The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Gd‐DTPA2− as a measure of cartilage degradation
Abstract
Glycosaminoglycans (GAGs) are the main source of tissue fixed charge density (FCD) in cartilage, and are lost early in arthritic diseases. We tested the hypothesis that, like Na+, the charged contrast agent Gd‐DTPA 2‐ (and hence proton T1) could be used to measure tissue FCD and hence GAG concentration. NMR spectroscopy studies of cartilage explants demonstrated that there was a strong correlation (r > 0.96) between proton T1 in the presence of Gd‐DTPA 2‐ and tissue sodium and GAG concentrations. An ideal one‐compartment electrochemical (Donnan) equilibrium model was examined as a means of quantifying FCD from Gd‐DTPA 2‐ concentration, yielding a value 50% less but linearly correlated with the validated method of quantifying FCD from Na+. These data could be used as the basis of an empirical model with which to quantify FCD from Gd‐DTPA 2‐ concentration, or a more sophisticated physical model could be developed. Spatial distributions of FCD were easily observed in T1‐weighted MRI studies of trypsin and interleukin‐1 induced cartilage degradation, with good histological correlation. Therefore, equilibration of the tissue in Gd‐DTPA 2‐ gives us the opportunity to directly image (through T1, weighting) the concentration of GAG, a major and critically important macromolecule in cartilage. Pilot clinical studies demonstrated Gd‐DTPA 2‐ penetration into cartilage, suggesting that this technique is clinically feasible.
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Self-citationQuantification of T1 values by SNAPSHOT-FLASH NMR imaging
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Studies of Gd‐DTPA relaxivity and proton exchange rates in tissue
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Magnetization transfer in cartilage and its constituent macromolecules
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Self-citationHigh‐speed multislice T1 mapping using inversion‐recovery echo‐planar imaging
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Cited by
The Basic Science of Articular Cartilage: Structure, Composition, and Function
Sophia Fox, A. J., Bedi, A., & Rodeo, S. A. (2009) · Sports Health: A Multidisciplinary Approach · doi:10.1177/1941738109350438 · Cited by 2,774
In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
Li, X., Benjamin Ma, C., Link, T. M., Castillo, D.-D., Blumenkrantz, G., Lozano, J., Carballido-Gamio, J., Ries, M., & Majumdar, S. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.01.011 · Cited by 485
23Na MRI accurately measures fixed charge density in articular cartilage
Shapiro, E. M., Borthakur, A., Gougoutas, A., & Reddy, R. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10054 · Cited by 261
Advances in Imaging of Osteoarthritis and Cartilage
Roemer, F. W., Crema, M. D., Trattnig, S., & Guermazi, A. (2011) · Radiology · doi:10.1148/radiol.11101359 · Cited by 220
Wang, N., Badar, F., & Xia, Y. (2018) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26973 · Cited by 18
Metadata
- Authors
- Bashir, A., Gray, M. L., & Burstein, D.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1996-11
- Volume
- 36
- Issue
- 5
- Pages
- 665-673
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1970857984
- Cited by
- 507
- References
- 10
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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