The DOI matches its Crossref record.
Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin
Abstract
Basic chromosomal proteins were extracted from the sperm of fertile and infertile human males. The relative proportions of protamine 1, 2, and 3 were determined by scanning microdensitometry following electrophoresis of total protamine in polyacrilamide gels. The findings were as follows: (1) The proportion of protamine P(2 + 3) in sperm obtained from infertile males was lower than that in fertile males. (2) Protamine P(2 + 3) in infertile human males showed reduced affinity to DNA. The possibility that some cases of human male infertility may be due to mutation within the protamine P2 gene is discussed. © 1993 Wiley‐Liss, Inc.
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Citations
Cited by
Protamines and male infertility
Oliva, R. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml009 · Cited by 802
The protamine family of sperm nuclear proteins
Balhorn, R. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-227 · Cited by 773
Nature of DNA Damage in Ejaculated Human Spermatozoa and the Possible Involvement of Apoptosis1
Sakkas, D., Moffatt, O., Manicardi, G. C., Mariethoz, E., Tarozzi, N., & Bizzaro, D. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.4.1061 · Cited by 447
Miller, D., Brinkworth, M., & Iles, D. (2010) · Reproduction · doi:10.1530/rep-09-0281 · Cited by 416
Seli, E., Gardner, D. K., Schoolcraft, W. B., Moffatt, O., & Sakkas, D. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.12.039 · Cited by 411
Metadata
- Authors
- Belokopytova, I. A., Kostyleva, E. I., Tomilin, A. N., & Vorob'ev, V. I.
- Venue
- Molecular Reproduction and Development
- Publisher
- Wiley
- Published
- 1993-01
- Volume
- 34
- Issue
- 1
- Pages
- 53-57
- ISSN
- 1040-452X (ISSN-L)
- 1098-2795
- OpenAlex
- W2088727561
- Cited by
- 176
- References
- 0
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin. https://app.cochat.ai/papers/10.1002/mrd.1080340109
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- Belokopytova, I. A., Kostyleva, E. I., Tomilin, A. N., & Vorob'ev, V. I. (1993). Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin. Molecular Reproduction and Development. https://doi.org/10.1002/mrd.1080340109
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