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Genetic variability of the retromer cargo recognition complex in parkinsonism

Gustavsson, Emil K., Guella, Ilaria, Trinh, Joanne, Szu‐Tu, Chelsea, Rajput, Alex, Rajput, Ali H., Steele, John C., McKeown, Martin, Jeon, Beom S., Aasly, Jan O., Farrer, Matthew J.·2015·Movement Disorders
DOI 10.1002/mds.26104
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Abstract

Background: A pathogenic mutation (VPS35 p.D620N) within the retromer complex has been shown to segregate with late‐onset Parkinson's disease (PD). Several studies have subsequently detected the mutation in patients with PD and not in controls. Methods: Mutation screening of the coding regions of the retromer cargo recognition complex genes ( VPS26A/B , VPS29 , and VPS35 ) was carried out in patients with PD (n = 396), atypical parkinsonism (n = 229), and in 368 controls. Results: Overall, we identified five rare nonsynonymous mutations in VPS26A and one in VPS35 ; none were observed in VPS26B or VPS29 . Three VPS26A variants (p.K93E, p.M112V, and p.K297X), identified in patients with atypical parkinsonism, were not observed in controls from this study (n = 368) or from publically available data sets (n = 4,426). Conclusion: Our results support the hypothesis that rare variants in the retromer complex genes may be involved in the development of parkinsonism, although further studies are warranted before any solid conclusions can be drawn. © 2014 International Parkinson and Movement Disorder Society

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  • Genetic studies have identified many genes associated with the endosomal network as causal for neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis.

    “Genetic studies have identified many genes associated with the endosomal network to be causal for numerous neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis [1][2][3][4][5][6][7].”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [4]

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Research works printed but not linked: 27

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Metadata

Authors
Gustavsson, E. K., Guella, I., Trinh, J., Szu‐Tu, C., Rajput, A., Rajput, A. H., Steele, J. C., McKeown, M., Jeon, B. S., Aasly, J. O., & Farrer, M. J.
Venue
Movement Disorders
Publisher
Wiley
Published
2014-12-05
Volume
30
Issue
4
Pages
580-584
ISSN
  • 0885-3185
  • 1531-8257
DOI
10.1002/mds.26104
Cited by
29
References
0
Language
en
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