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Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents
Abstract
Tanshinones are a series of abietane diterpenes, isolated exclusively from Salvia miltiorrhiza and related species. More than 40 tanshinones and their analogs have been isolated since the 1930s. Their biosynthetic pathway correlates with the MEP/DOXP pathway, and many key enzymes, such as mCPS, are responsible for establishing their molecular scaffolds and stereospecificity. Because of their unique structural characteristics and promising biological activities, total syntheses of various tanshinones have attracted the interest of many synthetic chemists, including R. H. Thomson, H. Kakisawa, R. L. Danheiser, Y. Inouye and J. K. Snyder. Tanshinones and their analogs exhibit interesting and broad antitumor activity in various cell and animal models. Most recently, the tanshinone analog neo-tanshinlactone has shown potent and selective activity against breast cancer. This review will discuss the biosynthesis, total syntheses, and antitumor activities of tanshinones,especially neo-tanshinlactone and its analogs.
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Cited by
The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
Chen, X., Guo, J., Bao, J., Lu, J., & Wang, Y. (2014) · Medicinal Research Reviews · doi:10.1002/med.21304 · Cited by 279
A New Concept on Quality Marker for Quality Assessment and Process Control of Chinese Medicines
Liu, C.-X., Cheng, Y.-Y., Guo, D.-A., Zhang, T.-J., Li, Y.-Z., Hou, W.-B., Huang, L.-Q., & Xu, H.-Y. (2017) · Chinese Herbal Medicines · doi:10.1016/s1674-6384(17)60070-4 · Cited by 128
Wang, M., Wang, J., Zhang, Y., Xia, Q., Bi, W., Yang, X., & Chen, D. D. Y. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.03.061 · Cited by 108
Metadata
- Authors
- Dong, Y., Morris-Natschke, S. L., & Lee, K.-H.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 28
- Issue
- 3
- Pages
- 529
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2031461934
- Cited by
- 228
- References
- 0
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dong, Y., Morris-Natschke, S. L., & Lee, K.-H. (2011). Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Natural Product Reports. https://doi.org/10.1039/c0np00035c
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