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How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: Comparison with the unified Parkinson's disease rating scale

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Stebbins, Glenn T., Goetz, Christopher G., Burn, David J., Jankovic, Joseph, Khoo, Tien K., Tilley, Barbara C.·2013·Movement Disorders

Abstract

Background: Formulas were developed to define tremor dominant (TD) and postural instability/gait difficulty (PIGD) phenotypes of Parkinson's Disease (PD) using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS). TD and PIGD designations, based on the original Unified Parkinson's Disease Rating Scale (UPDRS), provided useful designations for classifying different phenotypes of PD. With the advent of the MDS‐UPDRS, a valid set of calculations for these phenotypes is needed. Methods: UPDRS and MDS‐UPDRS scores were collected on 877 PD patients. TD/PIGD scores were calculated using the UPDRS formula for all patients. Comparable TD and PIGD items from the MDS‐UPDRS were used to calculate new ratios. Data were analyzed using receiver operating characteristic models. Results: The new MDS‐UPDRS TD/PIGD ratios accounted for a significant area under the curve compared with the UPDRS classification. Optimal sensitivity and specificity were obtained with MDS‐UPDRS cutoff scores of ≥1.15 for TD classification and ≤0.90 for PIGD. Conclusions: The development of comparable and valid PIGD and TD scores from the MDS‐UPDRS provides a clear method for clinicians and researchers to transition from the original UPDRS to the new MDS‐UPDRS in categorizing patients with different clinical phenotypes. © 2013 Movement Disorder Society

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Metadata

Authors
Stebbins, G. T., Goetz, C. G., Burn, D. J., Jankovic, J., Khoo, T. K., & Tilley, B. C.
Venue
Movement Disorders
Publisher
Wiley
Published
2013-02-13
Volume
28
Issue
5
Pages
668-670
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
OpenAlex
W2019182054
Cited by
932
References
14
FWCI
15.20
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: Comparison with the unified Parkinson's disease rating scale. https://app.cochat.ai/papers/10.1002/mds.25383
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Stebbins, G. T., Goetz, C. G., Burn, D. J., Jankovic, J., Khoo, T. K., & Tilley, B. C. (2013). How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: Comparison with the unified Parkinson's disease rating scale. Movement Disorders. https://doi.org/10.1002/mds.25383

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