The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
Abstract
Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing blood stasis) herb with 1000 years of clinical application. It mainly contains two groups of ingredients: the hydrophilic phenolic acids and the lipophilic tanshinones. Both groups have demonstrated multiple bioactivities, such as antioxidative stress, antiplatelet aggregation, anti‐inflammation, among others. Recent data have demonstrated that its lipophilic compounds, especially the tanshinones, show potent anticancer activities both in vitro and in vivo. The anticancer effects of the hydrophilic phenolic acids have also been reported. Furthermore, tanshinones provide structural skeletons for chemical modifications, allowing for a series of derivatives of interests. This review provides a systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones, aiming to bring new insights for further research and development of this ancient herb.
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Cites
Apoptosis in cancer: from pathogenesis to treatment
Wong, R. S. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-87 · Cited by 2,836
Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use
Zhou, L., Zuo, Z., & Chow, M. S. S. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005282630 · Cited by 1,274
Cardiovascular effects of Danshen
Cheng, T. O. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.01.004 · Cited by 439
A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs
Sun, Y., Xun, K., Wang, Y., & Chen, X. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328330d95b · Cited by 417
Self-citationCardiovascular actions and therapeutic potential of tanshinone IIA
Gao, S., Liu, Z., Li, H., Little, P. J., Liu, P., & Xu, S. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.041 · Cited by 359
Shin, D.-S., Kim, H.-N., Shin, K. D., Yoon, Y. J., Kim, S.-J., Han, D. C., & Kwon, B.-M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2575 · Cited by 309
Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection
Ho, J., & Hong, C.-Y. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-30 · Cited by 292
Potential anticancer activity of tanshinone IIA against human breast cancer
Wang, X., Wei, Y., Yuan, S., Liu, G., Lu, Y., Zhang, J., & Wang, W. (2005) · International Journal of Cancer · doi:10.1002/ijc.20880 · Cited by 237
Dong, Y., Morris-Natschke, S. L., & Lee, K.-H. (2011) · Natural Product Reports · doi:10.1039/c0np00035c · Cited by 228
Epigenetic regulation and cancer (Review)
CHEN, Q. W., Zhu, X., Li, Y., & Meng, Z. (2013) · Oncology Reports · doi:10.3892/or.2013.2913 · Cited by 168
Cited by
Chen, L., Yang, Q., Zhang, H., Wan, L., Xin, B., Cao, Y., Zhang, J., & Guo, C. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113066 · Cited by 39
Recent advances of tanshinone in regulating autophagy for medicinal research
Wu, S., Zhao, K., Wang, J., Liu, N., Nie, K., Qi, L., & Xia, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1059360 · Cited by 32
Kim, N. Y., Jung, Y. Y., Yang, M. H., Chinnathambi, A., Govindasamy, C., Narula, A. S., Namjoshi, O. A., Blough, B. E., & Ahn, K. S. (2022) · Biochimie · doi:10.1016/j.biochi.2022.05.018 · Cited by 24
Metadata
- Authors
- Chen, X., Guo, J., Bao, J., Lu, J., & Wang, Y.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2013-10-07
- Volume
- 34
- Issue
- 4
- Pages
- 768-794
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W1821806054
- Cited by
- 279
- References
- 80
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, X., Guo, J., Bao, J., Lu, J., & Wang, Y. (2014). The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review. Medicinal Research Reviews. https://doi.org/10.1002/med.21304
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