The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cyanobacterial toxins – occurrence, biosynthesis and impact on human affairs
Abstract
Mass developments of cyanobacteria (“blue‐green algae”) in lakes and brackish waters have repeatedly led to serious concerns due to their frequent association with toxins. Among these are the widespread hepatotoxins microcystin (MC) and nodularin (NOD). Here, we give an overview about the ecostrategies of the diverse toxin‐producing species and about the genes and enzymes that are involved in the biosynthesis of the cyclic peptides. We further summarize current knowledge about toxicological mechanisms of MC and NOD, including protein phosphatase inhibition, oxidative stress and their tumor‐promoting capabilities. One biotransformation pathway for MC is described. Mechanisms of cyanobacterial neurotoxins (anatoxin‐a, homanatoxin‐a, and anatoxin‐a(s)) are briefly explained. We highlight selected cases of human fatalities related to the toxins. A special focus is given to evident cases of contamination of food supplements with cyanobacterial toxins, and to the necessary precautions.
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Citations
Cites
Anatoxin-a, a toxic alkaloid from Anabaena flos-aquae NRC-44h
Devlin, J. P., Edwards, O. E., Gorham, P. R., Hunter, N. R., Pike, R. K., & Stavric, B. (1977) · Canadian Journal of Chemistry · doi:10.1139/v77-189 · Cited by 378
Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
Blunt, J. W., Copp, B. R., Hu, W.-P., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2008) · Natural Product Reports · doi:10.1039/b701534h · Cited by 365
Cornelis, P., & Matthijs, S. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00369.x · Cited by 278
Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulence
Cendrowski, S., MacArthur, W., & Hanna, P. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03861.x · Cited by 229
Berry, J., Gantar, M., Perez, M., Berry, G., & Noriega, F. (2008) · Marine Drugs · doi:10.3390/md6020117 · Cited by 231
Metadata
- Authors
- Dittmann, E., & Wiegand, C.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 50
- Issue
- 1
- Pages
- 7-17
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2023988904
- Cited by
- 430
- References
- 1
- FWCI
- 14.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dittmann, E., & Wiegand, C. (2006). Cyanobacterial toxins – occurrence, biosynthesis and impact on human affairs. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.200500162
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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