Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy
Open accessAbstract
One of the most common neuropsychiatric symptoms in Parkinson's disease (PD) is apathy, affecting between 23% and 70% of patients and thought to be related to frontostriatal dopamine deficits. In the current study, we assessed functional resting-state frontostriatal connectivity and structural changes associated with the presence of apathy in a large sample of PD subjects and healthy controls, while controlling for the presence of comorbid depression and cognitive decline. Thirty-one healthy controls (HC) and 62 age-, sex-, and education-matched PD patients underwent resting-state functional magnetic resonance imaging (MRI). Apathy symptoms were evaluated with the Apathy Scale (AS). The 11 Beck Depression Inventory-II items that measure dysphoric mood symptoms as well as relevant neuropsychological scores were used as nuisance factors in connectivity analyses. Voxel-wise analyses of functional connectivity between frontal lobes (limbic, executive, rostral motor, and caudal motor regions), striata (limbic, executive, sensorimotor regions), and thalami were performed. Subcortical volumetry/shape analysis and fronto-subcortical voxel-based morphometry were performed to assess associated structural changes. Twenty-five PD patients were classified as apathetic (AS > 13). Apathetic PD patients showed functional connectivity reductions compared with HC and with non-apathetic patients, mainly in left-sided circuits, and predominantly involving limbic striatal and frontal territories. Similarly, severity of apathy negatively correlated with connectivity in these circuits. No significant effects were found in structural analyses. Our results indicate that the presence of apathy in PD is associated with functional connectivity reductions in frontostriatal circuits, predominating in the left hemisphere and mainly involving its limbic components.
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Apathy in Alzheimer's disease is associated with reduced connectivity in left-sided circuits, predominantly involving limbic striatal and frontal territories.
“A study of resting-state connectivity using functional MRI (fMRI) reported an association of apathy with reduced connectivity in left-sided circuits, predominantly involving limbic striatal and frontal territories (Baggio et al., 2015).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Baggio et al., 2015
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- Authors
- Baggio, H. C., Segura, B., Garrido‐Millan, J. L., Marti, M., Compta, Y., Valldeoriola, F., Tolosa, E., & Junque, C.
- Affiliations
- Departament de Psiquiatria i Psicobiologia Clínica Universitat de Barcelona. Barcelona Catalonia Spain
- Universitat de Barcelona (ES)
- Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Barcelona Catalonia Spain
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2015-01-20
- Volume
- 30
- Issue
- 5
- Pages
- 671-679
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W1912463275
- Cited by
- 131
- References
- 44
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 10 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 18 · 2016: 13 · 2015: 5
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, apathy, resting-state functional connectivity, frontostriatal circuits, limbic striatum, thalamus, comorbid depression, cognitive decline, voxel-based morphometry, Apathy Scale
- MeSH terms
- Aged, Corpus Striatum, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Oxygen, Parkinson Disease, Rest, Apathy, White Matter
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