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The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration
Abstract
A method is described for measuring glomerular permeability by dextran clearance using Sephadex gel filtration technique. Clearance is shown to be a function of molecular size, decreasing with increasing molecular weight. At a mol. weight higher than 55,000, the clearance is very low and approximately zero, while it averages 95 ml per minute at a mol. weight of 15,000. If plotted in a log.log. graph, a linear relation is found between clearance and molecular weight. In a semilog. graph, however, with clearance plotted against log. Stokes radius, the relation is also linear, with a slight deflection in the high molecular part, however.
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Citations
Cited by
Setsukinai, K.-I., Urano, Y., Kakinuma, K., Majima, H. J., & Nagano, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209264200 · Cited by 1,301
Sørensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., & Borregaard, N. (2001) · Blood · doi:10.1182/blood.v97.12.3951 · Cited by 894
Flier, J. S., Kahn, C. R., Roth, J., & Bar, R. S. (1975) · Science · doi:10.1126/science.170678 · Cited by 438
Rebelatto, C. K., Aguiar, A. M., Moretão, M. P., Senegaglia, A. C., Hansen, P., Barchiki, F., Oliveira, J., Martins, J., Kuligovski, C., Mansur, F., et al. (2008) · Experimental Biology and Medicine · doi:10.3181/0712-rm-356 · Cited by 429
Yamamoto, N., Okada, M., Koyanagi, Y., Kannagi, M., & Hinuma, Y. (1982) · Science · doi:10.1126/science.6980467 · Cited by 398
Metadata
- Authors
- Mogensen, C. E.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1968-01
- Volume
- 21
- Issue
- 1
- Pages
- 77-82
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W1974148619
- Cited by
- 2,654
- References
- 0
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mogensen, C. E. (1968). The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration. Scandinavian Journal of Clinical and Laboratory Investigation. https://doi.org/10.3109/00365516809076979
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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