The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Anthraquinones As Pharmacological Tools and Drugs
Abstract
Anthraquinones (9,10‐dioxoanthracenes) constitute an important class of natural and synthetic compounds with a wide range of applications. Besides their utilization as colorants, anthraquinone derivatives have been used since centuries for medical applications, for example, as laxatives and antimicrobial and antiinflammatory agents. Current therapeutic indications include constipation, arthritis, multiple sclerosis, and cancer. Moreover, biologically active anthraquinones derived from Reactive Blue 2 have been utilized as valuable tool compounds for biochemical and pharmacological studies. They may serve as lead structures for the development of future drugs. However, the presence of the quinone moiety in the structure of anthraquinones raises safety concerns, and anthraquinone laxatives have therefore been under critical reassessment. This review article provides an overview of the chemistry, biology, and toxicology of anthraquinones focusing on their application as drugs.
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Cited by
Are Senna based laxatives safe when used as long term treatment for constipation in children?
Vilanova-Sanchez, A., Gasior, A. C., Toocheck, N., Weaver, L., Wood, R. J., Reck, C. A., Wagner, A., Hoover, E., Gagnon, R., Jaggers, J., et al. (2018) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2018.01.002 · Cited by 89
Metadata
- Authors
- Malik, E. M., & Müller, C. E.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2016-04-25
- Volume
- 36
- Issue
- 4
- Pages
- 705-748
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2342812346
- Cited by
- 448
- References
- 163
- FWCI
- 34.61
- Type
- journal article
- Language
- en
- Open access
- closed
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