The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Abstract
We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PD is strongly associated with REM sleep behaviour disorder, as well as excessive daytime sleepiness, insomnia and restless legs syndrome.
“PD, in particular, is strongly associated with rapid eye moment (reM) sleep behaviour disorder (RBD), as well as excessive daytime sleepiness, insomnia and restless legs syndrome270–273.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [270]
Psychological distress, such as anxiety and depressive symptoms, is prevalent among individuals with PD.
“Psychological distress, such as anxiety and depressive symptoms, are prevalent among individuals with PD.”
The incidence of anxiety and depression in PD is 27.6 to 56%, which is much higher than in people with other chronic illnesses.
“The incidence of anxiety and depression in this group is 27.6 to 56%, which is much higher than that in people with other chronic illnesses [3–9].”
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works
Measuring Health: A Guide to Rating Scales and Questionnaires
McDowell, I., & Newell, C. (1987) · Cited by 4,207 · see citing works
The FAB: A frontal assessment battery at bedside
Dubois, B., Slachevsky, A., Litvan, I., & Pillon, B. (2000) · Neurology · doi:10.1212/wnl.55.11.1621 · Cited by 3,913 · see citing works
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822 · see citing works
Non-motor symptoms of Parkinson's disease: diagnosis and management
Chaudhuri, K. R., Healy, D. G., & Schapira, A. H. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70373-8 · Cited by 2,807 · see citing works
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306 · see citing works
Recent Developments in Parkinson's Disease
Hurtig, H. I. (1987) · Neurology · doi:10.1212/wnl.37.5.893 · Cited by 1,926 · see citing works
Measuring Health: A Guide to Rating Scales and Questionnaires
Anderson, J. C. (1997) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199711000-00018 · Cited by 1,534 · see citing works
Peto, V., Jenkinson, C., Fitzpatrick, R., & Greenhall, R. (1995) · Quality of Life Research · doi:10.1007/bf02260863 · Cited by 1,204 · see citing works
Chaudhuri, K. R., Martinez‐Martin, P., Schapira, A. H. V., Stocchi, F., Sethi, K., Odin, P., Brown, R. G., Koller, W., Barone, P., MacPhee, G., et al. (2006) · Movement Disorders · doi:10.1002/mds.20844 · Cited by 1,100 · cited 1× · see citing works
“naire for PD (NMSQuest) has been developed and validated.(8,9) It considers 30 items distributed in nine different domains: gastrointestinal, urinary, memory, hallucinations, depression/anxiety, sexual function, car-”
MethodSelf-citationIranzo, Á., Molinuevo, J. L., Santamaría, J., Serradell, M., Martı́, M. J., Valldeoriola, F., & Tolosa, E. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70476-8 · Cited by 950 · see citing works
The mini‐mental state examination: Normative study of an Italian random sample
Measso, G., Cavarzeran, F., Zappalà, G., Lebowitz, B. D., Crook, T. H., Pirozzolo, F. J., Amaducci, L. A., Massari, D. C., & Grigoletto, F. (1993) · Developmental Neuropsychology · doi:10.1080/87565649109540545 · Cited by 817 · see citing works
Predictors of Nursing Home Placement in Parkinson's Disease: A Population‐Based, Prospective Study
Aarsland, D., Larsen, J. P., Tandberg, E., & Laake, K. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb06891.x · Cited by 811 · see citing works
The Frontal Assessment Battery (FAB): normative values in an Italian population sample
Appollonio, I. M., Leone, M. E., Isella, V., Piamarta, F., Consoli, T., Villa, M. L., Forapani, E., Russo, A., & Nichelli, P. (2005) · Neurological Sciences · doi:10.1007/s10072-005-0443-4 · Cited by 674 · see citing works
Nonmotor fluctuations in Parkinson’s disease: Frequent and disabling
Witjas, T., Kaphan, E., Azulay, J. P., Blin, O., Ceccaldi, M., Pouget, J., Poncet, M., & Chérif, A. A. (2002) · Neurology · doi:10.1212/wnl.59.3.408 · Cited by 642 · see citing works
Martínez‐Martín, P., Schapira, A. H. V., Stocchi, F., Sethi, K. D., Odin, P., Macphee, G. J. A., Brown, R. G., Naidu, Y., Clayton, L. M. S., Abe, K., et al. (2007) · Movement Disorders · doi:10.1002/mds.21586 · Cited by 556 · see citing works
Self-citationQuality of life in Parkinson's disease: the relative importance of the symptoms
Rahman, S., Griffin, H. J., Quinn, N. P., & Jahanshahi, M. (2008) · Movement Disorders · doi:10.1002/mds.21667 · Cited by 532 · see citing works
Depression in Parkinson??s Disease
STARKSTEIN, S. E., Preziosi, T. J., BOLDUC, P. L., & ROBINSON, R. G. (1990) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199001000-00005 · Cited by 482 · see citing works
Excessive daytime sleepiness and subsequent development of Parkinson disease
Abbott, R. D., Ross, G. W., White, L. R., Tanner, C. M., Masaki, K., Nelson, J. S., Curb, J. D., & Petrovitch, H. (2005) · Neurology · doi:10.1212/01.wnl.0000183056.89590.0d · Cited by 439 · see citing works
Comorbidity of the nonmotor symptoms of Parkinson's disease
Shulman, L. M., Taback, R. L., Bean, J. A., & Weiner, W. J. (2001) · Movement Disorders · doi:10.1002/mds.1099 · Cited by 417 · see citing works
The Occurrence of Depression in Parkinson's Disease
Tandberg, E. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550020087019 · Cited by 415 · see citing works
A comparison of clinical and pathological features of young‐ and old‐onset Parkinson's disease
Gibb, W. R. G., & Lees, A. J. (1988) · Neurology · doi:10.1212/wnl.38.9.1402 · Cited by 371 · see citing works
Fatigue in Parkinson's disease: A review
Friedman, J. H., Brown, R. G., Comella, C. L., Garber, C. E., Krupp, L., Lou, J., Marsh, L., Nail, L. M., Shulman, L. M., & Taylor, C. B. (2006) · Movement Disorders · doi:10.1002/mds.21240 · Cited by 356 · see citing works
Marsh, L., McDonald, W. M., Cummings, J. L., Ravina, B. M., & NINDS/NIMH Work Group on Depression and Parkinson's Disease (2005) · Movement Disorders · doi:10.1002/mds.20723 · Cited by 319 · see citing works
Dissociating apathy and depression in Parkinson disease
Kirsch‐Darrow, L., Fernandez, H. H., Marsiske, M., Okun, M. S., & Bowers, D. (2006) · Neurology · doi:10.1212/01.wnl.0000230572.07791.22 · Cited by 285 · see citing works
What contributes to depression in Parkinson's disease?
SCHRAG, A., JAHANSHAHI, M., & QUINN, N. P. (2001) · Psychological Medicine · doi:10.1017/s0033291799003141 · Cited by 242 · see citing works
Fatigue in Parkinson's disease
Friedman, J., & Friedman, H. (1993) · Neurology · doi:10.1212/wnl.43.10.2016 · Cited by 230 · see citing works
Pain and motor complications in Parkinson's disease
Tinazzi, M. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.079053 · Cited by 228 · see citing works
Direct economic impact of Parkinson's disease: A research survey in the United Kingdom
Findley, L. J. J., Aujla, M., Bain, P. G., Baker, M. G., Beech, C., Bowman, C., Holmes, J., Kingdom, W. K., MacMahon, D. G., Peto, V., et al. (2003) · Movement Disorders · doi:10.1002/mds.10507 · Cited by 227 · see citing works
Depression in classic versus akinetic‐rigid Parkinson's disease
STARKSTEIN, S. E., Petracca, G., Chemerinski, E., Tesón, A., Sabe, L., Merello, M., & Leiguarda, R. C. (1998) · Movement Disorders · doi:10.1002/mds.870130109 · Cited by 174 · see citing works
Quantitation of non‐motor symptoms in Parkinson’s disease
Chaudhuri, К. R., & Martínez‐Martín, P. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02212.x · Cited by 160 · see citing works
Diurnal effects of motor activity and fatigue in Parkinson's disease.
van Hilten, J. J., Hoogland, G., van der Velde, E. A., Middelkoop, H. A., Kerkhof, G. A., & Roos, R. A. (1993) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.8.874 · Cited by 105 · see citing works
Ahlskog, J. E. (2004) · Movement Disorders · doi:10.1002/mds.20362 · Cited by 83 · see citing works
The PRIAMO study: background, methods and recruitment
Antonini, A., Colosimo, C., Marconi, R., Morgante, L., & Barone, P. (2008) · Neurological Sciences · doi:10.1007/s10072-008-0863-z · Cited by 30 · see citing works
Self-citationCorrelation of Parkinson's disease severity and duration with123I-FP-CIT SPECT striatal uptake
Benamer, H. T. S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G. J. A., & Grosset, D. G. (2000) · Movement Disorders · doi:10.1002/1531-8257(200007)15:4
Flagged first, then by citations
Cited by
Sorted by citations
Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy
Kluger, B. M., Krupp, L. B., & Enoka, R. M. (2013) · Neurology · doi:10.1212/wnl.0b013e31827f07be · Cited by 1,036 · see citing works
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Prediagnostic presentations of Parkinson’s disease in primary care: A case-control study
Schrag, A., Horsfall, L., Walters, K., Noyce, A., & Petersen, I. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70287-x · Cited by 674 · see citing works
The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588 · see citing works
Sleep and Circadian Rhythm Regulation in Early Parkinson Disease
Breen, D. P., Vuono, R., Nawarathna, U., Fisher, K., Shneerson, J. M., Reddy, A. B., & Barker, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.65 · Cited by 440 · see citing works
Quantitative wearable sensors for objective assessment of Parkinson's disease
Maetzler, W., Domingos, J., Srulijes, K., Ferreira, J. J., & Bloem, B. R. (2013) · Movement Disorders · doi:10.1002/mds.25628 · Cited by 374 · see citing works
Circadian Rhythms, Sleep, and Disorders of Aging
Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369 · see citing works
Cersosimo, M. G., Raina, G. B., Pecci, C., Pellene, A., Calandra, C. R., Gutiérrez, C., Micheli, F. E., & Benarroch, E. E. (2013) · Journal of Neurology · doi:10.1007/s00415-012-6801-2 · Cited by 314 · see citing works
Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis
Chen, H., Zhao, E. J., Zhang, W., Lu, Y., Liu, R., Huang, X., Ciesielski-Jones, A. J., Justice, M. A., Cousins, D. S., & Peddada, S. (2015) · Translational Neurodegeneration · doi:10.1186/2047-9158-4-1 · Cited by 212 · see citing works
Psychosis, apathy, depression and anxiety in Parkinson's disease
Gallagher, D. A., & Schrag, A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.041 · Cited by 211 · see citing works
Many faces of Parkinson's disease: non-motor symptoms of Parkinson's disease
Lee, H. M., & Koh, S.-B. (2015) · Journal of Movement Disorders · doi:10.14802/jmd.15003 · Cited by 191 · see citing works
Prevalence of small intestinal bacterial overgrowth in Parkinson’s disease
Gabrielli, M., Bonazzi, P., Scarpellini, E., Bendia, E., Lauritano, E. C., Fasano, A., Ceravolo, M. G., Capecci, M., Rita Bentivoglio, A., Provinciali, L., et al. (2011) · Movement Disorders · doi:10.1002/mds.23566 · Cited by 175 · see citing works
The importance of non-motor disturbances to quality of life in Parkinson's disease
Martinez-Martin, P. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.05.006 · Cited by 160 · see citing works
New methods for the assessment of Parkinson's disease (2005 to 2015): A systematic review
Sánchez‐Ferro, Á., Elshehabi, M., Godinho, C., Salkovic, D., Hobert, M. A., Domingos, J., van Uem, J. M., Ferreira, J. J., & Maetzler, W. (2016) · Movement Disorders · doi:10.1002/mds.26723 · Cited by 145 · see citing works
Georgescu, D., Ancusa, O., Georgescu, L., Ionita, I., & Reisz, D. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s106284 · Cited by 138 · see citing works
Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?
Hinnell, C., Hurt, C. S., Landau, S., Brown, R. G., Samuel, M., & on behalf of the PROMS‐PD Study Group (2012) · Movement Disorders · doi:10.1002/mds.23961 · Cited by 142 · see citing works
Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease
Bolitho, S. J., Naismith, S. L., Rajaratnam, S. M. W., Grunstein, R. R., Hodges, J. R., Terpening, Z., Rogers, N., & Lewis, S. J. G. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.10.016 · Cited by 139 · see citing works
Neuropsychiatric symptoms, behavioural disorders, and quality of life in Parkinson's disease
Balestrino, R., & Martinez-Martin, P. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.12.060 · Cited by 135 · see citing works
Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments
Poirier, A.-A., Aubé, B., Côté, M., Morin, N., Di Paolo, T., & Soulet, D. (2016) · Parkinson s Disease · doi:10.1155/2016/6762528 · Cited by 130 · see citing works
Metta, V., Leta, V., Mrudula, K. R., Prashanth, L. K., Goyal, V., Borgohain, R., Chung-Faye, G., & Chaudhuri, K. R. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10567-w · Cited by 130 · see citing works
Advocat, J., Enticott, J., Vandenberg, B., Hassed, C., Hester, J., & Russell, G. (2016) · BMC Neurology · doi:10.1186/s12883-016-0685-1 · Cited by 94 · see citing works
Actigraphy for the Assessment of Sleep Measures in Parkinson's Disease
Maglione, J. E., Liu, L., Neikrug, A. B., Poon, T., Natarajan, L., Calderon, J., Avanzino, J. A., Corey-Bloom, J., Palmer, B. W., Loredo, J. S., et al. (2013) · Sleep · doi:10.5665/sleep.2888 · Cited by 84 · see citing works
The potential prognostic role of cardiovascular autonomic failure in α‐synucleinopathies
Fanciulli, A., Strano, S., Colosimo, C., Caltagirone, C., Spalletta, G., & Pontieri, F. E. (2013) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03819.x · Cited by 77 · see citing works
Self-citationGastrointestinal features of Parkinson’s disease
Cloud, L. J., & Greene, J. G. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0204-0 · Cited by 67 · see citing works
Gelauff, J. M., Kingma, E. M., Kalkman, J. S., Bezemer, R., van Engelen, B. G. M., Stone, J., Tijssen, M. A. J., & Rosmalen, J. G. M. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8915-7 · Cited by 67 · see citing works
Fanciulli, A., Strano, S., Ndayisaba, J. P., Goebel, G., Gioffrè, L., Rizzo, M., Colosimo, C., Caltagirone, C., Poewe, W., Wenning, G. K., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7339-2 · Cited by 67 · see citing works
Self-citationPrevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson's disease
Niu, X.-L., Liu, L., Song, Z.-X., Li, Q., Wang, Z.-H., Zhang, J.-L., & Li, H.-H. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1612-8 · Cited by 64 · see citing works
Mills, K. A., Greene, M. C., Dezube, R., Goodson, C., Karmarkar, T., & Pontone, G. M. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4834 · Cited by 63 · see citing works
Kwok, J. Y. Y., Kwan, J. C. Y., Auyeung, M., Mok, V. C. T., & Chan, H. Y. L. (2017) · Trials · doi:10.1186/s13063-017-2223-x · Cited by 56 · see citing works
Ghielen, I., van Wegen, E. E. H., Rutten, S., de Goede, C. J. T., Houniet-de Gier, M., Collette, E. H., Burgers-Bots, I. A. L., Twisk, J. W. R., Kwakkel, G., Vermunt, K., et al. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.09.008 · Cited by 50 · see citing works
Kong, K. H., Ng, H. L., Li, W., Ng, D. W., Tan, S. I., Tay, K. Y., Au, W. L., & Tan, L. C. S. (2018) · Brain and Behavior · doi:10.1002/brb3.897 · Cited by 48 · see citing works
Cognitive behavioral therapy for insomnia in Parkinson’s disease: a case series
Humbert, M., Findley, J., Hernandez-Con, M., & Chahine, L. M. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-017-0027-z · Cited by 39 · see citing works
Rocchi, C., Pierantozzi, M., Galati, S., Chiaravalloti, A., Pisani, V., Prosperetti, C., Lauretti, B., Stampanoni Bassi, M., Olivola, E., Schillaci, O., et al. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12437 · Cited by 31 · see citing works
Fifel, K., Piggins, H., & Deboer, T. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.02.005 · Cited by 30 · see citing works
“Pseudo-syndromes” associated with Parkinson disease, dementia, apathy, anxiety, and depression
Weiss, H. D., & Pontone, G. M. (2019) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000644 · Cited by 21 · see citing works
Non-motor symptoms in Parkinson's disease
Barbosa, E. R. (2013) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20130001 · Cited by 21 · see citing works
Mindfulness based stress reduction in people with Parkinson's disease and their care partners
Shah-Zamora, D., Allen, A. M., Rardin, L., Ivancic, M., Durham, K., Hickey, P., Cooney, J. W., Scott, B. L., & Mantri, S. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101377 · Cited by 19 · see citing works
What is the lived experience of anxiety for people with Parkinson’s? A phenomenological study
Lovegrove, C. J., & Bannigan, K. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249390 · Cited by 15 · see citing works
- Authors
- Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, R. M., Iemolo, F., Manfredi, M., Meco, G., Nicoletti, A., Pederzoli, M., Petrone, A., Pisani, A., Pontieri, F. E., Quatrale, R., Ramat, S., Scala, R., Volpe, G., Zappulla, S., Bentivoglio, A. R., Stocchi, F., Trianni, G., & Dotto, P. D.
- Affiliations
- University of Naples Federico II (IT)
- Istituti Clinici di Perfezionamento (IT)
- Sapienza University of Rome (IT)
- Ospedale Misericordia - Grosseto (IT)
- University of Messina (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- University of Ragusa (IT)
- Fondazione Salvatore Maugeri (IT)
- Policlinico Universitario di Catania (IT)
- Ospedale Annunziata di Cosenza (IT)
- Policlinico Tor Vergata (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- Arcispedale Sant'Anna (IT)
- Ospedale Santa Maria di Loreto Nuovo (IT)
- Azienda Sanitaria Locale Salerno (IT)
- Instituto de Neurologia de Curitiba (BR)
- Università Cattolica del Sacro Cuore (IT)
- IRCCS San Raffaele Roma (IT)
- Ospedale Versilia (IT)
- Corresponding author
- Antonini, Angelo
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2009-06-09
- Volume
- 24
- Issue
- 11
- Pages
- 1641-1649
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2166211493
- Cited by
- 1,445
- References
- 36
- Citations by year
- 2026: 55 · 2025: 81 · 2024: 95 · 2023: 99 · 2022: 107 · 2021: 110 · 2020: 97 · 2019: 105 · 2018: 87 · 2017: 114 · 2016: 109 · 2015: 95 · 2014: 73 · 2013: 74 · 2012: 59
- FWCI
- 30.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, non-motor symptoms, quality of life, fatigue, anxiety, apathy, cognitive impairment, insomnia, leg pain, drooling, attention and memory deficits, disease duration, PDQ-39, symptom prevalence
- MeSH terms
- Aged, Olfaction Disorders, Antiparkinson Agents, Anxiety, Cognition Disorders, Depression, Fatigue, Female, Gastrointestinal Diseases, Humans, Italy, Male, Middle Aged, Pain, Parkinson Disease, Quality of Life, Urination Disorders, Sleep Disorders, Intrinsic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
