Anatoxin-a, a toxic alkaloid from Anabaena flos-aquae NRC-44h
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A toxic alkaloid, anatoxin-a, has been isolated from mass cultures of a unialgal clone, NRC-44h, of the freshwater blue-green algae Anabaena flos-aquae (Lyngb.) de Bréb., and its structure determined.
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Anatoxin may pose a health risk because it is an acetylcholine receptor agonist causing paralysis, muscle contractions, and respiratory failure.
“The latter toxin may pose a health risk because it is an acetylcholine receptor agonist causing paralysis, muscle contractions, and respiratory failure [36].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [36]
The Abstract reports that the toxin killed mice within minutes, preceded by gasps and tremors. Properties and Structure describes its reported activity as a postsynaptic depolarizing neuromuscular blocking agent. These passages support toxicity and a neuromuscular effect, but do not establish acetylcholine-receptor agonism or explicitly identify paralysis, muscle contractions, and respiratory failure as its effects. (LLM, conf=0.86)
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“The latter toxin may pose a health risk because it is an acetylcholine receptor agonist causing paralysis, muscle contractions, and respiratory failure [36].”
BackgroundMethodFIRST REPORT OF THE CYANOTOXIN ANATOXIN‐A FROM APHANIZOMENON ISSATSCHENKOI (CYANOBACTERIA)1
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Enantioselective synthesis of (+)-anatoxin-a via enyne metathesis
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- Authors
- Devlin, J. P., Edwards, O. E., Gorham, P. R., Hunter, N. R., Pike, R. K., & Stavric, B.
- ORCID
- Devlin, J. P.
- Venue
- Canadian Journal of Chemistry
- Publisher
- Canadian Science Publishing
- Published
- 1977-04-15
- Volume
- 55
- Issue
- 8
- Pages
- 1367-1371
- ISSN
- 0008-4042 (ISSN-L)
- 1480-3291
- OpenAlex
- W2015312835
- Cited by
- 378
- References
- 1
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 18 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 19 · 2015: 12 · 2014: 17 · 2013: 12 · 2012: 14
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Chemistry (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Environmental Science › Environmental Chemistry › Marine Toxins and Detection Methods
- Keywords
- anatoxin-a, toxic alkaloids, Anabaena flos-aquae, cyanobacteria, structure elucidation, natural product isolation, mass culture
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