The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential
Abstract
Diabetes has emerged as a major threat to worldwide health. The exact mechanisms underlying the disease are unknown; however, there is growing evidence that the excess generation of reactive oxygen species (ROS) associated with hyperglycemia, causes oxidative stress in a variety of tissues. In this context, various natural compounds with pleiotropic actions like α‐lipoic acid (LA) are of interest, especially in metabolic diseases such as diabetes. LA, either as a dietary supplement or a therapeutic agent, modulates redox potential because of its ability to match the redox status between different subcellular compartments as well as extracellularly. Both the oxidized (disulfide) and reduced (di‐thiol: dihydro‐lipoic acid, DHLA) forms of LA show antioxidant properties. LA exerts antioxidant effects in biological systems through ROS quenching but also via an action on transition metal chelation. Dietary supplementation with LA has been successfully employed in a variety of in vivo models of disease associated with an imbalance of redox status: diabetes and cardiovascular diseases. The complex and intimate association between increased oxidative stress and increased inflammation in related disorders such as diabetes, makes it difficult to establish the temporal sequence of the relationship.
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1 retracted
Retracted: Alpha-lipoic acid supplementation and diabetes: Nutrition Reviews©, Vol. 66, No. 11
Singh, U., & Jialal, I. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00118.x · Cited by 185
RetractedThe mitochondrial permeability transition
Zoratti, M., & Szabò, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,401
Alpha-lipoic acid as a biological antioxidant
Packer, L., Witt, E. H., & Tritschler, H. J. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00017-r · Cited by 1,979
Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726
The therapeutic potential of carbon monoxide
Motterlini, R., & Otterbein, L. E. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3228 · Cited by 1,638
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
Zhang, D. D., Lo, S.-C., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,254
Fong, D. S., Aiello, L., Gardner, T. W., King, G. L., Blankenship, G., Cavallerano, J. D., Ferris, F. L., Klein, R., & for the American Diabetes Association (2004) · Diabetes Care · doi:10.2337/diacare.27.2007.s84 · Cited by 1,082
Lipid peroxidation: Physiological levels and dual biological effects
Niki, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.032 · Cited by 1,006
Hercberg, S., Galan, P., Preziosi, P., Bertrais, S., Mennen, L., Malvy, D., Roussel, A.-M., Favier, A., & Briançon, S. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.21.2335 · Cited by 956
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Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
Zhang, Y.-H., Wang, D.-W., Xu, S.-F., Zhang, S., Fan, Y.-G., Yang, Y.-Y., Guo, S.-Q., Wang, S., Guo, T., Wang, Z.-Y., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.11.001 · Cited by 304
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Macaron, G., & Ontaneda, D. (2019) · Biomedicines · doi:10.3390/biomedicines7030056 · Cited by 70
Metadata
- Authors
- Rochette, L., Ghibu, S., Richard, C., Zeller, M., Cottin, Y., & Vergely, C.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 57
- Issue
- 1
- Pages
- 114-125
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1996531619
- Cited by
- 297
- References
- 105
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
