Cited by 70Radiomics and Machine Learning in Medical ImagingMRI in cancer diagnosisColorectal Cancer Surgical Treatments

Treatment response prediction using MRI-based pre-, post-, and delta-radiomic features and machine learning algorithms in colorectal cancer

Open access
Shayesteh, Sajad, Nazari, Mostafa, Salahshour, Ali, Sandoughdaran, Saleh, Hajianfar, Ghasem, Khateri, Maziar, Yaghobi Joybari, Ali, Jozian, Fariba +4 more·2021·Medical Physics

Abstract

Objectives: We evaluate the feasibility of treatment response prediction using MRI‐based pre‐, post‐, and delta‐radiomic features for locally advanced rectal cancer (LARC) patients treated by neoadjuvant chemoradiation therapy (nCRT). Materials and Methods: This retrospective study included 53 LARC patients divided into a training set (Center#1, n = 36) and external validation set (Center#2, n = 17). T2‐weighted (T2W) MRI was acquired for all patients, 2 weeks before and 4 weeks after nCRT. Ninety‐six radiomic features, including intensity, morphological and second‐ and high‐order texture features were extracted from segmented 3D volumes from T2W MRI. All features were harmonized using ComBat algorithm. Max‐Relevance‐Min‐Redundancy (MRMR) algorithm was used as feature selector and k‐nearest neighbors (KNN), Naïve Bayes (NB), Random forests (RF), and eXtreme Gradient Boosting (XGB) algorithms were used as classifiers. The evaluation was performed using the area under the receiver operator characteristic (ROC) curve (AUC), sensitivity, specificity and accuracy. Results: In univariate analysis, the highest AUC in pre‐, post‐, and delta‐radiomic features were 0.78, 0.70, and 0.71, for GLCM_IMC1, shape (surface area and volume) and GLSZM_GLNU features, respectively. In multivariate analysis, RF and KNN achieved the highest AUC (0.85 ± 0.04 and 0.81 ± 0.14, respectively) among pre‐ and post‐treatment features. The highest AUC was achieved for the delta‐radiomic‐based RF model (0.96 ± 0.01) followed by NB (0.96 ± 0.04). Overall. Delta‐radiomics model, outperformed both pre‐ and post‐treatment features (P‐value <0.05). Conclusion: Multivariate analysis of delta‐radiomic T2W MRI features using machine learning algorithms could potentially be used for response prediction in LARC patients undergoing nCRT. We also observed that multivariate analysis of delta‐radiomic features using RF classifiers can be used as powerful biomarkers for response prediction in LARC.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/mp.14896

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Birtalan E. Prognostic biomarkers of head neck cancer, PhD Thesis, Semmelweis University, Hungary; 2018.

Cited by

Sorted by citations

Authors
Shayesteh, S., Nazari, M., Salahshour, A., Sandoughdaran, S., Hajianfar, G., Khateri, M., Yaghobi Joybari, A., Jozian, F., Fatehi Feyzabad, S. H., Arabi, H., Shiri, I., & Zaidi, H.
Affiliations
  • Alborz University of Medical Sciences (IR)
  • Shahid Beheshti University (IR)
  • Iran University of Medical Sciences (IR)
  • Islamic Azad University, Tehran (IR)
  • Department of Radiation Oncology Shahid Beheshti University of Medical Sciences Tehran Iran
  • Rajaie Cardiovascular, Medical &amp; Research Centre Iran University of Medical Science Tehran Iran
  • University Hospital of Geneva (CH)
  • University of Geneva (CH)
Corresponding author
Zaidi, Habib
Venue
Medical Physics
Publisher
Wiley
Published
2021-05-17
Volume
48
Issue
7
Pages
3691-3701
ISSN
  • 0094-2405 (ISSN-L)
  • 2473-4209
OpenAlex
W3157805232
Cited by
70
References
60
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 22 · 2021: 18 · 2020: 3
FWCI
7.52
Type
journal article
Language
en
Open access
Locations
  • Medical Physics (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, public-domain)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320030_176052)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords
locally advanced rectal cancer, treatment response prediction, delta radiomics, MRI radiomics, T2-weighted MRI, texture features, GLCM features, combat, mRMR feature selection, random forest, k-nearest neighbors, biomarkers
MeSH terms
Machine Learning, Algorithms, Bayes Theorem, Humans, Magnetic Resonance Imaging, Retrospective Studies, Colorectal Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review