Small molecules regulating reactive oxygen species homeostasis for cancer therapy

Zhang, Junmin, Duan, Dongzhu, Song, Zi‐Long, Liu, Tianyu, Hou, Yanan, Fang, Jianguo·2021·Medicinal Research Reviews

Cites (439)

Items 201–400 of 433

  1. Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells
    Dong Xiao, Anna A. Powolny, Michelle Barbi de Moura, Eric E. Kelley, Ajay Bommareddy, Su‐Hyeong Kim, Eun‐Ryeong Hahm, Daniel Paul Normolle, Bennett Van Houten, Shivendra Vikram Singh · 2010 · Journal of Biological Chemistry
  2. Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells
    Dongzhu Duan, Baoxin Zhang, Juan Yao, Yaping Liu, Jianguo Fang · 2014 · Free Radical Biology and Medicine
  3. Redox regulation of cancer cell migration and invasion.
    L. Tochhawng, Shuo Deng, S. Pervaiz, C. Yap · 2013 · Mitochondrion (Amsterdam. Print)
  4. Rapid Induction of Cell Death by Selenium-compromised Thioredoxin Reductase 1 but Not by the Fully Active Enzyme Containing Selenocysteine
    Karin Anestål, Elias S.J. Arnér · 2003 · Journal of Biological Chemistry
  5. Artemisinin, a miracle of traditional Chinese medicine
    Ling Yi Kong, Ren Xiang Tan · 2015 · Natural Product Reports
  6. Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
    Junmin Zhang, Baoxin Zhang, Xinming Li, Xiao Han, Ruijuan Liu, Jianguo Fang · 2018 · Medicinal Research Reviews
  7. Inhibition of oxidative stress in HeLa cells by chemopreventive agents.
    Ramesh S. Bhimani, Walter Troll, Dezider Grünberger, Krystyna Frenkel · 1993 · PubMed
  8. Motexafin gadolinium: A novel redox active drug for cancer therapy
    Darren J. Magda, Richard A. Miller · 2006 · Seminars in Cancer Biology
  9. Targeting Metabolic–Redox Circuits for Cancer Therapy
    Kui Wang, Jingwen Jiang, Yunlong Lei, Shengtao Zhou, Yuquan Wei, Canhua Huang · 2019 · Trends in Biochemical Sciences
  10. From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate
    Toren Finkel · 2012 · Science Signaling
  11. Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment
    Moon, Eui Jung, Giaccia, Amato · 2015 · Free Radical Biology and Medicine
  12. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
    Xupeng Bai, Yibei Chen, Xiangyu Hou, Min Huang, Jing Jin · 2016 · Drug Metabolism Reviews
  13. Development of Cancer Chemopreventive Agents: Oltipraz as a Paradigm
    Thomas W. Kensler, John D. Groopman, Thomas R. Sutter, Thomas J. Curphey, Bill D. Roebuck · 1999 · Chemical Research in Toxicology
  14. Molecular mechanisms for the anti-cancer effects of diallyl disulfide
    Lan Yi, Qi Su · 2013 · Food and Chemical Toxicology
  15. c-Jun NH2-Terminal Kinase Signaling Axis Regulates Diallyl Trisulfide–Induced Generation of Reactive Oxygen Species and Cell Cycle Arrest in Human Prostate Cancer Cells
    Jędrzej Antosiewicz, Anna Herman-Antosiewicz, Stanley W. Marynowski, Shivendra Vikram Singh · 2006 · Cancer Research
  16. Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of γ-glutamyl transpeptidase-dependent H2O2 production and S-thiolation
    Silvia Dominici, Melissa Valentini, Emilia Maellaro, Barbara Del Bello, Aldo Paolicchi, Evelina Lorenzini, Roberto Tongiani, Mario Comporti, Alfonso Pompella C · 1999 · Free Radical Biology and Medicine
  17. Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways
    Bhupendra Singh, Rivka L. Shoulson, Anwesha Chatterjee, Amruta Mukund Ronghe, Nimee K. Bhat, Daniel C. Dim, Hari K. Bhat · 2014 · Carcinogenesis
  18. Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.
    K Handa, Shojiro Sato · 1975 · PubMed
  19. Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells
    Arabinda Das, Naren Lal Banik, Swapan K. Ray · 2007 · Cancer
  20. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction
    Muhammad Noman Khan, Fei Yi, Azhar Rasul, Ting Li, Nan Wang, Hongwen Gao, Rong Gao, Tonghui Ma · 2012 · IUBMB Life
  21. Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell Extracts
    Yonit Kasherman, Stefan Stürup, Dan Gibson · 2009 · Journal of Medicinal Chemistry
  22. Capsaicin-induced apoptosis in human hepatoma HepG2 cells.
    Shang-Pang Huang, Jung‐Chou Chen, Chih‐Chung Wu, Chi-Tsai Chen, Nou-Ying Tang, Yung-Tsuan Ho, Chyi Lo, Jink-Pin Lin, Jing‐Gung Chung, Jaung-Geng Lin · 2009 · PubMed
  23. Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity
    Nuno Martinho, Tânia C.B. Santos, Helena F. Florindo, Liana C. Silva · 2019 · Frontiers in Physiology
  24. Role of Reactive Oxygen Species-Mediated Signaling in Aging
    Vyacheslav M. Labunskyy, Vadim N. Gladyshev · 2012 · Antioxidants and Redox Signaling
  25. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
    Judith van Asperen, Olaf van Tellingen, Frank Tijssen, Alfred H. Schinkel, Jos H. Beijnen · 1998 · British Journal of Cancer
  26. Redox Regulation of Multidrug Resistance in Cancer Chemotherapy: Molecular Mechanisms and Therapeutic Opportunities
    Macus Tien Kuo · 2008 · Antioxidants and Redox Signaling
  27. Vitamin A, Cancer Treatment and Prevention: The New Role of Cellular Retinol Binding Proteins
    Elena Doldo, Gaetana Costanza, Sara Agostinelli, Chiara Tarquini, Amedeo Ferlosio, Gaetano Arcuri, Daniela Passeri, Maria Giovanna Scioli, Augusto Orlandi · 2015 · BioMed Research International
  28. Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide
    Lillig, Christopher Horst, Lönn, Maria Elisabet, Enoksson, Mari, Fernandes, Aristi Potamitou, Holmgren, Arne · 2004 · Proceedings of the National Academy of Sciences
  29. Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer
    Luksana Chaiswing, William H. St. Clair, Daret K. St. Clair · 2018 · Antioxidants and Redox Signaling
  30. Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism
    Garrido-Urbani, Sarah, Jemelin, Stephane, Deffert, Christine, Carnesecchi, Stéphanie, Basset, Olivier, Szyndralewiez, Cédric, Heitz, Freddy, Page, Patrick, Montet, Xavier, Michalik, Liliane et al. · 2011 · PLoS ONE
  31. Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies
    Azadeh Manayi, Seyed Mohammad Nabavi, William N. Setzer, Samineh Jafari · 2017 · Current Medicinal Chemistry
  32. Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase
    Dongzhu Duan, Baoxin Zhang, Juan Yao, Yaping Liu, Jinyu Sun, Chunpo Ge, Shoujiao Peng, Jianguo Fang · 2014 · Free Radical Biology and Medicine
  33. Glutathione disulfide induces apoptosis in U937 cells by a redox‐mediated p38 mitogen‐activated protein kinase pathway
    Giuseppe Filomeni, Giuseppe Rotilio, Maria Rosa Ciriolo · 2002 · The FASEB Journal
  34. Mechanisms of Inhibition of the Thioredoxin Growth Factor System by Antitumor 2-Imidazolyl Disulfides
    D. Lynn Kirkpatrick, Miles Kuperus, Marla Dowdeswell, Noëlle Potier, Lynda J. Donald, Mark W. Kunkel, Margareta I. Berggren, Miguel Angulo, Garth Powis · 1998 · Biochemical Pharmacology
  35. Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
    Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki · 2015 · Journal of Clinical Biochemistry and Nutrition
  36. Arsenic trioxide: insights into its evolution to an anticancer agent
    Maneka Hoonjan, Vaibhav Jadhav, Purvi Bhatt · 2018 · JBIC Journal of Biological Inorganic Chemistry
  37. Potential Anticancer Activity of Auranofin
    Takefumi Onodera, Isao Momose, Manabu Kawada · 2019 · Chemical and Pharmaceutical Bulletin
  38. Quinone Methide Derivatives: Important Intermediates to DNA Alkylating and DNA Cross-linking Actions
    Ping Wang, Yang Song, Lixia Zhang, Hanping He, Xiang Zhou · 2005 · Current Medicinal Chemistry
  39. Different antitumor effects of quercetin, quercetin-3′-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells
    Qiu Wu, Paul W. Needs, Yalong Lu, Paul Antony Kroon, Daoyuan Ren, Xingbin Yang · 2018 · Food & Function
  40. Selenium induces a multi‐targeted cell death process in addition to ROS formation
    Marita Wallenberg, Sougat Misra, Agata Magdalena Wasik, Cristina Marzano, Mikael Björnstedt, Valentina Gandin, Aristi Potamitou Fernandes · 2014 · Journal of Cellular and Molecular Medicine
  41. Dithiaarsanes Induce Oxidative Stress-Mediated Apoptosis in HL-60 Cells by Selectively Targeting Thioredoxin Reductase
    Yaping Liu, Dongzhu Duan, Juan Yao, Baoxin Zhang, Shoujiao Peng, Huilong Ma, Yanlin Song, Jianguo Fang · 2014 · Journal of Medicinal Chemistry
  42. Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone
    Yaxian Ding, Zi‐Jiang Chen, Shiguo Liu, Danian Che, Michael L. Vetter, Chung‐Ho Chang · 2004 · Journal of Pharmacy and Pharmacology
  43. Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization
    Anita Thyagarajan‐Sahu, Ravi P. Sahu · 2017 · Integrative Cancer Therapies
  44. Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants
    Haseeb Zubair, Husain Yar Khan, A Sohail, Shafquat Azim, Mohammad Fahad Ullah, Aamir Ahmad, Fazlul H. Sarkar, S.M. Hadi · 2013 · Cell Death and Disease
  45. Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins
    Yuee Cai, Jinming Zhang, Nelson G. Chen, Zhi Shi, Jian-Ge Qiu, Chengwei He, Meiwan Chen · 2016 · Medicinal Research Reviews
  46. A Phase I/II Study of Arsenic Trioxide/Bortezomib/Ascorbic Acid Combination Therapy for the Treatment of Relapsed or Refractory Multiple Myeloma
    James R. Berenson, Jeffrey Matous, Regina A. Swift, Russell Mapes, Blake Morrison, Howard Yeh · 2007 · Clinical Cancer Research
  47. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells
    Dongzhu Duan, Junmin Zhang, Juan Yao, Yaping Liu, Jianguo Fang · 2016 · Journal of Biological Chemistry
  48. A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination
    Ramanathan, Ramesh K., Abbruzzese, James, Dragovich, Tomislav, Kirkpatrick, Lynn, Guillen, Jose M., Baker, Amanda F., Pestano, Linda A., Green, Sylvan, Von Hoff, Daniel D. · 2011 · Cancer Chemotherapy and Pharmacology
  49. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo
    Brianna Cote, Lisa Janssen Carlson, Deepa A. Rao, Adam W. G. Alani · 2015 · Journal of Controlled Release
  50. Capsaicin Induces Heme Oxygenase-1 Expression in HepG2 Cells Via Activation of PI3K-Nrf2 Signaling: NAD(P)H:Quinone Oxidoreductase as a Potential Target
    Eun-Joo Joung, Meihua Li, Hee Geum Lee, Nuntiya Somparn, Young Suk Jung, Hye‐Kyung Na, Sung‐Hoon Kim, Young‐Nam Cha, Young‐Joon Surh · 2007 · Antioxidants and Redox Signaling
  51. Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis.
    Tetsuo Kimoto, M Aga, K Hino, Satomi Koya‐Miyata, Yoshio Yamamoto, Mark J Micallef, T Hanaya, S Arai, M Ikeda, Masashi Kurimoto · 2001 · PubMed
  52. The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
    Sheetal Panday, Raghav Talreja, Mahendra Kavdia · 2020 · Microvascular Research
  53. Phase I Clinical Trial of STA-4783 in Combination with Paclitaxel in Patients with Refractory Solid Tumors
    Anna Berkenblit, Joseph P. Eder, David P. Ryan, Michael V. Seiden, Noriaki Tatsuta, Matthew Leigh Sherman, Thomas A. Dahl, Bruce Jeffrey Dezube, Jeffrey G. Supko · 2007 · Clinical Cancer Research
  54. Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells
    Wenqing Cai, Baoxin Zhang, Dongzhu Duan, Jincai Wu, Jianguo Fang · 2012 · Toxicology and Applied Pharmacology
  55. Dithiolethiones for cancer chemoprevention: where do we stand?
    Yuesheng Zhang, Rex Munday · 2008 · Molecular Cancer Therapeutics
  56. Über selenhaltige aromatische Verbindungen (VI)
    Rudolf Lesser, R. Weiß · 1924 · Berichte der deutschen chemischen Gesellschaft (A and B Series)
  57. Inulasesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity
    Guowei Wang, Jiang‐Jiang Qin, Xiang‐Rong Cheng, Yun‐Heng Shen, Lei Shan, Hui‐Zi Jin, Weidong Zhang · 2014 · Expert Opinion on Investigational Drugs
  58. Curcumin suppresses constitutive activation of nuclear factor-κB and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines
    Azhar R Hussain, Maqbool Ahmed, Naif A. Al-Jomah, Asma S. Khan, Pulicat Subramanian Manogaran, Mehar Sultana, Jehad Ahmed Abubaker, Leonidas C. Platanias, Khawla Sami Al-Kuraya, Shahab Uddin M.S. · 2008 · Molecular Cancer Therapeutics
  59. TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
    Michael McLoughlin, David J. Orlicky, Justin R. Prigge, Pushya Krishna, Emily A. Talago, Ian Cavigli, Sofi E. Eriksson, Colin G. Miller, Jean A. Kundert, Volkan I. Sayin et al. · 2019 · Proceedings of the National Academy of Sciences
  60. The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity
    Fabiola Paciello, Anna Rita Fetoni, Daniele Mezzogori, Rolando Rolesi, Antonella Di Pino, Gaetano Paludetti, Claudio Grassi, Diana Troiani · 2020 · Scientific Reports
  61. An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors
    Yihebali Chi, Xiaokai Zhan, Hao YU, Guangru Xie, Zhenzhong Wang, Wei Xiao, Yonggang Wang, Fuxing Xiong, Junfeng Hu, Lin Cheng Yang et al. · 2013 · Chinese Medical Journal
  62. Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress
    Sara Rodríguez‐Enríquez, Silvia Cecilia Pacheco-Velázquez, Álvaro Marín‐Hernández, Juan Carlos Gallardo‐Pérez, Diana Xochiquetzal Robledo‐Cadena, Ileana Hernández‐Reséndiz, Jorge D. García-García, Javier Belmont-Díaz, Rebeca López‐Marure, Luz Hernández‐Esquivel et al. · 2019 · Toxicology and Applied Pharmacology
  63. Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma
    Brian W. Morrison, Nicole Adell Doudican, Kirtesh R. Patel, Seth J. Orlow · 2010 · Melanoma Research
  64. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia
    Mark A. Gregory, Angelo D’Alessandro, Francesca Alvarez Calderon, Jihye Kim, Travis G. Nemkov, Biniam Adane, Andrii I. Rozhok, Amit Kumar, Vijay Kumar, Daniel Aaron Pollyea et al. · 2016 · Proceedings of the National Academy of Sciences
  65. Role of Reactive Oxygen Intermediates in Cellular Responses to Dietary Cancer Chemopreventive Agents
    Jędrzej Antosiewicz, Wiesław Ziółkowski, Siddhartha Kar, Anna A. Powolny, Shivendra Vikram Singh · 2008 · Planta Medica
  66. Novel Concepts in the Development of Platinum Antitumor Drugs
    Miguel Angel Fuertes, Josefina Castilla, C. Alonso, J. Perez · 2002 · Anti-Cancer Agents in Medicinal Chemistry
  67. Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells
    Junmin Zhang, Ya Li, Dongzhu Duan, Juan Yao, Kun Gao, Jianguo Fang · 2015 · Biochemical Pharmacology
  68. Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells
    Hung‐Sheng Shang, Hsu‐Feng Lu, Ching‐Hsiao Lee, Han‐Sun Chiang, Yung‐Lin Chu, Ann Chen, Yuh‐Feng Lin, Jing‐Gung Chung · 2018 · Environmental Toxicology
  69. Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase–dependent apoptosis in chronic myelogenous leukemic cells
    Gautam Kumar Bandyopadhyay, Tanusree Biswas, Keshab C. Roy, Swapan Mandal, Chhabinath Mandal, Bikas Chandra Pal, Samir Bhattacharya, Srabanti Rakshit, Dilip Kumar Bhattacharya, Utpal Chaudhuri et al. · 2004 · Blood
  70. Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting mitochondria
    Ahmad Salimi, Mehryar Habibi Roudkenar, Leila Sadeghi, Alireza Mohseni, Enayatollah Seydi, Nahal Pirahmadi, Jalal Pourahmad · 2015 · Redox Biology
  71. The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide‐induced oxidative stress and DNA damages in IMR‐90 cells
    Ching‐Hsein Chen, Tsan‐Zon Liu, Chin‐Hui Chen, Chung Hang Wong, Chi‐Hung Chen, Fung‐Jou Lu, Ssu‐Ching Chen · 2007 · Molecular Nutrition & Food Research
  72. Gallic Acid and Gallates in Human Health and Disease: Do Mitochondria Hold the Key to Success?
    Rekha Yamini Kosuru, Amrita Roy, Sujoy K. Das, Soumen Bera · 2017 · Molecular Nutrition & Food Research
  73. Biological activity of synthetic ionophores: ion transporters as prospective drugs?
    Ignacio Alfonso, Roberto Quesada · 2013 · Chemical Science
  74. Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor–Like Protein
    Tao Zhen, Chuanfeng Wu, Ping Liu, Haiyan Wu, Guang‐Biao Zhou, Ying Lu, Jianxiang Liu, Yang Liang, Keqin Kathy Li, Yueying Wang et al. · 2012 · Science Translational Medicine
  75. Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution
    Delphine Denoyer, Helen B. Pearson, Sharnel A. S. Clatworthy, Zoe M. Smith, Paul S. Francis, Roxana M. Llanos, Irene Volitakis, Wayne Allen Phillips, Peter M. Meggyesy, Shashank Masaldan et al. · 2016 · Oncotarget
  76. A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy
    Spencer Bruce Gibson · 2010 · Autophagy
  77. Thioredoxin Reductase-1 Mediates Curcumin-Induced Radiosensitization of Squamous Carcinoma Cells
    Prashanthi Javvadi, Lauren Michelle Hertan, Rachelle E. Kosoff, Tatini Datta, Johann Kolev, Rosemarie Mick, Stephen W. Tuttle, Constantinos Koumenis · 2010 · Cancer Research
  78. NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance
    Townsend, Danyelle M., He, Lin, Hutchens, Steven, Garrett, Tracy E., Pazoles, Christopher J., Tew, Kenneth D. · 2008 · Cancer Research
  79. Involvement of NADPH Oxidase-mediated Generation of Reactive Oxygen Species in the Apototic Cell Death by Capsaicin in HepG2 Human Hepatoma Cells
    Yong Soo Lee, Young Shin Kang, Ji‐Seon Lee, Sevdalina Nicolova, Jung‐Ae Kim · 2004 · Free Radical Research
  80. Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis
    Daniela Carlisi, Giuseppina Buttitta, Riccardo Di Fiore, Christian A. Scerri, Rosa Drago‐Ferrante, Renza Vento, Giovanni Tesoriere · 2016 · Cell Death and Disease
  81. Reactive oxygen species and immune regulation
    Yang Zhou, Zhijun Min, Bo Yu · 2020 · International Reviews of Immunology
  82. Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid
    Youn-Joo Jung, Young‐Joon Surh · 2001 · Free Radical Biology and Medicine
  83. Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors
    Keshav Karki, Erik Hedrick, Ravi Kasiappan, Un-Ho Jin, Stephen H Safe · 2017 · Cancer Prevention Research
  84. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells
    P Cheng, Zhenhong Ni, Xufang Dai, Bin Wang, Weizhe Ding, Amber Rae Smith, Liang Xu, Dapeng Wu, Fengtian He, Jiqin Lian · 2013 · Cell Death and Disease
  85. Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety
    Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz, Marta Rejmund, Jarosław Polański, Robert Musioł · 2019 · European Journal of Medicinal Chemistry
  86. Small molecule fluorescent probes of protein vicinal dithiols
    Guodong Hu, Huiyi Jia, Lanning Zhao, Dong‐Hyung Cho, Jianguo Fang · 2019 · Chinese Chemical Letters
  87. Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells.
    Larry H Russell, ELIZABETH A. MAZZIO, Ramesh Babu Badisa, Zhi-Ping Zhu, Maryam Agharahimi, Ebenezer T. Oriaku, Carl B. Goodman · 2012 · PubMed
  88. Apoptosis Signal-Regulating Kinase 1–Thioredoxin Complex Dissociation by Capsaicin Causes Pancreatic Tumor Growth Suppression by Inducing Apoptosis
    Kartick Chandra Pramanik, Sanjay Srivastava · 2012 · Antioxidants and Redox Signaling
  89. TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy
    Jiaming Xie, Bin Li, Hong-Pei Yu, Quan-Geng Gao, Wei Li, Haorong Wu, Zheng‐Hong Qin · 2014 · Cancer Research
  90. Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
    Maryam Moussavi · 2005 · Carcinogenesis
  91. Selective Activation of a Prodrug by Thioredoxin Reductase Providing a Strategy to Target Cancer Cells
    Xinming Li, Yanan Hou, Xianke Meng, Chunpo Ge, Huilong Ma, Jin Li, Jianguo Fang · 2018 · Angewandte Chemie International Edition
  92. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
    Tao Shen, Tao Jiang, Min Long, Jun Chen, Dong-Mei Ren, Pak Kin Wong, Eli Chapman, Bo Zhou, Donna D. Zhang · 2015 · Antioxidants and Redox Signaling
  93. NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR
    Shangce Du, Ji Miao, Zhouting Zhu, En Xu, Linsen Shi, Shichao Ai, Feng Wang, Xing Kang, Hong Chen, Xiaofeng Lu et al. · 2018 · Cell Death and Disease
  94. Piperlongumine induces G2/M phase arrest and apoptosis in cholangiocarcinoma cells through the ROS-JNK-ERK signaling pathway
    Sunisa Thongsom, Wipa Suginta, Kyung Jin Lee, Han Choe, Chutima Talabnin · 2017 · APOPTOSIS
  95. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
    Hui Wang, Heng Jiang, Cyril Corbet, Sven de Mey, Lun Law Ka, Thierry Gevaert, Olivier Féron, Mark De Ridder · 2019 · Cancer Letters
  96. Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop
    Yang Wang, Jing Zhang, Zhi‐Hao Huang, Xiaohui Huang, Wei-Bin Zheng, Xingfeng Yin, Yao-Lan Li, Bin Li, Qing‐Yu He · 2017 · Cell Death and Disease
  97. Review of the Syntheses and Activities of Some Sulfur-Containing Drugs
    Criscieli Taynara Barce Ferro, Beatriz Fuzinato dos Santos, Caren D. G. Silva, George Brand, Caren D. G. da Silva, Nelson Luis C. Domingues · 2020 · Current Organic Synthesis
  98. Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway
    Chen · 2009 · Oncology Reports
  99. On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells
    Iris Gehrke, Eric D.J. Bouchard, Sara Beiggi, Armando G. Poeppl, James B. Johnston, Spencer Bruce Gibson, Versha Banerji · 2014 · Clinical Cancer Research
  100. Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer
    Patrick C. O’Leary, Marta Terrile, Małgorzata Bajor, Paweł Gaj, Bryan T. Hennessy, Gordon Brent Mills, Agnieszka Zagożdżon, Darran P. O’Connor, Donal J. Brennan, Kate Connor et al. · 2014 · Breast Cancer Research
  101. Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress
    Qian Sun, Wentao Gao, Patricia Loughran, Rick Shapiro, Jie Fan, Timothy R. Billiar, Melanie J. Scott · 2013 · Journal of Biological Chemistry
  102. Superoxide Production and Reactive Oxygen Species Signaling by Endothelial Nitric-oxide Synthase
    Weihan Wang, Shuibang Wang, Yan Liang, Patricia Madara, Ana Del Pilar Cintron, ROBERT A. WESLEY, Robert L. Danner · 2000 · Journal of Biological Chemistry
  103. Selected Attributes of Polyphenols in Targeting Oxidative Stress in Cancer
    Višnja Stepanić, Ana Čipak Gašparović, Koraljka Gall‐Tros̆elj, Dragan Amić, Neven Žarković · 2015 · Current Topics in Medicinal Chemistry
  104. New Insights for the Use of Quercetin Analogs in Cancer Treatment
    Domenico Iacopetta, Fedora Grande, Anna Caruso, Roberta Alessandra Mordocco, Maria Rosaria Plutino, Luca Scrivano, Jessica Ceramella, Noemi Muià, Carmela Saturnino, Francesco Puoci et al. · 2017 · Future Medicinal Chemistry
  105. HPV-based cervical cancer screening in a population at high risk for HIV infection
    Sharita D. Womack, Zvavahera Mike Chirenje, Lynne Gaffikin, Paul D. Blumenthal, John A. McGrath, Thomas Chipato, Stephen Ngwalle, Marshall Wesley Munjoma, Keerti V. Shah · 2000 · International Journal of Cancer
  106. Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
    Min Ji Seo, Dong Min Lee, In Young Kim, Dongjoo Lee, Min‐Koo Choi, Joo‐Youn Lee, Seok Soon Park, Seong‐Yun Jeong, Eun Kyung Choi, Kyeong Sook Choi · 2019 · Cell Death and Disease
  107. ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress
    Sung‐Yong Yang, Min Cheol Pyo, Mi‐Hyun Nam, Kwang‐Won Lee · 2019 · BMC Complementary and Alternative Medicine
  108. Darinaparsin: a novel organic arsenical with promising anticancer activity
    Koren Kathleen Mann, Barbara Wallner, Izidore S. Lossos, Wilson H. Miller · 2009 · Expert Opinion on Investigational Drugs
  109. Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications
    Nathaniel Edward Bennett Saidu, Gaëlle Noé, Olivier Cerles, Luc Cabel, Niloufar Kavian, Sandrine Chouzenoux, Mathilde Bahuaud, Christiane Chéreau, Carole Nicco, Karen Leroy et al. · 2017 · Molecular Cancer Therapeutics
  110. Studies on Analogues of L-Cysteine and L-Cystine
    Austin S. Weisberger, Leif G. Suhrland · 1956 · Blood
  111. Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis
    Haixia Xu, Changlin Li, Olivier Mozziconacci, Runzhi Zhu, Ying Xu, Yuzhe Tang, Ruibao Chen, Yan Lin Huang, Jeffrey M. Holzbeierlein, Christian Schöneich et al. · 2019 · Free Radical Biology and Medicine
  112. Inhibiting the Activity of NADPH Oxidase in Cancer
    Mariam M. Konaté, Smitha Antony, James H. Doroshow · 2020 · Antioxidants and Redox Signaling
  113. Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells
    Anshul Gupte, Russell J. Mumper · 2007 · Free Radical Biology and Medicine
  114. Thermo–Chemotherapy and Electromotive Drug Administration of Mitomycin C in Superficial Bladder Cancer Eradication
    Renzo Colombo, Renzo Colombo, Maurizio A. Brausi, Maurizio A. Brausi, L. Da Pozzo, L. Da Pozzo, Andrea Salonia, Andrea Salonia, Francesco Montorsi, Francesco Montorsi et al. · 2001 · European Urology
  115. Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress
    Tianyu Liu, Junmin Zhang, Xiao Han, Jianqiang Xu, Yueting Wu, Jianguo Fang · 2019 · Free Radical Biology and Medicine
  116. New Cytotoxic Flavonoids fromThelypteris torresiana
    An‐Shen Lin, Fang‐Rong Chang, Chin‐Chung Wu, Chih‐Chuang Liaw, Yang‐Chang Wu · 2005 · Planta Medica
  117. The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models
    Didier Colin, Emeric Limagne, Kévin Ragot, Gérard Lizard, François Ghiringhelli, Éric Solary, Bruno Chauffert, Norbert Latruffe, Dominique Delmas · 2014 · Cell Death and Disease
  118. Disruption of the redox balance with either oxidative or anti‐oxidative overloading as a promising target for cancer therapy
    Bagher Farhood, Masoud Najafi, Eniseh Salehi, Nasser Hashemi Goradel, Maryam Shabani Nashtaei, Neda Khanlarkhani, Keywan Mortezaee · 2018 · Journal of Cellular Biochemistry
  119. D-penicillamine and other low molecular weight thiols: Review of anticancer effects and related mechanisms
    Saurabh Wadhwa, Russell J. Mumper · 2013 · Cancer Letters
  120. Parthenolide prevents resistance of MDA-MB231 cells to doxorubicin and mitoxantrone: the role of Nrf2
    Daniela Carlisi, Anna DE BLASIO, Rosa Drago‐Ferrante, Riccardo Di Fiore, Giuseppina Buttitta, Marco Morreale, Christian A. Scerri, Renza Vento, Giovanni Tesoriere · 2017 · Cell Death Discovery
  121. NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells
    Ashok Kumar Jayavelu, Jörg P. Müller, Reinhard Bauer, S-A Böhmer, J Lässig, Sabine Cerny‐Reiterer, Wolfgang R. Sperr, Peter Valent, Barbara Maurer, Richard Moriggl et al. · 2015 · Leukemia
  122. Inhibition of Epigallocatechin Gallate on Orthotopic Colon Cancer by Upregulating the Nrf2-UGT1A Signal Pathway in Nude Mice
    Jun-Hua Yuan, Yanqing Li, Xiaoyun Yang · 2007 · Pharmacology
  123. Glucose modulation induces reactive oxygen species and increases P ‐glycoprotein‐mediated multidrug resistance to chemotherapeutics
    Nicole A. Seebacher, Des Raymond Richardson, Patric J. Jansson · 2015 · British Journal of Pharmacology
  124. Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress
    Julien Verrax, Raphaël Beck, Nicolas Dejeans, Christophe Glorieux, Brice Sid, Rozangela Curi Pedrosa, Julio Federico Benites, David Vásquez, Jaime Adolfo Valderrama, Pedro Buc Calderón · 2011 · Anti-Cancer Agents in Medicinal Chemistry
  125. Inhibition of tumor progression by oral piceatannol in mouse 4T1 mammary cancer is associated with decreased angiogenesis and macrophage infiltration
    Hyerim Song, Jae In Jung, Han‐Jin Cho, Song Her, Seung‐Hae Kwon, Rina Yu, Young‐Hee Kang, Ki Won Lee, Jung Han Yoon Park · 2015 · The Journal of Nutritional Biochemistry
  126. Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis
    Xinming Li, Yanan Hou, Jintao Zhao, Jin Li, Song Wang, Jianguo Fang · 2020 · Chemical Science
  127. Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer
    Sander W. Tas, Margriet J. Vervoordeldonk, Paul Peter Tak · 2009 · Current Gene Therapy
  128. Lico A Causes ER Stress and Apoptosis via Up-Regulating miR-144-3p in Human Lung Cancer Cell Line H292
    Gang Chen, Yueping Ma, Zhe Jiang, Yuan Feng, Yueqing Han, Ye-Tian Tang, Juan Zhang, Hui Ni, Xuezheng Li, Ning Li · 2018 · Frontiers in Pharmacology
  129. The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects
    Xiaoyan Sun, Wei‐Guang Wang, Jiao Chen, Xueting Cai, Jie Yang, Yang Yang, Huaijiang Yan, Xiaolan Cheng, Juan Ye, Wuguang Lu et al. · 2016 · Cancer Research
  130. Nrf2‐mediated induction of detoxifying enzymes by alantolactone present in Inula helenium
    Ji Yeon Seo, Soon Sung Lim, Ju Ryoung Kim, Ji‐Sun Lim, Young Ran Ha, In Ae Lee, Eun Ji Kim, Jung Han Yoon Park, Jong‐Sang Kim · 2008 · Phytotherapy Research
  131. ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells
    Di Zhang, Qian Zhou, Dandan Huang, Lu He, Heng Zhang, Bang Hu, Hui Peng, Donglin Ren · 2019 · Biochemical and Biophysical Research Communications
  132. Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: Structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation
    Hyun‐Jeong Kim, Wooseong Kim, Soohwan Yum, Sungchae Hong, Jeong‐Eun Oh, Ji-Woo Lee, Mi‐Kyoung Kwak, Eun Ji Park, Dong Hee Na, Yunjin Jung · 2013 · Free Radical Biology and Medicine
  133. Status of Bi- and Multi-Nuclear Platinum Anticancer Drug Development
    Jinchao Zhang, Liwei Wang, Zhi-Yong Xing, Dandan Liu, Jing Sun, Xiaoliu Li, Ying Zhang · 2010 · Anti-Cancer Agents in Medicinal Chemistry
  134. Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase
    Junmin Zhang, Juan Yao, Shoujiao Peng, Xinming Li, Jianguo Fang · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  135. Phase I Trial of Imexon in Patients With Advanced Malignancy
    Tomislav Dragovich, Michael S. Gordon, David S. Mendelson, Lucas Wong, Manuel Modiano, H.‐H. Sherry Chow, Betty K. Samulitis, Steven J O'Day, Kathryn Grenier, Evan M. Hersh et al. · 2007 · Journal of Clinical Oncology
  136. Potent protection of gallic acid against DNA oxidation: Results of human and animal experiments
    Franziska Ferk, Asima Chakraborty, Walter Rudolf Jäger, Michael Kundi, Julia Bichler, Miroslav Mišík, Karl‐Heinz Wagner, Bettina Grasl‐Kraupp, Sandra Sagmeister, Gerald Haidinger et al. · 2011 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
  137. Sulindac Enhances the Killing of Cancer Cells Exposed to Oxidative Stress
    Maria A. Marchetti, Lionel Resnick, Edna Gamliel, Shailaja Kesaraju, Herbert Weissbach, David Binninger · 2009 · PLoS ONE
  138. Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling
    D. Lynn Kirkpatrick, Garth Powis · 2016 · Antioxidants and Redox Signaling
  139. Genistein Prevents Development of Spontaneous Ovarian Cancer and Inhibits Tumor Growth in Hen Model
    Kazım Şahin, Engin Yenice, Birdal Bilir, Cemal Orhan, Mehmet Tuzcu, Nurhan Şahin, İbrahim H. Özercan, Nashwa N. Kabil, Bülent Özpolat, Ömer Küçük · 2019 · Cancer Prevention Research
  140. The hypoxic tumour microenvironment: A safe haven for immunosuppressive cells and a therapeutic barrier to overcome
    Wai Hoong Chang, Alvina Grace Lai · 2020 · Cancer Letters
  141. Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival
    Chien-chung Chen, Hui‐Ling Chen, Chia‐Wen Hsieh, Yiling Yang, Being‐Sun Wung · 2010 · Acta Pharmacologica Sinica
  142. The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite
    Schildknecht, S., Weber, A., Gerding, H., Pape, R., Robotta, M., Drescher, M., Marquardt, A., Daiber, A., Ferger, B., Leist, M. · 2013 · Current Medicinal Chemistry
  143. Causality and Chance in the Development of Cancer
    Lucio Luzzatto, Pier Paolo Pandolfi · 2015 · New England Journal of Medicine
  144. Selective Anticancer Activity of Acacetin Against Chronic Lymphocytic Leukemia Using Both In Vivo and In Vitro Methods: Key Role of Oxidative Stress and Cancerous Mitochondria
    Ahmad Salimi, Mehryar Habibi Roudkenar, Leila Sadeghi, Alireza Mohseni, Enayatollah Seydi, Nahal Pirahmadi, Jalal Pourahmad · 2016 · Nutrition and Cancer
  145. Redox-Dependent Copper Carrier Promotes Cellular Copper Uptake and Oxidative Stress-Mediated Apoptosis of Cancer Cells
    Junmin Zhang, Dongzhu Duan, Jianqiang Xu, Jianguo Fang · 2018 · ACS Applied Materials & Interfaces
  146. Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases
    Timothy E. Bael, Bercedis L. Peterson, Jared Gollob · 2008 · Melanoma Research
  147. Activation of oncogenes and/or inactivation of anti-oncogenes by reactive oxygen species
    H Wei · 1992 · Medical Hypotheses
  148. Endoplasmic Reticulum Stress Signaling Is Involved in Mitomycin C(MMC)-Induced Apoptosis in Human Fibroblasts via PERK Pathway
    Kun Shi, Daode Wang, Xiaojian Cao, Yingbin Ge · 2013 · PLoS ONE
  149. An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation
    Anshul Gupte, Russell J. Mumper · 2006 · Journal of Inorganic Biochemistry
  150. Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells
    Takashi Hosono, Tomomi Hosono-Fukao, Kahoru Inada, Rie Tanaka, Haruhisa Yamada, Yuji Iitsuka, T. Seki, Isao Hasegawa, T. Ariga · 2008 · Carcinogenesis
  151. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T
    Alzbeta Kamenickova, Eva Anzenbacherová, Petr Pávek, Anatoly A. Soshilov, Michael S. Denison, Pavel Anzenbacher, Zdeněk Dvořák · 2013 · Toxicology Letters
  152. Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system
    Hee Shim Choi, Joong Sup Shim, Ju-A Kim, Sang Won Kang, Ho Jeong Kwon · 2007 · Biochemical and Biophysical Research Communications
  153. Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity
    Jiayu Zhang, Xue Mei Zhou, Wenbo Wu, Jiachun Wang, Hong Xie, Zhigang Wu · 2017 · Environmental Toxicology and Pharmacology
  154. Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
    Hon Liong Soo, Shun Ying Quah, Ibrahim Sulaiman, Sreenivasa Rao Sagineedu, Jonathan Chee Woei Lim, Johnson Stanslas · 2019 · Drug Discovery Today
  155. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells
    Patricia Sancho, Isabel Fabregat · 2011 · Biochemical Pharmacology
  156. Differences in intracellular sites of action of Adriamycin in neoplastic and normal differentiated cells
    Ken-ichi Kiyomiya, Saburo Matsuo, Masaru Kurebe · 2000 · Cancer Chemotherapy and Pharmacology
  157. Current Development of ROS-Modulating Agents as Novel Antitumor Therapy
    Nan Wang, Yue Wu, Jinlei Bian, Qian Xue, Hongzhi Lin, Haopeng Sun, Qidong You, Xiaojin Zhang · 2017 · Current Cancer Drug Targets
  158. A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines
    Zuanel Diaz, Koren Kathleen Mann, Sophie Marcoux, Maria Kourelis, Myrian Colombo, Philip B. Komarnitsky, Wilson H. Miller · 2008 · Leukemia
  159. Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- ando-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog
    Lin Dong, Fang Dai, Landi Sun, Bo Zhou · 2015 · Molecular Nutrition & Food Research
  160. Overexpression of Protein Kinase Cζ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation
    Christine Bezombes, Aurélie de Thonel, Andriana Apostolou, Thierry Louat, Jean‐Pierre Jaffrézou, Guy Laurent, Anne Quillet‐Mary · 2002 · Molecular Pharmacology
  161. ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
    Peng Wang, Sun-Dong Zhang, Jiao Jiao, Wéi Wang, Liang Yu, Xuelian Zhao, Litao Wang, Dong Meng, Yujie Fu · 2019 · Toxicology and Applied Pharmacology
  162. Long Term Effect of Curcumin in Regulation of Glycolytic Pathway and Angiogenesis via Modulation of Stress Activated Genes in Prevention of Cancer
    Laxmidhar Das, Manjula Vinayak · 2014 · PLoS ONE
  163. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells
    J-K Hou, Y Huang, Weiyang He, Z-W Yan, Lifei Fan, M-H Liu, W-L Xiao, HD Sun, G-Q Chen · 2014 · Cell Death and Disease
  164. Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death
    V. Vendrely, Samuel Amintas, Cécile Noel, Isabelle Moranvillier, Isabelle Lamrissi‐Garcia, Benoı̂t Rousseau, Soulé Coulibaly, Aurélie Bedel, François Moreau‐Gaudry, Étienne Buscail et al. · 2019 · Cancer Letters
  165. Cinnamic acids as new inhibitors of 17β-hydroxysteroid dehydrogenase type 5 (AKR1C3)
    Petra Brožič, Barbara Golob, Nataša Gomboc, Tea Lanišnik Rižner, Stanislav Gobec · 2005 · Molecular and Cellular Endocrinology
  166. The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells
    Sukriti Krishan, Des Raymond Richardson, Sumit Sahni · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  167. Xanthatin Promotes Apoptosis via Inhibiting Thioredoxin Reductase and Eliciting Oxidative Stress
    Ruijuan Liu, Danfeng Shi, Junmin Zhang, Xinming Li, Xiao Han, Xiaojun Yao, Jianguo Fang · 2018 · Molecular Pharmaceutics
  168. Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts
    James H. Doroshow, Shikha Gaur, Susan Markel, Jiamo Lu, Josephus N.A. van Balgooy, Timothy Walter Synold, Bixin Xi, Xiwei Wu, Agnes N. Juhasz · 2013 · Free Radical Biology and Medicine
  169. Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo
    Qiang Tan, Jing Li, Hanwei Yin, Lihui Wang, Wan-chen Tang, Fang Zhao, Xinmin Liu, Huihui Zeng · 2009 · Investigational New Drugs
  170. Epirubicin-Induced Oxidative DNA Damage and Evidence for Its Repair in Lymphocytes of Cancer Patients Who Are Undergoing Chemotherapy
    Ryszard Oliński, Paweł Jaruga, Marek Foksiński, Karol Białkowski, Jerzy Tujakowski · 1997 · Molecular Pharmacology
  171. Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging
    Laura Fási, Florent Di Meo, Ching‐Ying Kuo, Sonja Stojković Burić, Ana Martins, Norbert Kúsz, Zoltán Béni, Miklós Dékány, György Tibor Balogh, Milica Pešić et al. · 2019 · Journal of Medicinal Chemistry
  172. Apocynin, an NADPH oxidase inhibitor, suppresses progression of prostate cancer via Rac1 dephosphorylation
    Shugo Suzuki, Pornsiri Pitchakarn, Shinya Sato, Tomoyuki Shirai, Satoru Takahashi · 2013 · Experimental and Toxicologic Pathology
  173. Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice
    Jayson X. Chen, Guangxun Li, Hong Wang, Anna Liu, Mao‐Jung Lee, Kenneth R. Reuhl, Nanjoo Suh, Maarten C. Bosland, Chung Shu Yang · 2015 · Cancer Letters
  174. Free radical modes of cytotoxicity of adriamycin® and streptonigrin
    William DeGraff, Stephen M. Hahn, James B. Mitchell, Murali C. Krishna · 1994 · Biochemical Pharmacology
  175. Prophylactic role of vitamin K supplementation on vascular inflammation in type 2 diabetes by regulating the NF-κB/Nrf2 pathway via activating Gla proteins
    Anjum Dihingia, Dibyajyoti Ozah, Pranab Kumar Baruah, Jatin Kalita, Prasenjit Manna · 2017 · Food & Function
  176. Mkp-1 is required for chemopreventive activity of butylated hydroxyanisole and resveratrol against colitis-associated colon tumorigenesis
    Zhao-Hong Zheng, Yeru Chen, Jianan Huang, Hong Deng, Xiuwen Tang, Xiu Jun Wang · 2019 · Food and Chemical Toxicology
  177. Toxicity against gastric cancer cells by combined treatment with 5-fluorouracil and mitomycin c: implication in oxidative stress
    Toshiyuki Matsunaga, Yoshitaka Tsuji, Kairyu Kaai, Saki Kohno, Renzo Hirayama, David Alpers, Tsugikazu Komoda, Akira Hara · 2009 · Cancer Chemotherapy and Pharmacology
  178. The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: Possible involvement of nuclear factor-κB-dependent pathway
    Linxiang Lan, Fang Zhao, Yan Wang, Huihui Zeng · 2006 · European Journal of Pharmacology
  179. Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells
    Tsuyoshi Yamamoto, Hirofumi Nakano, Kazuro Shiomi, Kiyofumi Wanibuchi, Hisashi Masui, Takashi Takahashi, Yasuteru Urano, Tohru Kamata · 2017 · Biological and Pharmaceutical Bulletin
  180. Adenanthin targets proteins involved in the regulation of disulphide bonds
    Angelika Muchowicz, Małgorzata Firczuk, Justyna Chlebowska, Dominika Nowis, Joanna Stachura, Joanna Barankiewicz, Anna Trzeciecka, Szymon Kłossowski, Ryszard Ostaszewski, Radosław Zagożdżon et al. · 2014 · Biochemical Pharmacology
  181. Protoflavones: a class of unusual flavonoids as promising novel anticancer agents
    Attila Hunyadi, Ana Martins, Balázs Dankó, Fang‐Rong Chang, Yang‐Chang Wu · 2013 · Phytochemistry Reviews
  182. Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway
    Lan Wang, Min Wang, Jing Hu, Wei Shen, Junjie Hu, Yi Yao, Xifeng Wang, Curimbacus M. Afzal, Rong Ma, Gang Li · 2016 · European Journal of Pharmacology
  183. Targeting thioredoxin reductase by plumbagin contributes to inducing apoptosis of HL-60 cells
    Junmin Zhang, Shoujiao Peng, Xinming Li, Ruijuan Liu, Xiao Han, Jianguo Fang · 2017 · Archives of Biochemistry and Biophysics
  184. Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapy
    Jimmy Stalin, Sarah Garrido‐Urbani, Freddy Heitz, Cédric Szyndralewiez, Stéphane Jemelin, Oriana Coquoz, Curzio Rüegg, Beat A. Imhof · 2019 · Life Science Alliance
  185. Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone
    Xiazhen Bao, Fang Dai, Xinrong Li, Bo Zhou · 2018 · Free Radical Biology and Medicine
  186. Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?
    J Butler, Brigid M. Hoey · 1987 · PubMed
  187. Improvement of green tea polyphenol with milk on skin with respect to antioxidation in healthy adults: a double-blind placebo-controlled randomized crossover clinical trial
    Hui‐Fang Chiu, Tung‐Yi Lin, You‐Cheng Shen, Kamesh Venkatakrishnan, Chin‐Kun Wang · 2015 · Food & Function
  188. Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent
    Junmin Zhang, Yaping Liu, Danfeng Shi, Guodong Hu, Baoxin Zhang, Xinming Li, Ruijuan Liu, Xiao Han, Xiaojun Yao, Jianguo Fang · 2017 · European Journal of Medicinal Chemistry
  189. Berichte der deutschen chemischen Gesellschaft (A and B Series)
    2013 · Berichte der deutschen chemischen Gesellschaft (A and B Series)
  190. A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis
    Jinhua Liu, Chenglong Mu, Wen Yue, Jie Li, Biao Ma, Lixia Zhao, Lei Liu, Quan Chen, Yan Chen, Hai‐Yang Liu et al. · 2013 · Free Radical Biology and Medicine
  191. Antitumor activity, optimum administration method and pharmacokinetics of 13,14-dihydro-15-deoxy-δ7-prostaglandin A1 methyl ester (TEI-9826) integrated in lipid microspheres (Lipo TEI-9826)
    Shoji Fukushima, Yoshikazu Takeuchi, Shuichi Kishimoto, S. Yamashita, K Uetsuki, Satoshi Shirakawa, Masaaki Suzuki, Kyoji Furuta, Ryōji Noyori, Hiroshi Sasaki et al. · 2001 · Anti-Cancer Drugs
  192. Diterpenoids from Isodon adenantha
    Bei Jiang, Hui Yang, Malin Li, Ai‐Jun Hou, Quan‐Bin Han, Sujun Wang, Sheng‐Hong Li, Han‐Dong Sun · 2002 · Journal of Natural Products
  193. Combined treatment with vitamin C and sulindac synergistically induces p53- and ROS-dependent apoptosis in human colon cancer cells
    Eun-Yeung Gong, Yu Jin Shin, Ih-Yeon Hwang, Jeong Hee Kim, Seung-Mi Kim, Jai-Hee Moon, Jae-Sik Shin, Dae‐Hee Lee, Dae Young Hur, Dong-Hoon Jin et al. · 2016 · Toxicology Letters
  194. Cisplatin combination chemotherapy induces oxidative stress in advance non small cell lung cancer patients.
    Anand Srivastava, Abhilasha Gupta, Shruti Srivastava, S. M. Natu, Balraj Mittal, M.P.S. Negi, Rajendra Prasad · 2010 · PubMed
  195. Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions
    Yaping Yang, Kefan Zhang, Yawei Wang, Mengjia Li, Xiaoxue Sun, Zhihong Liang, Liwei Wang, Lixin Chen, Haifeng Yang, Linyan Zhu · 2016 · Scanning
  196. Neferine Enhances the Antitumor Effect of Mitomycin‐C in Hela Cells Through the Activation of p38‐MAPK Pathway
    Wassim Eid, Wafaa M. Abdel-Rehim · 2017 · Journal of Cellular Biochemistry
  197. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by α-lipoic acid in human leukemia HL-60 cells
    Hsieh · 1992 · International Journal of Oncology
  198. Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: implications for dithiolethione chemoprotection
    Zhenquan Jia, Hong Zhu, Michael A. Trush, Hara Prasad Misra, Yunbo Li · 2007 · Molecular and Cellular Biochemistry
  199. Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity
    Zhuoxiao Cao, Seema Hallur, Harry Z Qiu, Xingxiang Peng, Yunbo Li · 2004 · Biochemical and Biophysical Research Communications
  200. Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results
    Robert John Amato, Jaroslaw Jac, Joan Hernandez-McClain · 2008 · Clinical Genitourinary Cancer