. © 2011 Movement Disorder Society

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/mds.23961

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 42 references

1 of the 42 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Items 101–141 of 141

Related

See all

Metadata

Authors
Hinnell, C., Hurt, C. S., Landau, S., Brown, R. G., Samuel, M., & on behalf of the PROMS‐PD Study Group
Affiliations
  • Kings Health Partners (GB)
  • King's College London (GB)
  • William Harvey Hospital (GB)
Corresponding author
Samuel, Michael
ORCID
Venue
Movement Disorders
Publisher
Wiley
Published
2011-09-27
Volume
27
Issue
2
Pages
236-241
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
DOI
10.1002/mds.23961
OpenAlex
W2029474945
Cited by
142
References
42
Citations by year
2026: 5 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 13 · 2021: 8 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 7
FWCI
6.70
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Movement Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • City Research Online (City University London) (acceptedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Parkinson's UK (J-0601)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease, health status, non-motor symptoms, motor symptoms, depression, anxiety, cognition, Parkinson's Disease Questionnaire, levodopa equivalent daily dose, comorbidities, disease duration
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Anxiety, Depression, Disability Evaluation, Female, Health Status, Humans, Male, Middle Aged, Parkinson Disease, Quality of Life, Surveys and Questionnaires, Regression Analysis, Severity of Illness Index, Cohort Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review