The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present
Open accessAbstract
Plant sterols and stanols are natural food ingredients found in plants. It was already shown in 1950 that they lower serum low‐density lipoprotein cholesterol (LDL‐C) concentrations. Meta‐analysis has reported that a daily intake of 2.5 g plant sterols/stanols reduced serum LDL‐C concentrations up to 10%. Despite many studies, the underlying mechanism remains to be elucidated. Therefore, the proposed mechanisms that have been presented over the past decades will be described and discussed in the context of the current knowledge. In the early days, it was suggested that plant sterols/stanols compete with intestinal cholesterol for incorporation into mixed micelles as well as into chylomicrons. Next, the focus shifted toward cellular processes. In particular, a role for sterol transporters localized in the membranes of enterocytes was suggested. All these processes ultimately lowered intestinal cholesterol absorption. More recently, the existence of a direct secretion of cholesterol from the circulation into the intestinal lumen was described. First results in animal studies suggested that plant sterols/stanols activate this pathway, which also explains the increased fecal neutral sterol content and as such could explain the cholesterol‐lowering activity of plant sterols/stanols.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cholesterol Treatment Trialists' (CTT) Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)61350-5 · Cited by 6,550
Plant sterol and stanol margarines and health
Law, M. (2000) · BMJ · doi:10.1136/bmj.320.7238.861 · Cited by 729
Abumweis, S., Barake, R., & Jones, P. (2008) · Food & Nutrition Research · doi:10.3402/fnr.v52i0.1811 · Cited by 369
Musa-Veloso, K., Poon, T. H., Elliot, J. A., & Chung, C. (2011) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.02.001 · Cited by 195
Catherine C. Y., C., Chen, J., Thomas, M. A., Cheng, D., Veronica A., D. P., Newton, R. S., Pape, M. E., & Chang, T.-Y. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29532 · Cited by 158
Cited by
National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
Jacobson, T. A., Maki, K. C., Orringer, C. E., Jones, P. H., Kris-Etherton, P., Sikand, G., La Forge, R., Daniels, S. R., Wilson, D. P., Morris, P. B., et al. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.09.002 · Cited by 784
Gylling, H., Plat, J., Turley, S., Ginsberg, H. N., Ellegård, L., Jessup, W., Jones, P. J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.043 · Cited by 529
Self-citationTrautwein, E. A., & McKay, S. (2020) · Nutrients · doi:10.3390/nu12092671 · Cited by 257
Phytochemomics and Other Omics for Permitting Health Claims Made on Foods
del Castillo, M. D., Martinez-Saez, N., Amigo-Benavent, M., & Silvan, J. M. (2013) · Food Research International · doi:10.1016/j.foodres.2013.05.014 · Cited by 26
Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens
Malina, D. M. T., Fonseca, F. A., Barbosa, S. A., Kasmas, S. H., Machado, V. A., França, C. N., Borges, N. C., Moreno, R. A., & Izar, M. C. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.04.003 · Cited by 25
Metadata
- Authors
- Smet, E. D., Mensink, R. P., & Plat, J.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2012-05-24
- Volume
- 56
- Issue
- 7
- Pages
- 1058-1072
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2041498503
- Cited by
- 275
- References
- 5
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present. https://app.cochat.ai/papers/10.1002/mnfr.201100722
- The paper
- Smet, E. D., Mensink, R. P., & Plat, J. (2012). Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.201100722
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
